Since opening in 2009, Arraystar Inc. has successfully provided services for hundreds of esteemed universities, hospitals, and research centers, including NIH, FDA, UCSD, Rockefeller University, Columbia University, University of Toronto, M. D. Anderson Cancer Center and many others.
Arraystar LncRNA Array & Service
GUARDIN is a p53-responsive long non-coding RNA that is essential for genomic stability. Hu W L, et al. Nature Cell Biology, 2018
A novel lncRNA GClnc1 promotes gastric carcinogenesis and may act as a modular scaffold of WDR5 and KAT2A complexes to specify the histone modification pattern. Sun T T, et al. Cancer discovery, 2016
The LINK-A lncRNA interacts with PtdIns (3, 4, 5) P3 to hyperactivate AKT and confer resistance to AKT inhibitors. Lin A, et al. Nature Cell Biology, 2017
Integrative Transcriptome Analyses of Metabolic Responses in Mice Define Pivotal LncRNA Metabolic Regulators. Ling Yang, et al. Cell Metabolism, 2016
Wnt signalling modulates transcribed-ultraconserved regions in hepatobiliary cancers. Carotenuto P, et al. Gut, 2016
Differential transcriptome expression in human nucleus accumbens as a function of loneliness. Canli T, et al. Molecular Psychiatry, 2016
Long noncoding RNA Tug1 regulates mitochondrial bioenergetics in diabetic nephropathy. Long J, et al. The Journal of Clinical Investigation, 2016
The senescence-associated secretory phenotype is potentiated by feedforward regulatory mechanisms involving Zscan4 and TAK1. Zhang B, et al. Nature communications, 2018
Non-coding RNAs participate in the regulatory network of CLDN4 via ceRNA mediated miRNA evasion. Yong-xi Song,et al. Nature communications, 2017
Long Non-coding RNA DILC Represses Self-renewal of Liver Cancer Stem Cells via Inhibiting Autocrine IL-6/STAT3 Axis. X Wang, et al. Journal of Hepatology, 2016
Long non-coding RNA UICLM promotes colorectal cancer liver metastasis by acting as a ceRNA for microRNA-215 to regulate ZEB2 expression. Chen D, et al. Theranostics, 2017
Long noncoding RNA miR503HG, a prognostic indicator, inhibits tumor metastasis by regulating the HNRNPA2B1/NF-κB pathway in hepatocellular carcinoma. Wang H, et al. Theranostics, 2018
An acetyl-L-carnitine switch on mitochondrial dysfunction and rescue in the metabolomics study on aluminum oxide nanoparticles. Li X, et al. Particle and Fibre Toxicology, 2016
Taurine ameliorates particulate matter-induced emphysema by switching on mitochondrial NADH dehydrogenase genes. Li X, et al. Proceedings of the National Academy of Sciences, 2018
Angiogenic patterning by STEEL, an endothelial-enriched long noncoding RNA. Man H S J, et al. Proceedings of the National Academy of Sciences, 2018
Long non-coding RNA LINC00092 acts in cancer-associated fibroblasts to drive glycolysis and progression of ovarian cancer. Zhao L, et al. Cancer Research, 2017
Downregulation of Lnc-Spry1 mediates TGF-β-induced epithelial–mesenchymal transition by transcriptional and posttranscriptional regulatory mechanisms. Rodríguez-Mateo C, et al. Cell Death & Differentiation, 2017
Integrative Functional Transcriptomic Analyses Implicate Specific Molecular Pathways in pulmonary toxicity from Exposure to Aluminum Oxide Nanoparticles. Li X, et al. Nanotoxicology, 2016
Standardising RNA profiling based biomarker application in cancer-the need for robust control of technical variables. Stewart J P, et al. Biochimica et Biophysica Acta (BBA)-Reviews on Cancer, 2017
Tumor-derived exosomal lnc-Sox2ot promotes EMT and stemness by acting as a ceRNA in pancreatic ductal adenocarcinoma. Li Z, et al. Oncogene, 2018
KIF26B, a novel oncogene, promotes proliferation and metastasis by activating the VEGF pathway in gastric cancer. Zhang H, et al. Oncogene, 2017
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Arraystar circRNA Array & Service
A Circular RNA Protects Dormant Hematopoietic Stem Cells from DNA Sensor cGAS-Mediated Exhaustion. Xia P, et al. Immunity, 2018
Circular RNA MTO1 acts as the sponge of miR-9 to suppress hepatocellular carcinoma progression. Han D, et al. Hepatology (Baltimore, Md.), 2017
A Circular RNA Binds To and Activates AKT Phosphorylation and Nuclear Localization Reducing Apoptosis and Enhancing Cardiac Repair. Zeng Y, et al. Theranostics, 2017
circRNA Mediates Silica-Induced Macrophage Activation Via HECTD1/ZC3H12A-Dependent Ubiquitination. Zhou Z, et al. Theranostics, 2017
The circular RNA circPRKCI promotes tumor growth in lung adenocarcinoma. Qiu M, et al. Cancer Research, 2018
Enhanced breast cancer progression by mutant p53 is inhibited by the circular RNA circ-Ccnb1. Fang L,et al. Cell Death & Differentiation, 2018
circRNA_100290 plays a role in oral cancer by functioning as a sponge of the miR-29 family. Chen L, et al. Oncogene, 2017
CircIRAK3 sponges miR-3607 to facilitate breast cancer metastasis. Wu J, et al. Cancer Letters, 2018
Tumor-released exosomal circular RNA PDE8A promotes invasive growth via the miR-338/MACC1/MET pathway in pancreatic cancer. Li Z, et al. Cancer letters, 2018
Silencing circular RNA hsa_circ_0000977 suppresses pancreatic ductal adenocarcinoma progression by stimulating miR-874-3p and inhibiting PLK1 expression. Huang W J, et al. Cancer Letters, 2018
Circular RNA_LARP4 inhibits cell proliferation and invasion of gastric cancer by sponging miR-424-5p and regulating LATS1 expression. Zhang J, et al. Molecular Cancer, 2017
Circular RNA profiling reveals that circular RNAs from ANXA2 can be used as new biomarkers for multiple sclerosis. Iparraguirre L. et al. Human Molecular Genetics, 2017
Circular RNAs as novel regulators of β-cell functions in normal and disease conditions. Stoll L, et al. Molecular Metabolism, 2017
Changing expression profiles of lncRNAs, mRNAs, circRNAs and miRNAs during osteoclastogenesis. Dou C, et al. Scientific Reports, 2016
Circular RNA Related to the Chondrocyte ECM Regulates MMP13 Expression by Functioning as a MiR-136 'Sponge' in Human Cartilage Degradation. Liu Q, et al. Scientific Reports, 2016
circGFRA1 and GFRA1 act as ceRNAs in triple negative breast cancer by regulating miR-34a. He R,et al. Journal of Experimental & Clinical Cancer Research, 2017
Circ100284, via miR-217 regulation of EZH2, is involved in the arsenite-accelerated cell cycle of human keratinocytes in carcinogenesis. Xue J, et al. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 2017
RNA-binding Protein Trinucleotide repeat-containing 6A Regulates the Formation of Circular RNA 0006916, with Important Functions in Lung Cancer Cells. Dai X, et al. Carcinogenesis, 2018
CircRNA-0004904, CircRNA-0001855, and PAPP-A: Potential Novel Biomarkers for the Prediction of Preeclampsia. Jiang M, et al. Cellular Physiology and Biochemistry, 2018
Hsa_Circ_0001275: A Potential Novel Diagnostic Biomarker for Postmenopausal Osteoporosis. Zhao K, et al. Cellular Physiology and Biochemistry, 2018
Expression Profiling of Circular RNAs and Micrornas in Heart Tissue of Mice with Alcoholic Cardiomyopathy. Yang Y, et al. Cellular Physiology and Biochemistry, 2018
Microarray Expression Profile and Functional Analysis of Circular RNAs in Osteosarcoma. Liu W, et al. Cellular Physiology and Biochemistry, 2017
Microarray Expression Profile of Circular RNAs in Peripheral Blood Mononuclear Cells from Rheumatoid Arthritis Patients. Ouyang Q, et al. Cellular Physiology and Biochemistry, 2017
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Arraystar Gene Expression Array & Service
Osteoblast-secreted factors mediate dormancy of metastatic prostate cancer in the bone via activation of the TGFβRIII-p38MAPK-pS249/T252RB pathway. Yu-Lee L Y, et al. Cancer Research, 2018
MicroRNA-Mediated Dynamic Bidirectional Shift between the Subclasses of Glioblastoma Stem-like Cells. Rooj A K, et al. Cell Reports, 2017
MicroRNA Signatures and Molecular Subtypes of Glioblastoma: The Role of Extracellular Transfer. Godlewski J, et al. Stem Cell Reports, 2017
Bmal1 is required for beta cell compensatory expansion, survival and metabolic adaptation to diet-induced obesity in mice. Rakshit K, et al. Diabetologia, 2016
FOXP3 promotes tumor growth and metastasis by activating Wnt/β-catenin signaling pathway and EMT in non-small cell lung cancer. Yang S,et al. Molecular Cancer, 2017
Long noncoding RNA CRNDE stabilized by hnRNPUL2 accelerates cell proliferation and migration in colorectal carcinoma via activating Ras/MAPK signaling pathways. Jiang H, et al. Cell Death & Disease, 2017
In vitro expansion impaired the stemness of early passage mesenchymal stem cells for treatment of cartilage defects. Jiang T, et al. Cell Death & Disease, 2017
Circular RNAs as novel regulators of β-cell functions in normal and disease conditions. Stoll L, et al. Molecular Metabolism, 2017
PMP22 Regulates Self-Renewal and Chemoresistance of Gastric Cancer Cells. Cai W, et al. Molecular Cancer Therapeutics, 2017
Competing endogenous RNA expression profiling in pre-eclampsia identifies hsa_circ_0036877 as a potential novel blood biomarker for early pre-eclampsia. Hu X, et al. Clinical epigenetics, 2018
Differential Expression of MiR-106b-5p and MiR-200c-3p in Newly Diagnosed Versus Chronic Primary Immune Thrombocytopenia Patients Based on Systematic Analysis. Qian C, et al. Cellular Physiology and Biochemistry, 2018
miR-130a and miR-212 Disrupt the Intestinal Epithelial Barrier through Modulation of PPARγ and Occludin Expression in Chronic Simian Immunodeficiency Virus–Infected Rhesus Macaques. Kumar V, et al. The Journal of Immunology, 2018
ABCF2, an Nrf2 target gene, contributes to cisplatin resistance in ovarian cancer cells. L Bao, et al. Molecular Carcinogenesis, 2017
Differentially expressed host long intergenic noncoding RNA and mRNA in HIV-1 and HIV-2 infection. Biswas S, et al. Scientific Reports, 2018
miR-17-92 Cluster Promotes Cholangiocarcinoma Growth: Evidence for PTEN as Downstream Target and IL-6/Stat3 as Upstream Activator. H Zhu, et al. The American Journal of Pathology, 2014
Sucrose non-fermenting related kinase enzyme is essential for cardiac metabolism. Cossette SM, et al. Biol Open, 2014
Bifunctional enzyme SpoT is involved in the clarithromycin tolerance of Helicobacter pylori by up-regulating the transporters HP0939, HP1017, HP0497, and HP0471. Geng X,et al. Antimicrobial Agents and Chemotherapy, 2017
MeCP2, a target of miR-638, facilitates gastric cancer cell proliferation through activation of the MEK1/2-ERK1/2 signaling pathway by upregulating GIT1. Zhao L Y, et al. Oncogenesis, 2017
Chronic occupational exposure to arsenic induces carcinogenic gene signaling networks and neoplastic transformation in human lung epithelial cells. Todd A. Stueckle, et al. Toxicology and Applied Pharmacology, 2012
Arraystar piRNA Array & Service
PIWIL3/OIP5-AS1/miR-367-3p/CEBPA feedback loop regulates the biological behavior of glioma cells. Liu X, et al. Theranostics, 2018
RASSF1C modulation of Piwi-interacting RNAs (piRNAs) in lung cancer.YG Amaar, et al.Cancer Research, 2015
Roles of piRNAs in microcystin-leucine-arginine (MC-LR) induced reproductive toxicity in testis on male offspring. Zhang L, et al. Food and Chemical Toxicology, 2017
Piwi-interacting RNAs as novel prognostic markers in clear cell renal cell carcinomas. J Busch, et al. J Exp Clin Cancer Res, 2015
Altered Expression of PIWI RNA in the Rat Brain After Transient Focal Ischemia. Ashutosh Dharap, Venkata Prasuja Nakka and Raghu Vemuganti. STROKEAHA, 2010.
Arraystar LncPath™ Pathway Array Service
circRNA_100290 plays a role in oral cancer by functioning as a sponge of the miR-29 family. Chen L, et al. Oncogene, 2017
circRNA_0084043 promote malignant melanoma progression via miR-153-3p/Snail axis. Luan W, et al. Biochemical and biophysical research communications, 2018
Aberrantly expressed long noncoding RNAs are involved in sevoflurane-induced developing hippocampal neuronal apoptosis: a microarray related study.X Chen et al.Metabolic Brain Disease, 2016
Detection and Analysis of Wnt Pathway Related lncRNAs Expression Profile in Lung Adenocarcinoma. Chen J, et al. Pathology & Oncology Research, 2016
Decreased expression of long noncoding RNA MT1JP may be a novel diagnostic and predictive biomarker in gastric cancer. Yang J, et al. Int J Clin Exp Pathol, 2017
Expression of LOC285758, a potential long non-coding biomarker, is methylation-dependent and correlates with glioma malignancy grade. Matjasic A, et al. Radiology and Oncology, 2017
Arraystar T-UCR Array Service
Long Noncoding RNA uc.173 Promotes Renewal of the Intestinal Mucosa by Inducing Degradation of MicroRNA 195. Xiao L, et al. Gastroenterology, 2017
Noncoding Transcribed Ultraconserved Region (T-UCR) uc.261 Participates in Intestinal Mucosa Barrier Damage in Crohn's Disease. Qian X X, et al. inflammatory bowel diseases, 2016
Arraystar MeDIP-chip Service
MSC Transplantation Improves Osteopenia via Epigenetic Regulation of Notch Signaling in Lupus. Shiyu Liu, et al. Cell Metabolism, 2016
Long-term parental methamphetamine exposure of mice influences behavior and hippocampal DNA methylation of the offspring. Y Itzhak, et al. Molecular Psychiatry, 2014
TFIIS. h, a new target of p53, regulates transcription efficiency of pro-apoptotic bax gene. JM Liao, et al. Scientific Reports, 2016
Epigenetic inactivation of the CpG demethylase TET1 as a DNA methylation feedback loop in human cancers. Li L, et al. Scientific reports, 2016
Characterization of the nasopharyngeal carcinoma methylome identifies aberrant disruption of key signaling pathways and methylated tumor suppressor genes. Li L, et al. Epigenomics, 2014
Long lasting alterations to DNA methylation and ncRNAs may underlie the effects of fetal alcohol exposure. Benjamin I. Laufer, et al. Disease Models & Mechanisms, 2013
Sox9 transcriptionally regulates Wnt signaling in intestinal epithelial stem cells in hypomethylated crypts in the diabetic state. Huang C Z, et al. Stem Cell Research & Therapy, 2017
Increased 5‐hydroxymethylation levels in the hippocampus of rat extinguished from cocaine self‐administration. Sadakierska‐Chudy A, et al. Hippocampus, 2017
DNA methylation differences in monozygotic twin pairs discordant for schizophrenia identifies psychosis related genes and networks. Castellani CA, et al. BMC Med Genomics, 2015
Dietary Chromium Restriction of Pregnant Mice Changes the Methylation Status of Hepatic Genes Involved with Insulin Signaling in Adult Male Offspring. Zhang Q, et al. PLOS ONE, 2017
Olanzapine-induced methylation alters cadherin gene families and associated pathways implicated in psychosis. MG Melka, et al. BMC Neuroscience, 2014
Epigenetic modification of TLE1 induce abnormal differentiation in diabetic mice intestinal epithelium. Xu J,et al. Molecular and Cellular Biochemistry, 2017
Genome-Wide DNA Methylation in Mixed Ancestry Individuals with Diabetes and Prediabetes from South Africa. Matsha T E, et al. International Journal of Endocrinology, 2016
Olanzapine-induced DNA methylation in the hippocampus and cerebellum in genes mapped to human 22q11 and implicated in schizophrenia. MG Melka, et al. Psychiatric genetics, 2014
Arraystar hMeDIP-chip Service
TET3 Mediates Alterations in the Epigenetic Marker 5hmC and Akt Pathway in Steroid‐Associated Osteonecrosis. Zhao J, et al. Journal of Bone and Mineral Research, 2016
Arraystar RNA Sequencing Service
Patient-derived organoids model treatment response of metastatic gastrointestinal cancers. Vlachogiannis G, et al. Science, 2018
Genome-wide Identification of Long Noncoding RNAs in Rat Models of Cardiovascular and Renal Diseases. K Gopalakrishnan, et al. Hypertension, 2014
Arraystar microRNA Sequencing Service
Next-generation sequencing of the basal cell carcinoma miRNome and a description of novel microRNA candidates under neoadjuvant vismodegib therapy: an integrative molecular and surgical case study.Sand M, et al.Ann Oncol,2016
Molecular fingerprinting of the podocyte reveals novel gene and protein regulatory networks. Melanie Boerries, et al. Kidney International, 2013
Integrated analysis of dysregulated ncRNA and mRNA expression profiles in humans exposed to carbon nanotubes. Shvedova A A, et al. PloS one, 2016
Survival and Diversity of Human Homologous Dietary MicroRNAs in Conventionally Cooked Top Sirloin and Dried Bovine Tissue Extracts. Dever J T, et al. PloS one, 2015
Defining the rhesus macaque placental miRNAome: Conservation of expression of placental miRNA clusters between the macaque and human. Schmidt J K, et al. Placenta, 2018
MicroRNA Expression Varies according to Glucose Tolerance, Measurement Platform, and Biological Source. Dias S,et al. BioMed Research International, 2017
Arraystar ChIP-sequencing Service
The LINK-A lncRNA activates normoxic HIF1 [alpha] signalling in triple-negative breast cancer. Lin A,et al. Nature cell biology, 2016
Direct Transcriptional Effects of Apolipoprotein E. Veena Theendakara, et al. Neurobiology of Disease, 2016
Role for Dpy-30 in ES Cell-Fate Specification by Regulation of H3K4 Methylation within Bivalent Domains. Hao Jiang, et al. Cell, 2011
Arraystar MeDIP(hMeDIP)-sequencing Service
Loss of Endometrial Plasticity in Recurrent Pregnancy Loss Emma S. Lucas,et al. Stem cells, 2016.
Differential DNA methylation of microRNAs within promoters, intergenic and intragenic regions of type 2 diabetic, pre-diabetic and non-diabetic individuals. C Pheiffer,et al. Clinical Biochemistry, 2016.
Genome-wide DNA methylation in mixed ancestry individuals with diabetes and prediabetes from South Africa.TE Matsha, et al. 2016
Dynamic interplay between locus-specific DNA methylation and hydroxymethylation regulates distinct biological pathways in prostate carcinogenesis. Shivani N,et al. Clinical Epigenetics, 2015
Parp inhibition prevents ten eleven translocase enzyme activation and hyperglycemia induced DNA demethylation. Dhliwayo N, et al. Diabetes, 2014.
Characterization of the DNA methylome and its interindividual variation in human peripheral blood monocytes. Hui Shen, et al. Epigenomics, 2013.
Heritable Transmission of Diabetic Metabolic Memory in Zebrafish Correlates With DNA Hypomethylation and Aberrant Gene Expression. Ansgar S. Olsen, et al. Diabetes, 2012.
Arraystar CLIP-sequencing Service
Intronic RNAs mediate EZH2 regulation of epigenetic targets. Sonia Guil, et al. Nature Structural & Molecular Biology, 2012
Real-Time qPCR Reagents and Kits
miR-21 silencing ameliorates experimental autoimmune encephalomyelitis by promoting the differentiation of IL-10-producing B cells. Wang H, et al. Oncotarget, 2017
Long noncoding RNA HAS2‐AS1 mediates hypoxia‐induced invasiveness of oral squamous cell carcinoma. Zhu G, et al. Molecular Carcinogenesis, 2017
Mir-344b-1-3p targets Tlr2 and negatively regulates Tlr2 signaling pathway. Wu Y, et al. International Journal of COPD, 2017
Scutellarin suppresses human colorectal cancer metastasis and angiogenesis by targeting ephrinb2. Zhu P T, et al. Am J Transl Res, 2017
Plasma lncRNA GAS8-AS1 as a Potential Biomarker of Papillary Thyroid Carcinoma in Chinese Patients. Zhang D,et al. International Journal of Endocrinology, 2017
Anxiety-like behavior and dysregulation of miR-34a in triple transgenic mice of Alzheimer’s disease. Y.-L. Zhang, et al. Eur Rev Med Pharmacol Sci , 2016
Physiological and transcriptional responses of Nitrosomonas europaea to TiO2 and ZnO nanoparticles and their mixtures. Yu R, Wu J, Liu M, et al. Environmental Science and Pollution Research, 2016
Seq-Star™ NGS Solutions
circRNA_100290 plays a role in oral cancer by functioning as a sponge of the miR-29 family. Chen L, et al. Oncogene, 2017
Systematic identification and comparison of expressed profiles of lncRNAs and circRNAs with associated co-expression and ceRNA networks in mouse germline stem cells. Li X, Ao J, Wu J. Oncotarget, 2017
Integrative analysis for the role of long non-coding RNAs in radiation-induced mouse thymocytes responses. Hui Gao, et al. Acta Biochimica et Biophysica Sinica, 2016
LC-MS
Elongator and codon bias regulate protein levels in mammalian peripheral neurons. Goffena J, et al. Nature Communications, 2018
nrStar™ Functional LncRNA PCR Array
LncRNA ZEB2-AS1 promotes pancreatic cancer cell growth and invasion through regulating the miR-204/HMGB1 axis. Gao H, et al. International journal of biological macromolecules, 2018