Since opening in 2009, Arraystar Inc. has successfully provided services for hundreds of esteemed universities, hospitals, and research centers, including NIH, FDA, UCSD, Rockefeller University, Columbia University, University of Toronto, M. D. Anderson Cancer Center and many others.

Arraystar LncRNA Array & Service
GUARDIN is a p53-responsive long non-coding RNA that is essential for genomic stability. Hu W L, et al. Nature Cell Biology, 2018

A novel lncRNA GClnc1 promotes gastric carcinogenesis and may act as a modular scaffold of WDR5 and KAT2A complexes to specify the histone modification pattern. Sun T T, et al. Cancer discovery, 2016

The LINK-A lncRNA interacts with PtdIns (3, 4, 5) P3 to hyperactivate AKT and confer resistance to AKT inhibitors. Lin A, et al. Nature Cell Biology, 2017

Integrative Transcriptome Analyses of Metabolic Responses in Mice Define Pivotal LncRNA Metabolic Regulators. Ling Yang, et al. Cell Metabolism, 2016

Wnt signalling modulates transcribed-ultraconserved regions in hepatobiliary cancers. Carotenuto P,  et al. Gut, 2016

Differential transcriptome expression in human nucleus accumbens as a function of loneliness. Canli T, et al. Molecular Psychiatry, 2016

Long noncoding RNA Tug1 regulates mitochondrial bioenergetics in diabetic nephropathy. Long J,  et al. The Journal of Clinical Investigation, 2016

The senescence-associated secretory phenotype is potentiated by feedforward regulatory mechanisms involving Zscan4 and TAK1. Zhang B,  et al. Nature communications, 2018

Non-coding RNAs participate in the regulatory network of CLDN4 via ceRNA mediated miRNA evasion. Yong-xi Song,et al. Nature communications, 2017

Long Non-coding RNA DILC Represses Self-renewal of Liver Cancer Stem Cells via Inhibiting Autocrine IL-6/STAT3 Axis. X Wang, et al. Journal of Hepatology, 2016

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Arraystar circRNA Array & Service
A Circular RNA Protects Dormant Hematopoietic Stem Cells from DNA Sensor cGAS-Mediated Exhaustion. Xia P, et al. Immunity, 2018

Circular RNA MTO1 acts as the sponge of miR-9 to suppress hepatocellular carcinoma progression. Han D, et al. Hepatology (Baltimore, Md.), 2017 

circEPSTI1 as a prognostic marker and mediator of triple-negative breast cancer progression. Chen B, et al. Theranostics, 2018

A Circular RNA Binds To and Activates AKT Phosphorylation and Nuclear Localization Reducing Apoptosis and Enhancing Cardiac Repair. Zeng Y, et al. Theranostics, 2017

circRNA Mediates Silica-Induced Macrophage Activation Via HECTD1/ZC3H12A-Dependent Ubiquitination. Zhou Z, et al. Theranostics, 2017

The circular RNA circPRKCI promotes tumor growth in lung adenocarcinoma. Qiu M, et al. Cancer Research, 2018

Enhanced breast cancer progression by mutant p53 is inhibited by the circular RNA circ-Ccnb1. Fang L,et al. Cell Death & Differentiation, 2018

circRNA_100290 plays a role in oral cancer by functioning as a sponge of the miR-29 family. Chen L, et al. Oncogene, 2017

CircIRAK3 sponges miR-3607 to facilitate breast cancer metastasis. Wu J, et al. Cancer Letters, 2018

Tumor-released exosomal circular RNA PDE8A promotes invasive growth via the miR-338/MACC1/MET pathway in pancreatic cancer. Li Z, et al. Cancer letters, 2018

Silencing circular RNA hsa_circ_0000977 suppresses pancreatic ductal adenocarcinoma progression by stimulating miR-874-3p and inhibiting PLK1 expression. Huang W J, et al. Cancer Letters, 2018   

Circular RNA_LARP4 inhibits cell proliferation and invasion of gastric cancer by sponging miR-424-5p and regulating LATS1 expression. Zhang J, et al. Molecular Cancer, 2017   

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nrStar™ Functional LncRNA PCR Array
LncRNA ZEB2-AS1 promotes pancreatic cancer cell growth and invasion through regulating the miR-204/HMGB1 axis. Gao H, et al. International journal of biological macromolecules, 2018

 

NuRNA™ mRNA PCR Array
CPT1A-mediated fatty acid oxidation promotes colorectal cancer cell metastasis by inhibiting anoikis. Wang Y, et al. Oncogene, 2018 (NuRNA™ Human Central Metabolism PCR Array)

 

Arraystar Gene Expression Array & Service
Osteoblast-secreted factors mediate dormancy of metastatic prostate cancer in the bone via activation of the TGFβRIII-p38MAPK-pS249/T252RB pathway. Yu-Lee L Y, et al. Cancer Research, 2018

MicroRNA-Mediated Dynamic Bidirectional Shift between the Subclasses of Glioblastoma Stem-like Cells. Rooj A K, et al. Cell Reports, 2017

MicroRNA Signatures and Molecular Subtypes of Glioblastoma: The Role of Extracellular Transfer. Godlewski J,  et al. Stem Cell Reports, 2017

Bmal1 is required for beta cell compensatory expansion, survival and metabolic adaptation to diet-induced obesity in mice. Rakshit K, et al. Diabetologia, 2016

Circular RNAs as novel regulators of β-cell functions in normal and disease conditions. Stoll L, et al. Molecular Metabolism, 2017

miR-130a and miR-212 Disrupt the Intestinal Epithelial Barrier through Modulation of PPARγ and Occludin Expression in Chronic Simian Immunodeficiency Virus–Infected Rhesus Macaques. Kumar V, et al. The Journal of Immunology, 2018

Differentially expressed host long intergenic noncoding RNA and mRNA in HIV-1 and HIV-2 infection. Biswas S, et al. Scientific Reports, 2018

Silencing of CD40 in vivo reduces progression of experimental atherogenesis through an NF-κB/miR-125b axis and reveals new potential mediators in the pathogenesis of atherosclerosis. Hueso M, et al. Atherosclerosis​, 2016

Common gene-network signature of different neurological disorders and their potential implications to neuroAIDS. Sagar V, et al.  PloS one, 2017

Pleiotropic Effect of a High Resolution Mapped Blood Pressure QTL on Tumorigenesis. Cheng X, et al. PloS one, 2016

Genetic predisposition to high anxiety-and depression-like behavior coincides with diminished DNA methylation in the adult rat amygdala. McCoy C R,  et al. Behavioural Brain Research​, 2016

Identification of gene signatures regulated by carvedilol in mouse heart. Jian-peng Teoh, et al. Physiol Genomics, 2016 

SPARC overexpression suppresses radiation-induced HSP27 and induces the collapse of mitochondrial Δψ in neuroblastoma cells. Tanpure S,  et al. Oncology Letters, 2017

Sucrose non-fermenting related kinase enzyme is essential for cardiac metabolism. Cossette SM, et al. Biol Open, 2014

Chronic occupational exposure to arsenic induces carcinogenic gene signaling networks and neoplastic transformation in human lung epithelial cells. Todd A. Stueckle, et al. Toxicology and Applied Pharmacology, 2012

Arraystar piRNA Array & Service
PIWIL3/OIP5-AS1/miR-367-3p/CEBPA feedback loop regulates the biological behavior of glioma cells. Liu X,  et al. Theranostics, 2018

RASSF1C modulation of Piwi-interacting RNAs (piRNAs) in lung cancer.YG Amaar, et al.Cancer Research, 2015

Roles of piRNAs in microcystin-leucine-arginine (MC-LR) induced reproductive toxicity in testis on male offspring. Zhang L, et al. Food and Chemical Toxicology, 2017    

Piwi-interacting RNAs as novel prognostic markers in clear cell renal cell carcinomas. J Busch, et al. J Exp Clin Cancer Res, 2015

Altered Expression of PIWI RNA in the Rat Brain After Transient Focal Ischemia. Ashutosh Dharap, Venkata Prasuja Nakka and Raghu Vemuganti. STROKEAHA, 2010.

Arraystar LncPath™ Pathway Array Service
circRNA_100290 plays a role in oral cancer by functioning as a sponge of the miR-29 family. Chen L, et al. Oncogene, 2017

Identification and functional annotation of metabolism‐associated lnc RNA s and their related protein‐coding genes in gastric cancer. Mo X, et al. Molecular genetics & genomic medicine, 2018

circRNA_0084043 promote malignant melanoma progression via miR-153-3p/Snail axis. Luan W, et al. Biochemical and biophysical research communications, 2018
 
Aberrantly expressed long noncoding RNAs are involved in sevoflurane-induced developing hippocampal neuronal apoptosis: a microarray related study.X Chen et al.Metabolic Brain Disease, 2016

Detection and Analysis of Wnt Pathway Related lncRNAs Expression Profile in Lung Adenocarcinoma. Chen J, et al. Pathology & Oncology Research, 2016

Decreased expression of long noncoding RNA MT1JP may be a novel diagnostic and predictive biomarker in gastric cancer. Yang J, et al. Int J Clin Exp Pathol, 2017

Expression of LOC285758, a potential long non-coding biomarker, is methylation-dependent and correlates with glioma malignancy grade. Matjasic A, et al. Radiology and Oncology, 2017

Arraystar T-UCR Array Service
Long Noncoding RNA uc.173 Promotes Renewal of the Intestinal Mucosa by Inducing Degradation of MicroRNA 195. Xiao L, et al. Gastroenterology, 2017

Noncoding Transcribed Ultraconserved Region (T-UCR) uc.261 Participates in Intestinal Mucosa Barrier Damage in Crohn's Disease. Qian X X, et al. inflammatory bowel diseases, 2016

Arraystar MeDIP-chip Service
MSC Transplantation Improves Osteopenia via Epigenetic Regulation of Notch Signaling in Lupus. Shiyu Liu, et al. Cell Metabolism, 2016

Long-term parental methamphetamine exposure of mice influences behavior and hippocampal DNA methylation of the offspring. Y Itzhak, et al. Molecular Psychiatry, 2014

TFIIS. h, a new target of p53, regulates transcription efficiency of pro-apoptotic bax gene. JM Liao, et al. Scientific Reports, 2016

Epigenetic inactivation of the CpG demethylase TET1 as a DNA methylation feedback loop in human cancers. Li L, et al. Scientific reports, 2016

Characterization of the nasopharyngeal carcinoma methylome identifies aberrant disruption of key signaling pathways and methylated tumor suppressor genes. Li L, et al. Epigenomics, 2014

Long lasting alterations to DNA methylation and ncRNAs may underlie the effects of fetal alcohol exposure. Benjamin I. Laufer, et al. Disease Models & Mechanisms, 2013

Sox9 transcriptionally regulates Wnt signaling in intestinal epithelial stem cells in hypomethylated crypts in the diabetic state. Huang C Z, et al. Stem Cell Research & Therapy, 2017

Increased 5‐hydroxymethylation levels in the hippocampus of rat extinguished from cocaine self‐administration. Sadakierska‐Chudy A,  et al. Hippocampus, 2017

DNA methylation differences in monozygotic twin pairs discordant for schizophrenia identifies psychosis related genes and networks. Castellani CA, et al. BMC Med Genomics, 2015

Dietary Chromium Restriction of Pregnant Mice Changes the Methylation Status of Hepatic Genes Involved with Insulin Signaling in Adult Male Offspring. Zhang Q,  et al. PLOS ONE, 2017

Olanzapine-induced methylation alters cadherin gene families and associated pathways implicated in psychosis. MG Melka, et al. BMC Neuroscience, 2014

Epigenetic modification of TLE1 induce abnormal differentiation in diabetic mice intestinal epithelium. Xu J,et al. Molecular and Cellular Biochemistry, 2017

Genome-Wide DNA Methylation in Mixed Ancestry Individuals with Diabetes and Prediabetes from South Africa. Matsha T E, et al. International Journal of Endocrinology, 2016

Olanzapine-induced DNA methylation in the hippocampus and cerebellum in genes mapped to human 22q11 and implicated in schizophrenia. MG Melka, et al. Psychiatric genetics, 2014

Arraystar hMeDIP-chip Service
TET3 Mediates Alterations in the Epigenetic Marker 5hmC and Akt Pathway in Steroid‐Associated Osteonecrosis. Zhao J, et al. Journal of Bone and Mineral Research, 2016

Arraystar RNA Sequencing Service
Patient-derived organoids model treatment response of metastatic gastrointestinal cancers. Vlachogiannis G, et al. Science, 2018

Genome-wide Identification of Long Noncoding RNAs in Rat Models of Cardiovascular and Renal Diseases. K Gopalakrishnan, et al. Hypertension, 2014

Arraystar microRNA Sequencing Service 
Defining the rhesus macaque placental miRNAome: Conservation of expression of placental miRNA clusters between the macaque and human. Schmidt J K, et al. Placenta, 2018

Integrated analysis of microRNA and transcription factor reveals important regulators and regulatory motifs in adult B-cell acute lymphoblastic leukemia. Shvedova A A, et al. International Journal of Oncology, 2017

​MicroRNA Expression Varies according to Glucose Tolerance, Measurement Platform, and Biological Source. Dias S,et al. BioMed Research International, 2017

Next-generation sequencing of the basal cell carcinoma miRNome and a description of novel microRNA candidates under neoadjuvant vismo***** therapy: an integrative molecular and surgical case study.Sand M, et al.Ann Oncol,2016

Integrated analysis of dysregulated ncRNA and mRNA expression profiles in humans exposed to carbon nanotubes. Shvedova A A, et al. PloS one, 2016

Survival and Diversity of Human Homologous Dietary MicroRNAs in Conventionally Cooked Top Sirloin and Dried Bovine Tissue Extracts. Dever J T, et al. PloS one, 2015

Molecular fingerprinting of the podocyte reveals novel gene and protein regulatory networks. Melanie Boerries, et al. Kidney International, 2013

 

Arraystar ChIP-sequencing Service
The LINK-A lncRNA activates normoxic HIF1 [alpha] signalling in triple-negative breast cancer. Lin A,et al. Nature cell biology, 2016

Direct Transcriptional Effects of Apolipoprotein E. Veena Theendakara, et al. Neurobiology of Disease, 2016

Role for Dpy-30 in ES Cell-Fate Specification by Regulation of H3K4 Methylation within Bivalent Domains. Hao Jiang, et al. Cell, 2011

Arraystar (h)MeDIP-sequencing Service
Loss of Endometrial Plasticity in Recurrent Pregnancy Loss Emma S. Lucas,et al. Stem cells, 2016.

Differential DNA methylation of microRNAs within promoters, intergenic and intragenic regions of type 2 diabetic, pre-diabetic and non-diabetic individuals. C Pheiffer,et al. Clinical Biochemistry, 2016.

Genome-wide DNA methylation in mixed ancestry individuals with diabetes and prediabetes from South Africa.TE Matsha, et al. International Journal of Endocrinology​, 2016

Dynamic interplay between locus-specific DNA methylation and hydroxymethylation regulates distinct biological pathways in prostate carcinogenesis. Shivani N,et al. Clinical Epigenetics, 2015

Parp inhibition prevents ten eleven translocase enzyme activation and hyperglycemia induced DNA demethylation. Dhliwayo N, et al. Diabetes, 2014.

Characterization of the DNA methylome and its interindividual variation in human peripheral blood monocytes. Hui Shen, et al. Epigenomics, 2013.

Heritable Transmission of Diabetic Metabolic Memory in Zebrafish Correlates With DNA Hypomethylation and Aberrant Gene Expression. Ansgar S. Olsen, et al. Diabetes, 2012.

Arraystar CLIP-sequencing Service
Intronic RNAs mediate EZH2 regulation of epigenetic targets. Sonia Guil, et al. Nature Structural & Molecular Biology, 2012

Real-Time qPCR Reagents and Kits
miR-21 silencing ameliorates experimental autoimmune encephalomyelitis by promoting the differentiation of IL-10-producing B cells. Wang H, et al. Oncotarget, 2017

Long noncoding RNA HAS2‐AS1 mediates hypoxia‐induced invasiveness of oral squamous cell carcinoma. Zhu G, et al. Molecular Carcinogenesis, 2017  

Mir-344b-1-3p targets Tlr2 and negatively regulates Tlr2 signaling pathway. Wu Y,  et al. International Journal of COPD, 2017

Scutellarin suppresses human colorectal cancer metastasis and angiogenesis by targeting ephrinb2. Zhu P T, et al. Am J Transl Res, 2017

Plasma lncRNA GAS8-AS1 as a Potential Biomarker of Papillary Thyroid Carcinoma in Chinese Patients. Zhang D,et al. International Journal of Endocrinology, 2017  

NADPH oxidase inhibitor improves outcome of mechanical reperfusion by suppressing hemorrhagic transformation. Tuo Y H, et al. Journal of neurointerventional surgery, 2017

NADPH oxidase inhibitor regulates microRNAs with improved outcome after mechanical reperfusion. Liu Z, Tuo Y H, et al. Journal of neurointerventional surgery, 2016

Anxiety-like behavior and dysregulation of miR-34a in triple transgenic mice of Alzheimer’s disease​. Y.-L. Zhang, et al. Eur Rev Med Pharmacol Sci ​, 2016

Physiological and transcriptional responses of Nitrosomonas europaea to TiO2 and ZnO nanoparticles and their mixtures. Yu R, Wu J, Liu M, et al. Environmental Science and Pollution Research, 2016  

Seq-Star™ NGS Solutions
circRNA_100290 plays a role in oral cancer by functioning as a sponge of the miR-29 family. Chen L, et al. Oncogene, 2017 

Systematic identification and comparison of expressed profiles of lncRNAs and circRNAs with associated co-expression and ceRNA networks in mouse germline stem cells. Li X, Ao J, Wu J. Oncotarget, 2017 

Integrative analysis for the role of long non-coding RNAs in radiation-induced mouse thymocytes responses. Hui Gao, et al. Acta Biochimica et Biophysica Sinica, 2016

LC-MS
Elongator and codon bias regulate protein levels in mammalian peripheral neurons. Goffena J, et al. Nature Communications, 2018