rtStar™ tRNA Pretreatment & First-Strand cDNA Synthesis Kit is designed for reverse transcribing tRNAs efficiently.
• Efficient removal of internal modifications of tRNAs to ensure the proceeding of reverse transcriptase during cDNA synthesis, whereas the regular cDNA synthesis method doesn’t have.
• Magnitudes of increase in tRNA detection sensitivity and quantification accuracy with the treated compared with untreated samples.
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rtStar™ tRNA Pretreatment & First-Strand cDNA Synthesis Kit
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Gene-Specific Control of tRNA Expression by RNA Polymerase II. Gerber A, et al. Molecular Cell, 2020
Quantitative tRNA-sequencing uncovers metazoan tissue-specific tRNA regulation. Pinkard O, et al. Nature Communications, 2020
tRNA-based prognostic score in predicting survival outcomes of lung adenocarcinomas. Kuang M, et al. International journal of cancer, 2019
DNA damage-induced cell death relies on SLFN11-dependent cleavage of distinct type II tRNAs. Li M, et al. Nature Structural & Molecular Biology, 2018