• Description
  • Highlights
  • Human Database
  • Mouse Database
Product NameCatalog NoDescriptionFormatPrice
LncPath™ Mouse EMT Pathway Microarray AS-LP-004M 386 LncRNAs and 357 potential coding targets 8*15K
LncPath™ Human EMT Pathway Microarray AS-LP-004H 773 LncRNAs and 219 potential coding targets 8*15K

Epithelial-Mesenchymal Transition [1] is the process by which epithelial cells lose cell-cell junctions and baso-apical polarity while acquire plasticity, mobility, invasive capacity, stem-like characteristics, and apoptosis resistance. The cellular program is normally active in embryogenesis and wound healing. Pathologically EMT is also active in cancer metastasis which provides critical impetus for epithelial malignancies to acquire metastatic capability [2]. Recent research has suggested that LncRNAs might be key regulators of EMT process, adding an important new layer to our understanding of tumor cell plasticity and the regulation of EMT pathway in cancers.

The LncPath™ Human EMT Pathway LncRNA Microarray simultaneously profiles the expression of 773 LncRNAs and 219 their potential coding targets related to EMT signaling pathway. The LncPath™ Mouse EMT Pathway LncRNA Microarray simultaneously profiles the expression of 386 LncRNAs and 357 their potential coding targets related to EMT signaling pathway. All the LncRNAs that have already been proven to be associated with the EMT pathway are manually curated from literature. Furthermore, the LncRNAs whose gene loci located at or near the protein-coding genes critical in EMT pathway, and the LncRNAs which have high possibility as the potential ceRNAs of the key EMT-associated genes, are also carefully selected from the authoritative databases by using a rigorous process. By limiting LncRNAs to those most relevant to EMT pathway, analysis can be achieved quickly and precisely due to a highly specific yet smaller data set. The expressional relationship between the EMT-associated LncRNAs and their potential protein-coding targets can be established to gain comprehensive insights into the underlying regulatory mechanisms of LncRNAs in EMT process.

Reliable EMT pathway focus LncRNA collection
Simultaneous analysis of LncRNAs and their potential coding gene targets related to the EMT pathway
Efficient and robust labeling system
Innovative probe design
Guaranteed performance

An example showing the detailed information about the LncRNAs and their potential coding gene target

Click the LncRNA accession number listed in databases, you will see the figures showing the detailed information about the LncRNAs and their potential target gene.


Figure 1. The genomic map views of , the LncRNA ENST00000557223 and its potential target gene AKT1. From the top to the bottom of the figure 1, the following items are displayed:

Genome view: A chromosome ideogram showing the map position of the LncRNA ENST00000557223 and its potential target gene AKT1 (red bar).
Map view ruler: The map coordinates of the human genome assembly hg19 for the map views below.
LncRNA map view: The LncRNAs whose genes located at or near the AKT1 gene are presented in the Noncoding panel (shaded green). The LncRNAs are indicated by the transcript IDs, the exons by solid blocks, the introns by thin lines, and the transcription directions by arrows. The exons of LncRNA ENST00000557223 are labeled in red, while the exons of the other LncRNAs are labeled in blue.
Coding gene map view: The coding gene AKT1 is presented in the Coding panel (shaded blue). The coding gene is indicated by its canonical transcript ID, the exons by solid blocks, the introns by thin lines, and the transcription direction by arrows.


Figure 2. The relationship between LncRNA ENST00000557223 and its protein coding gene target AKT1. The other neighboring LncRNAs which may regulate AKT1 expression are also shown.


Figure 3. The LncRNA uc010mzx.1 may function as a competing endogenous RNA (ceRNA) of the protein coding gene AKT1.
* MuTaMe Score, Mutually Targeted MRE Enrichment Score [3].

References1.   Nordentoft, I., et al., miRNAs associated with chemo-sensitivity in cell lines and in advanced bladder cancer. BMC Med Genomics, 2012. 5(1): p. 40.
2.   Talbot, L.J., S.D. Bhattacharya, and P.C. Kuo, Epithelial-mesenchymal transition, the tumor microenvironment, and metastatic behavior of epithelial malignancies. Int J Biochem Mol Biol, 2012. 3(2): p. 117-36.
3.  Tay, Y., et al., Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs. Cell, 2011. 147(2): p. 344-57.

LncRNA List
The human EMT pathway LncRNAs are listed in Table 1. Click the LncRNA accession numbers to see the detailed information about the LncRNAs and their potential coding gene targets in the EMT pathway.

Table 1. Human EMT pathway focused LncRNAs

ENST00000369391, ENST00000379816, ENST00000380601, ENST00000381361, ENST00000411715, ENST00000412951, ENST00000412972, ENST00000413598, ENST00000414314, ENST00000415054, ENST00000416061, ENST00000416080, ENST00000416554, ENST00000417460, ENST00000417539, ENST00000419491, ENST00000419906, ENST00000419944, ENST00000419973, ENST00000420537, ENST00000421083, ENST00000422040, ENST00000422510, ENST00000423102, ENST00000423212, ENST00000423367, ENST00000423714, ENST00000424191, ENST00000424409, ENST00000426580, ENST00000426860, ENST00000427278, ENST00000427409, ENST00000429224, ENST00000432033, ENST00000434541, ENST00000434689, ENST00000434984, ENST00000435478, ENST00000436097, ENST00000436876, ENST00000436882, ENST00000437232, ENST00000439501, ENST00000440589, ENST00000441212, ENST00000442417, ENST00000443034, ENST00000443800, ENST00000445956, 

Full List of Human EMT Pathway Focused LncRNAs.pdf

Gene List
The potential gene targets of the human EMT pathway focus LncRNAs are listed in Table 2. Click the protein gene names to see the detailed information about the genes and their corresponding regulatory LncRNAs in the EMT pathway.

Table 2. Functional gene grouping

Receptor Tyrosine Kinase:
EGFR ERBB3 PDGFRB RGS2 SPARC
Proliferation:
CDK4 CCND1 CCND2 CCNG2 CDKN2A CDKN1A CDKN1B PCNA
Alternative Splicing Regulators of EMT:
CEBPD ESRP1 ESRP2 MBNL1 PTBP1 RBFOX2
Motility and invasion:
ACAN MMP13 MMP2 MMP3 MMP9 SPP1 RHOB CXCL12 SPARC VDR
EMT Inducers:
BMP1 BMP2 BMP3 BMP4 BMP5 BMP6 BMP7 EGF MMP28 FGF1 FGF2 HGF IGF1 IGF2 IL6 FAM3C JAG1 LAMB3 MMP13 MMP3 NRG1 NRG2 NRG3 NRG4 NOTCH1 NOTCH2 NOTCH3 NOTCH4 SPP1 FIGF PDGFA PDGFB PDGFC PDGFD VEGFB VEGFC POSTN SHH TGFB1 TGFB2 TGFB3 TMPRSS4 VEGFA VTN WNT1 WNT10A WNT2 WNT2B WNT3 WNT3A WNT4 WNT6 WNT7A WNT7B WNT8A
EMT-inducing Transcriptional Factors (EMT-TFs):
T ELSPBP1 TCF4 TCF3 ETS1 FOXC2 GSC KLF8 LEF1 SNAI1 SNAI2 TWIST1 ZEB1 ZEB2
WNT:
CTNNB1 FZD7 GSK3B WNT11 WNT5A WNT5B
Epigenetic Regulators of EMT:
BMI1 RNF20 SMARCA4 SMARCA2 OPN1LW DOT1L EZH2 EHMT2 HDAC1 HDAC2 HDAC3 HDAC4 HDAC6 KDM3A KDM4B KDM4C LOXL2 KDM1A MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 NAP1L1 EP300 PKM RUVBL1 PRMT2 RUVBL2 SETD8 SIRT1 SUV39H1 SUZ12 TRIM33 WDR5
Posttranslational regulation for E-cadherin:
ARF6 MET NME1 SMAP1 SRC
Posttranslational regulation for EMT-TFs:
RASGRP1 CSNK1A1 CSN2 FBXL14 PCBP1 LATS2 SLC39A6 MDM2 PAK1 PRKD1 YBX1
Epithelial Markers:
DSP JUP CDH1 LAMA1 MUC1 TJP1
Targets subject to EMT-associated alternative splicing:
ARHGAP17 ARHGEF11 BAIAP2 CD44 CTNND1 DNM2 ENAH EPB41L5 FGFR2 FLNB ITGA6 LRRFIP2 MAGI1 MAP3K7 NUMB RALGPS2 MST1R SCRIB SLK TCF7L2
Estrogen Receptor:
CAV2 ESR1 KRT19 TGFB3
Translational Regulators of EMT:
PCBP1 YBX1
G-Protein Coupled Receptor:
AKT1 FZD7 GNG11 RAC1 RGS2
Notch:
FOXC2 JAG1 NOTCH1
TGF/BMP:
BMP1 BMP2 BMP7 COL3A1 SMAD2 TGFB1 TGFB2 TGFB3
Survival:
ATM BCL2L1 BID CXCL1 DFFB FOS FOXG1 MST4 MT1A MT1B MT1E MT1F MT1G MT1H MT1M MT1X TP53 TP73 BBC3
Mesenchymal Markers:
DDR2 FN1 S100A4 LAMA3 CDH12 CDH2 CDH11 SDC1 VIM CTNNB1
Integrin-Mediated:
COL3A1 ILK ITGA5 ITGAV ITGB1 PTK2

LncRNA List
The mouse EMT pathway LncRNAs are listed in Table 1. Click the LncRNA accession numbers to see the detailed information about the LncRNAs and their potential coding gene targets in the EMT pathway.

Table 1. Mouse EMT pathway focused LncRNAs

Hipk2, Rere, Nrg4, Dnajb4, Fgf2, Xpc, Mob1b, Rad18, Atrip, Adrbk1, Chd7, Ets1

Full List of Mouse EMT Pathway Focused LncRNAs.pdf

 Gene List
The potential gene targets of the mouse EMT pathway focus LncRNAs are listed in Table 2. Click the protein gene names to see the detailed information about the genes and their corresponding regulatory LncRNAs in the EMT pathway.

Table 2. Functional gene grouping

Receptor Tyrosine Kinase:
Egfr Erbb3 Pdgfrb Rgs2 Sparc
Proliferation:
Cdk4 Ccnd1 Ccnd2 Ccng2 Cdkn2a Cdkn1a Cdkn1b Pcna
Alternative Splicing Regulators of EMT:
Cebpd Esrp1 Esrp2 Mbnl1 Ptbp1 Rbfox2
Motility and invasion:
Acan Mmp13 Mmp2 Mmp3 Mmp9 Spp1 Rhob Sparc Vdr
EMT Inducers:
Bmp1 Bmp2 Bmp3 Bmp4 Bmp5 Bmp6 Bmp7 Egf Mmp28 Fgf1 Fgf2 Hgf Igf1 Igf2 Il6 Fam3c Jag1 Lamb3 Mmp13 Mmp3 Nrg2 Nrg3 Nrg4 Notch1 Notch2 Notch3 Notch4 Spp1 Figf Pdgfa Pdgfb Pdgfc Pdgfd Vegfc Postn Shh Tgfb1 Tgfb2 Tgfb3 Tmprss4 Vegfa Vtn Wnt1 Wnt10a Wnt2 Wnt2b Wnt3 Wnt3a Wnt4 Wnt6 Wnt7a Wnt7b Wnt8a
EMT-inducing Transcriptional Factors (EMT-TFs):
T Tcf4 Tcf3 Ets1 Foxc2 Gsc Klf8 Lef1 Snai1 Snai2 Twist1 Zeb1 Zeb2
WNT:
Ctnnb1 Fzd7 Gsk3b Wnt11 Wnt5a Wnt5b
Epigenetic Regulators of EMT:
Rnf20 Smarca4 Smarca2 Opn1mw Dot1l Ezh2 Ehmt2 Hdac1 Hdac2 Hdac3 Hdac4 Hdac6 Kdm3a Kdm4b Kdm4c Loxl2 Kdm1a Mcm2 Mcm3 Mcm4 Mcm5 Mcm6 Mcm7 Nap1l1 Ep300 Pkm Ruvbl1 Prmt2 Ruvbl2 Setd8 Sirt1 Suv39h1 Suz12 Trim33 Wdr5
Posttranslational regulation for E-cadherin:
Arf6 Met Nme1 Smap1 Src
Posttranslational regulation for EMT-TFs:
Rasgrp1 Csnk1a1 Csn2 Fbxl14 Pcbp1 Lats2 Slc39a6 Mdm2 Pak1 Prkd1 Ybx1
Epithelial Markers:
Dsp Jup Cdh1 Lama1 Muc1 Tjp1
Targets subject to EMT-associated alternative splicing:
Arhgap17 Arhgef11 Baiap2 Cd44 Ctnnd1 Dnm2 Epb4.1l5 Fgfr2 Flnb Itga6 Magi1 Map3k7 Numb Ralgps2 Mst1r Scrib Slk Tcf7l2
Estrogen Receptor:
Cav2 Esr1 Krt19 Tgfb3
Translational Regulators of EMT:
Pcbp1 Ybx1
G-Protein Coupled Receptor:
Akt1 Fzd7 Gng11 Rac1 Rgs2
Notch:
Foxc2 Jag1 Notch1
TGF/BMP:
Bmp1 Bmp2 Bmp7 Col3a1 Smad2 Tgfb1 Tgfb2 Tgfb3
Survival:
Atm Bcl2l1 Bid Cxcl3 Dffb Fos Foxg1 2610018G03Rik Mt1 Mt2 Trp53 Trp73
Mesenchymal Markers:
Ddr2 Fn1 S100a4 Lama3 Cdh12 Cdh2 Cdh11 Sdc1 Vim Ctnnb1
Integrin-Mediated:
Col3a1 Ilk Itga5 Itgav Itgb1 Ptk2