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Fig. 1. RNA-seq relies on circular junction sequences for circRNA detection (top), which are too low in abundance for reliable and accurate quantification (bottom).
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Latest About Circular RNA in Cancer and Diseases
Cancers
• Circular RNA circPHLPP2 promotes tumor growth and anti-PD-1 resistance through binding ILF3 to regulate IL36γ transcription in colorectal cancer. Hu Y, et al. Molecular Cancer, 2024
• CircPDIA3/miR-449a/XBP1 feedback loop curbs pyroptosis by inhibiting palmitoylation of the GSDME-C domain to induce chemoresistance of colorectal cancer. Lin J, et al. Drug Resistance Updates, 2024
• TGF-β signaling promotes cervical cancer metastasis via CDR1as. Zhong G, et al.Molecular Cancer, 2023
CircPTEN suppresses human clear cell renal carcinoma progression and resistance to mTOR inhibitors by targeting epigenetic modification. Zhan Y, et al. Drug Resistance Updates, 2023
• CircNOLC1 Promotes Colorectal Cancer Liver Metastasis by Interacting with AZGP1 and Sponging miR-212-5p to Regulate Reprogramming of the Oxidative Pentose Phosphate Pathway. Yuan M, et al. Advanced Science, 2023
Diabetes
• CircRNA DICAR as a novel endogenous regulator for diabetic cardiomyopathy and diabetic pyroptosis of cardiomyocytes. Yuan Q, et al. Signal Transduction and Targeted Therapy, 2023
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