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R-Loops: An active player in transcription control


R-loop is an RNA:DNA three-stranded hybrid loop structure formed during nascent RNA transcription. R-loops are often located in the promoters or transcription stop sites and have important biological functions in gene regulation, DNA replication, and epigenomic modifications. In particular, lncRNAs in the R-loops are active components in the R-loop gene regulation activities. Genome-wide R-loop profiling by DRIP-seq, along with epigenomic and transcriptomic profiling, is an effective way to understand R-loops in the biological working of your system.

This webinar will cover:
  • What are the R-loops
  • The active gene regulation roles by R-loops
  • lncRNAs and mRNAs in the R-loops
  • Genome-wide R-loop profiling by DRIP-seq
  • Roadmap of R-loop profiling and research.
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