R-loop is an RNA:DNA three-stranded hybrid loop structure formed during nascent RNA transcription. R-loops are often located in the promoters or transcription stop sites and have important biological functions in gene regulation, DNA replication, and epigenomic modifications. In particular, lncRNAs in the R-loops are active components in the R-loop gene regulation activities. Genome-wide R-loop profiling by DRIP-seq, along with epigenomic and transcriptomic profiling, is an effective way to understand R-loops in the biological working of your system.
This webinar will cover:
- What are the R-loops
- The active gene regulation roles by R-loops
- lncRNAs and mRNAs in the R-loops
- Genome-wide R-loop profiling by DRIP-seq
- Roadmap of R-loop profiling and research.