What are DoG RNAs?
Downstream-of-gene (DoG) RNAs are RNA transcripts that arise downstream of ~10% of host genes and are continuous with their upstream RNAs [1]. DoGs are defined as having a minimal length of 5 kb beyond the polyadenylation signal (PAS) at transcription end site (TES), with maximal length up to 200 kb in mammalian cells [1]. Due to their extended lengths, DoGs often overlap with other downstream transcription units referred to as read-in genes.
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DoG RNAs modulate gene transcription in diseases
- DoG RNAs control the transcription of antisense overlapping genes in cell senescence
- DoG RNAs affect genome 3D organization in viral infection
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DoG-derived chimera RNAs and circular RNAs in cancers and diseases
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DoG RNAs are subject to m6A, R-loop, or epigenetic regulation
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Arraystar Human Downstream-of-Gene Transcript (DoG RNA) Microarray is designed to profile and study human DoG RNAs. The array includes more than 13,000 probes to simultaneously detect and quantify DoG RNAs, pre-mRNAs of the host genes, and downstream overlapping transcripts as their potential regulatory targets at high accuracy and specificity.