Print |

You have not viewed any products recently.

 

LncRNA Research

Gold Standard LncRNAs and Reliable LncRNAs

 

Unlike protein coding genes, publically available lncRNAs are often scantily annotated, partial in scope and scattered in collection. Arraystar maintains high quality proprietary transcriptome and lncRNA databases to extensively collect lncRNAs through our lncRNA discovery pipelines, external data sources, and knowledge-based mining of scientific publications. Arraystar Human LncRNA Array V4.0 has a total of 40,173 lncRNAs in two major lncRNA collections, 7,506 for Gold Standard LncRNAs and 32,667 Reliable LncRNAs, from more than 47 Tb worth of RNA-seq data and all major public databases and repositories, such as Refseq, USCS Known Genes, GENCODE, lincRNA catalogs, lncRNAdb, T-UCRs, RNAdb, NRED, and scientific publications.

The Gold Standard lncRNAs are well annotated and experimentally validated genuine lncRNAs, compared to very large numbers of partial fragments, incomplete UTRs, and less reliable lncRNA sequences deposited in public databases. The lncRNAs are complete with the information of lncRNA transcription units, transcript isoforms, functional molecular mechanisms and subcellular localizations. They are selected from:

• lncRNAdb v2.0 compilation as the reference database for functional  lncRNAs [1];

• Arraystar's continuous scientific publication review and selection;

• Level 1 GENCODE v21 LncRNAs with experimental support by RT-PCR-Seq and manual curation [2];

• Refseq full length high confidence LncRNAs under stringent selection;

• Arraystar lncRNA complete transcripts with 5'TSS, 3'ends and expression data defined by ENCODE CAGE Clusters, PolyA-seq, deep RNA-Seq and capture seq [3, 4].

The Reliable lncRNAs are the remaining lncRNA sequences from databases and publications merged into transcription units (TU). One best representative lncRNA is selected from each TU based on the transcript source, length and other available information. 32,667 Reliable LncRNAs are constructed from 308,525 lncRNA sequences.


Related Services
LncRNA Array Service

SE-lncRNA Array Service
LncPath™ Array Service
T-UCR Array Service



Reference
1. Quek X.C. et al. (2015) Nucleic Acids Res. 43(Database issue):D168-73 [PMID: 25332394]
2. Howald C. et al. (2012) Genome Res. 22(9):1698-710 [PMID: 22955982]
3. Clark M.B. et al. (2015) Nat. Methods 12(4):339-42 [PMID: 25751143]
4. Iyer M.K. et al. (2015) Nat. Genet. 47(3):199-208 [PMID: 25599403]

 

 

Back to news

Publications >>

Circular RNAs as biomarkers in liquid biopsy in colorectal cancer. Valladares-Ayerbes M, et al.  Journal of Clinical Oncology, 2020​Full text>>

Defining the adult neural stem cell niche proteome identifies key regulators of adult neurogenesis. Kjell J, et al. Cell Stem Cell, 2020
Full text>>

 

Promotion >>

LncRNA Array Service
- Unparalleled accuracy, newest databases and dedicated annotations

Promo: 20% OFF

Learn more>>

 

Brochures >> 

Arraystar Single Nucleotide Microarrays
- Locate and quantify the exact m6A site

Arraystar_m6A_Single_Nucleotide_Array_Web-1

Download.pdf

 

Webinars >>

The Latest Development of LncRNA Profiling Technology

LncRNA_Profiling_Technology

Watch video


tRNAs - The Rising Star of Wobble Gene Regulators
- nrStar™ tRNA PCR Arrays

tRNA_wobble_gene_regulators

Watch video


The Only Practical Choice for Circular RNA Profiling

Watch video