| Novel Master RNA Regulators - A Gold Mine to Be Unfolded ! |
|
What are super enhancer lncRNAs?
Super-enhancer lncRNA (SE-lncRNAs), emerging as a novel class of master RNA regulators, is a special set of long noncoding RNAs transcribed from super-enhancer genomic loci. SE-lncRNAs, together with super-enhancers, activate the nearby gene expression by mechanisms of transcription factor trapping, chromatin looping, chromatin modification, PolII loading, and release of transcriptional repressor (Fig. 1). Also, SE-lncRNAs are increasingly found to trans-activate target genes [1].
Master regulator RNAs in biology and
disease
|
Fig. 1. SE-lncRNAs activate the target gene promoter by multiple mechanisms
|
Super-enhancer lncRNAs play master regulatory roles in diverse gene expression programs that ultimately determine the cell types, cell identities, and diseases. For example, SE-lncRNAsCERNA and DRRRNA auto-regulate the master transcription factor MyoD and myogenic genes to turn on myogenesis [2]. Many SE-lncRNAs are intimately involved in cancers. A good example can be CCAT1-L, upstream of MYC gene. It mediates enhancer-promoter loop formation, activates MYC expression and promotes colorectal cancer progression [3].
The super-enhancer lncRNAs, emerged from hidden just recently, are now a scientific gold mine in the research of any fields of biology and disease. Arraystar has developed the SE-lncRNA profiling solution to simultaneously profile SE-lncRNAs, target genes, transcription factors and oncogenes, to accelerate the investigation of SE lncRNAs and the coding genes under their control.
|
References
[1] Alvarez-Dominguez J.R. et al. (2017) Cell Rep [PMID: 28636939]
[2] Mousavi K. et al. (2013) Mol. Cell [PMID: 23993744]
[3] Xiang J.F. et al. (2014) Cell Res. [PMID: 24662484]
|
|
 
|
|