| Unlock LncRNA functions, regulatory mechanisms and molecular pathology.
Long non-coding RNAs (LncRNAs) are a class of non-protein coding RNAs longer than 200 nt. By various mechanisms, lncRNAs are often regulatory molecules of gene expression, exerting multitudes of biological functions and associated with many human diseases [1-6]. Although the majority of lncRNAs are still functionally unknown, intense lncRNA research has characterized and accumulated functional and disease information for many lncRNAs.
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Arraystar has designed nrStar™ Human Functional LncRNA PCR Array to sensitively and accurately profiles 372 best known functional lncRNAs that have been characterized for the biological functions and association with human diseases. Profiling these lncRNA expression provides a key to their functions, regulatory mechanisms, molecular pathology and biomarker applications in you biological or disease systems.
Highlights
- Most comprehensive and best content: 372 known functional or disease lncRNAs curated from scientific publications and authoritative databases.
- High performance transcript-specific primer design: To achieve upmost sensitivity, specificity and accuracy.
- "Smart" cDNA synthesis strategy: For efficient and robust detection of polyadenylated and non-polyadenylated LncRNAs, whether in intact or degraded RNA samples.
- LncRNA analysis and annotation: Cross-referenced key information of lncRNA classification, mechanisms of action, biological functions, disease associations, clinical uses and scientific publications with the data.
Table 1 | A snapshot of lncRNAs on the PCR array with potential biomarker applications
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LncRNA
|
Disease Association
|
Biomarker application
|
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CDKN2B-AS1
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Coronary artery disease[1, 2]
|
Risk factor
|
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CDKN2B-AS1
|
Myocardial infarction[2]
|
Risk factor
|
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KCNQ1OT1
|
Myocardial infarction[3]
|
Predicts left ventricular dysfunction
|
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MIAT
|
Myocardial infarction[4]
|
Risk factor
|
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MT-LIPCAR
|
Myocardial infarction[5]
|
Predicts postinfarct remodeling
|
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SOX2OT
|
Alzheimer's disease[6]
|
Risk factor
|
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H19
|
Parkinson's Disease[7]
|
Risk factor
|
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HULC
|
Hepatocellular carcinoma[8]
|
Diagnosis and monitoring
|
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FALEC
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Ovarian cancer[9]
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Predicts poor prognosis
|
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CCAT1
|
Colorectal cancer[10]
|
Predicts therapeutic responsiveness
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References
- Fatica A. and I. Bozzoni (2014) "Long non-coding RNAs: new players in cell differentiation and development." Nat. Rev. Genet. 15(1):7-21 [PMID: 24296535]
- Devaux Y. et al. (2015) "Long noncoding RNAs in cardiac development and ageing." Nat Rev Cardiol 12(7):415-25 [PMID: 25855606]
- Satpathy A.T. and H.Y. Chang (2015) "Long noncoding RNA in hematopoiesis and immunity." Immunity 42(5):792-804 [PMID: 25992856]
- Knoll M. et al. (2015) "Long non-coding RNAs as regulators of the endocrine system." Nat Rev Endocrinol 11(3):151-60 [PMID: 25560704]
- Lorenzen J.M. and T. Thum (2016) "Long noncoding RNAs in kidney and cardiovascular diseases." Nat Rev Nephrol 12(6):360-73 [PMID: 27140855]
- Schmitt A.M. and H.Y. Chang (2016) "Long Noncoding RNAs in Cancer Pathways." Cancer Cell 29(4):452-63 [PMID: 27070700]
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