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Product NameCatalog NoSizePrice
nrStar™ Human Functional LncRNA PCR Array AS-NR-004-1 384-well/ plate $325.00 $260.00
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nrStar™ Human Functional LncRNA PCR Array (Roche Light Cycler 480) AS-NR-004-1-R 384-well/ plate $325.00 $260.00
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nrStar™ Mouse Functional LncRNA PCR Array AS-NR-004M-1 384-well (2*192) / plate $325.00 $260.00
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nrStar™ Mouse Functional LncRNA PCR Array (Roche Light Cycler 480) AS-NR-004M-1-R 384-well (2*192) / plate $325.00 $260.00
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• Well-known LncRNAs characterized for biological functions or disease association are comprehensively collected.

• Functional and disease LncRNAs are carefully categorized, annotated and cross-referenced.

• All the primer sets are fully validated in numerous sample types to meet the needs of biomarker discovery.

• Transcript-specific PCR primers enable unambiguous and accurate detection of each individual LncRNA isoforms.

We recommend using our rtStar™ First-Strand cDNA Synthesis Kit  (AS-FS-001) along with Arraystar SYBR® Green Real-time qPCR Master Mix when running your nrStar™ Functional LncRNA PCR Arrays for optimal performance.

• Best coverage for known functional lncRNAs: Well-known LncRNAs characterized for biological functions or human disease association are comprehensively collected from the most updated public databases and landmark publications. 

Figure 1. Some lncRNAs associated with cancers were collected from Bartonicek et al. 2016. 

Figure 2. Some LncRNAs involved in cardiac pathways were collected from Devaux et al. 2015

• Comprehensive annotations: The LncRNAs that have been associated with diseases including cancers, cardiovascular diseases and neurodegenerative diseases are carefully categorized, annotated and cross-referenced.

Function_lncRNA_table_1
Table1. The annotated information includes:
                  Class based on genomic location: [enhancer, antisense, intergenic, intronic, bidirectional...]
                  Target mRNA genes
                  Mechanisms: [signal, decoy, scaffold, guide, ceRNA, miRNA sponge, splicing ...]
                  Biological functions: [cell cycle, differentiation, methylation, immune, metabolism...]
                  Diseases: [cancers, cardiovascular, neurodegenerative, kidney, diabetes, syndromes...] 

    Annotation Example 1 - Cancer-associated lncRNA NBAT-1

    
    Figure 3. Information of NBAT-1 annotated by Arraystar is shown in the green rectangular area.

    Annotation Example 2 - LncRNA Mhrt in cardiovascular diseases

    
    Figure 4. Information of MHRT annotated by Arraystar is shown in the blue rectangular area.

    Annotation Example 3 – LncRNA BACE1-AS in neurodegenerative diseases

    
     Figure 5. Information of BACE1-AS annotated by Arraystar is shown in the red rectangular area.

• A powerful tool for biomarker screening and validation: All the primer sets are optimized and fully validated experimentally using numerous sample types, to meet the needs of biomarker discovery.

Functional_Biomarker

Figure 6. A snippet of the lncRNAs on the PCR array with published biomarker potentials and utilities.

• Transcript-specific detection: Transcript-specific PCR primers are designed to target the specific exon or splice junction sites, for unambiguous and accurate detection of each individual LncRNA isoforms.

• Most reliable and accurate quantification: Each lncRNA is quantified at high accuracy and data quality, by using external controls (RNA Spike-In, and positive PCR control), Genomic DNA Control and six internal housekeeping genes. Normalization is performed by geometric means of multiple reference genes selected by experimentally validated algorithm, instead of a single reference gene. 

• Fast and easy: Ready-to-use PCR array in a 384-well plate format. The entire process can be completed in less than 4 hours.

Human Functional LncRNA List

Cancer:
7SK, AA174084, AB073614, ABHD11-AS1, ACTA2-AS1, ADAMTS9-AS2, AF339813, AFAP1-AS1, AIRN-1, AIRN-2, AK095147, AP5M1, APOC1P1, ARA-1, ARA-2, ATG9B-1, ATG9B-2, BANCR, BCAR4-1, BCAR4-2, BGLT3, BLACAT1, BOK-AS1, C5orf66-AS1, CASC11-1, CASC11-2, CASC2-1, CASC2-2, CASC9, CBR3-AS1-1, CBR3-AS1-2, CCAT1, CCAT2, CCDC26, CCEPR, CRNDE, CTB-89H12.4, CTBP1-AS, DLEU1-1, DLEU1-2, DNM3OS-1, DNM3OS-2, DRAIC (LOC145837), DSCAM-AS1-1, DSCAM-AS1-2, EGFR-AS1, EGOT, ENST00000434223, ENST00000456816, ENST00000480739, EPB41L4A-AS1, EPB41L4A-AS2, EWSAT1, FALEC, FAS-AS1 (SAF), FER1L4, FEZF1-AS1, FGF14-AS2, FLG-AS1-1, FLG-AS1-2, FOXCUT, FTX, GACAT1-1, GACAT1-2, GACAT2, GACAT3, GAPLINC-1, GAPLINC-2, GAS5, GAS8-AS1, GATA6-AS1, GHET1, H19-1, H19-2, HAGLR, HAND2-AS1, HCP5, HIF1A-AS1, HIF1A-AS2, HNF1A-AS1, HOTAIR-1, HOTAIR-2, HOTAIR-3, HOTAIRM1-2, HOTTIP, HOXA-AS2 , HULC, KCNQ1OT1, KRASP1, KRT18P55, KRT7-AS, L1PA16, LINC00032, LINC00152-1, LINC00152-2, LINC00152-3, LINC00312, LINC00467, LINC00473, LINC00668, LINC00673, LINC00857, LINC00901 , LINC00951, Linc00963, LINC00970, LINC01133, LINC01315-1, LINC01315-2, LINC01630-1, LINC01630-2, LINC-PINT, Linc-POU3F3-1, Linc-POU3F3-2, lincRNA-p21, lincRNA-RoR, lncRNA-CTD903, lncRNA-HEIH, LOC100130476, LOC100507661 , LOC101054525 , LOC389332, LSINCT5, LUCAT1, LUNAR1, LUST, MACROD2-AS1-1, MACROD2-AS1-2, MEG3-1, MEG3-2, MER11C, MIAT, MINA, MIR100HG, MIR155HG, MIR17HG, MIR31HG, MT1JP, MYCNOS-1, MYCNOS-2, MYCNUT, NAMA-1, NAMA-2, NBAT-1, NDM29, NEAT1-1, NEAT1-2, NKILA, NPTN-IT1, OR3A4P, ORAOV1, PACERR, PANDAR, PARROT, PAX8-AS1-1, PAX8-AS1-2, PCA3-1, PCA3-2, PCAT-1, PCAT18, PCAT29, PCAT6-1, PCAT6-2, PCBP2-OT1, PCGEM1, PGM5-AS1-1, PGM5-AS1-2, PICSAR, PINC, POU6F2-AS2, PRNCR1, PSF inhibiting RNA, PTCSC1, PTCSC3, PTENP1, RGMB-AS1, RMEL3, RUNX1-IT1, SAMMSON , SBF2-AS1, SCHLAP1, SNHG1, SNHG15, SNHG16, SNHG20, SNHG5, SOX2OT, ST7-AS1, ST7-AS2-1, ST7-AS2-2, ST7-OT3, ST7-OT4, SUMO1P3, TARID, TCL6, TDRG1, TERC, TIE1-AS, TRERNA1, TRIM52-AS1-1, TRIM52-AS1-2, TUG1-1, TUG1-2, TUSC7 , TUSC8, U79277, uc.338, uc.73A(P), UCA1, UFC1 lincRNA , VLDLR-AS1, WSPAR, WT1-AS-1, WT1-AS-2, WT1-AS-3, X91348, Yiya, ZEB2-AS1, ZFAS1-1, ZNF582-AS1-1, ZNF582-AS1-2, ZNF582-AS1-3
Neurodegenerative diseases:
17A, 51A, anti-NOS2A, ATXN8OS , BACE1-AS, BDNF-AS-1, BDNF-AS-2, CDKN2B-AS1, DGCR5, DLX6-AS1, DPY19L2P2-1, DPY19L2P2-2, GDNF-AS1 -1, H19-1, H19-2, HAR1A, HAR1B (HAR1R), HTT-AS, LINC00299, LINC00599, LINC01262, lincRNA-p21, MALAT1, MEG3-1, MEG3-2, MIAT, NAT-RAD18, NEAT1-1, NEAT1-2, PINK1-AS, PNKY, RMST, SCAANT1, SNHG1, SNHG3, SOX2OT, TUG1-1, TUG1-2, TUNA-1, TUNA-2, U1 spliceosomal lncRNA, UCH1LAS    
Cardiovascular diseases:
7SK, ALIEN, ATG9B-1, ATG9B-2, CARMEN-1, CDKN2B-AS1, EMX2OS, FENDRR, FGF10-AS1, GAS5, H19-1, H19-2, HAS2-AS1, HIF1A-AS1, HIF1A-AS2, HOTAIR-1, HOTAIR-2, HOTAIR-3, KCNQ1OT1, LINC00323, lincRNA-p21, LOC100129973, LOC100507537, MHRT, MIAT, MIR222HG, NONHSAT073641, NONHSAT112178, Novlnc35, Novlnc44, Novlnc76, NPPA-AS1, NRON, PANCR, PUNISHER, PVT1, SALRNA1, SENCR, SMILR, TERMINATOR, TIE1-AS, TUG1-1, TUG1-2, UCA1  
Kidney diseases:
ENST00000456816, GAS5, H19-1, H19-2, HIF1A-AS1, HIF1A-AS2, HOTAIR-1, HOTAIR-2, HOTAIR-3, KCNQ1OT1, LOC389332, MEG3-1, MEG3-2, PVT1, RP11-354P17.15-001, TapSAKI, X91348
Diabetes:
CDKN2B-AS1, HI-LNC25-1, HYMAI, IGF2-AS-1, LINC00271, MEG3-1, MEG3-2, NONRATT021972, PDZRN3-AS1, PVT1   
Immune system:
GATA3-AS1-1, GATA3-AS1-2, GATA3-AS1-3, IFNG-AS1-1, IFNG-AS1-2, Linc-DC , lincRNA-EPS, M18204, MAFTRR, NRAV, NRIR, NTT, PACERR, RHOXF1P1, THRIL
Cell Cycle:
CCND1 associated ncRNAs, CDKN2B-AS1, H19-1, H19-2, HULC, KCNQ1OT1, lincRNA-p21, lincRNA-RoR, lncRNA-HEIH, PANDAR, TUSC7
Lipid metabolism and adipogenesis:
APOA1-AS, HOTAIR-1, HOTAIR-2, HOTAIR-3, HULC, NEAT1-1, NEAT1-2, RP1-13D10.2


Mouse Functional LncRNA List

Cancer:
9530018H14Rik; Airn-1; Airn-2; Airn-3; C130071C03Rik-1; C130071C03Rik-2; Dreh; Esrp2-as-1; Esrp2-as-2; Esrp2-as-3; H19; Hottip-1; Hottip-2; Lncpint-1; Lncpint-2; Lncpint-3; lncRNA-Smad7-1; lncRNA-Smad7-2; lncRNA-Smad7-3; Malat1; Meg3-1; Meg3-2; Mira; Pinc; Trp53cor1
Cardiac development & cardiovascular diseases:
4930503E24Rik; AK028007; AK038798; AK044955; AK139328; AK143294; AK143693; AK153778; Atp2a2; Bvht; C2dat1; CAIF; Chaer; Cyp4b1-ps2; Chast; Dworf; Fendrr-1; Fendrr-2; Gm12919; Gm13865; Gm14155; Gm15054; Gm15834; Gm32592; Gm6644; Gm6768; LeXis-1; LeXis-2; Meg3-1; Meg3-2; Mhrt; Mirt1; Sghrt-1; Sghrt-2; Srsf9; Tdpx-ps1; TK99129; Uph; Wt1os
Diabete:
LincRNA-Gm4419-1; LincRNA-Gm4419-2; Meg3-1; Meg3-2; Pluto; Rian
Embryonic Stem Cell Pluripotency & Differentiation:
1700007L15Rik; Digit; Evx1as; G730013B05Rik-1; G730013B05Rik-2; Gm16845-1; Gm16845-2; Gm2694-1; Gm2694-2; Halr1; linc1242; linc1257-1; linc1257-2; linc1368; Panct1; Snhg3
Genomic imprinting:
Kcnq1ot1; Nctc1; Nespas
Immune system development & immune response & immune disease:
Gas5; Lnc13; lncKdm2b; lncRNA-ACOD1; lncRNA-Nfkb2-1; lncRNA-Nfkb2-2; lnc-Smad3; Malat1; Mir142hg; Mirt2; Morrbid-1; Morrbid-2; Morrbid-3; Ptgs2os2; Rmrp; Rroid
Kidney diseases:
np_17856, np_5318, Xist-1; Xist-2
Liver diseases:
Airn-1; Airn-2; Airn-3; APOA4-AS; lnc-LFAR1
Lipid metabolism & adipogenesis & adipocyte differentiation:
C730029A08Rik; C730036E19Rik; Gm15050; Gm16551
Neuronal development & Differentiation & Diseases:
4930570G19Rik-1; 4930570G19Rik-2; Abhd11os; AK133808; Dalir; Dleu2; Dlx1as; Egr2-AS; Gm30731; lncOL1; lncOL1; Miat-1; Miat-2; Nkx2-2os; Paupar; Rmst; Six3os1-1; Six3os1-2; Six3os1-3; Six3os1-4; Six3os1-5; Six3os1-6; Sox2ot; Uchl1os
rRNA metabolism:
5S-OT, PAPAS
Spermatogonial stem cells survival & spermatogenesis & infertility:
Gfra1; Hm629797; lncRNA033862; Neat1-1; Neat1-2
Skeletal & muscle development:
LOC105246506; lnc-31; Msx1os; Munc; Myhas; Yam-1
X inactivation:
Firre; Ftx-1; Ftx-2; Jpx; Rr18; Tsix; Xist-1; Xist-2
Other biological functions & diseases:
6430411K18Rik; AK081227; alncRNA-EC7; CAIF; Egr2-AS; Hotair; Hoxaas3; lncLGR; Mdrl; Mir124a-1hg; Neat1-1; Neat1-2; Rubie; Smn-AS1; Snhg5; Tog; Ttc39aos1; Tug1-1; Tug1-2; Tug1-3; Vax2os-1; Vax2os-2

Suffix (-1, -2, -3 …) represents different transcript isoforms of the lncRNA genes.  

 

LncRNA-Workflow

Figure 1. Workflow of nrStar™ Functional LncRNA PCR Array

 

Compatible qPCR Instruments:

ABI ViiA™ 7
ABI 7500 & ABI 7500 FAST
ABI 7900HT
ABI QuantStudio™ 6 Flex Real-Time PCR system
ABI QuantStudio™ 7 Flex Real-Time PCR system
ABI QuantStudio™ 12K Flex Real-Time PCR System
Bio-Rad CFX384
Bio-Rad iCycler & iQ Real-Time PCR Systems
Eppendorf Realplex
QIAGEN Rotor Gene Q 100
Roche LightCycler 480
Stratagene Mx3000
Roche LightCycler 480

 

LncRNA ZEB2-AS1 promotes pancreatic cancer cell growth and invasion through regulating the miR-204/HMGB1 axis. Gao H, et al. International journal of biological macromolecules, 2018