Arraystar's bioinformatics team has extensive experience in analyzing MeDIP-chip data. We provide our customers with thorough, comprehensive data analysis, including:
• Methylation Enrichment Peak (EP) finding
• Defferentially Enriched Peak (DEP) analysis
• The promoters are annotated into three classes: High-CpG density promoters (HCP), low-CpG density promoters (LCP) and intermediate-CpG-density promoters (ICP), based on the CpG ratio, GC content and the length of the CpG-rich region, which is an excellent predictor of transcriptional repression.
Table 1. Results of a MeDIP-chip experiment that uncovered genes whose promoters contain methylated CpG islands. . Each gene is listed in the column on the left. The promoter type (LCP, ICP, or HCP) is indicated in the column highlighted by the blue box.
• Differentially methylated region analysis by ROI (Advanced analysis with extra fees applied)
Table 2. Differentially methylated region of interest between two groups.
MSC Transplantation Improves Osteopenia via Epigenetic Regulation of Notch Signaling in Lupus. Shiyu Liu, et al. Cell Metabolism, 2016
Long-term parental methamphetamine exposure of mice influences behavior and hippocampal DNA methylation of the offspring. Y Itzhak, et al. Molecular Psychiatry, 2014
TFIIS. h, a new target of p53, regulates transcription efficiency of pro-apoptotic bax gene. JM Liao, et al. Scientific Reports, 2016
Epigenetic inactivation of the CpG demethylase TET1 as a DNA methylation feedback loop in human cancers. Li L, et al. Scientific reports, 2016
Characterization of the nasopharyngeal carcinoma methylome identifies aberrant disruption of key signaling pathways and methylated tumor suppressor genes. Li L, et al. Epigenomics, 2014
Long lasting alterations to DNA methylation and ncRNAs may underlie the effects of fetal alcohol exposure. Benjamin I. Laufer, et al. Disease Models & Mechanisms, 2013
Sox9 transcriptionally regulates Wnt signaling in intestinal epithelial stem cells in hypomethylated crypts in the diabetic state. Huang C Z, et al. Stem Cell Research & Therapy, 2017
Increased 5-hydroxymethylation levels in the hippocampus of rat extinguished from cocaine self-administration. Sadakierska-Chudy A, et al. Hippocampus, 2017
DNA methylation differences in monozygotic twin pairs discordant for schizophrenia identifies psychosis related genes and networks. Castellani CA, et al. BMC Med Genomics, 2015
Dietary Chromium Restriction of Pregnant Mice Changes the Methylation Status of Hepatic Genes Involved with Insulin Signaling in Adult Male Offspring. Zhang Q, et al. PLOS ONE, 2017
Olanzapine-induced methylation alters cadherin gene families and associated pathways implicated in psychosis. MG Melka, et al. BMC Neuroscience, 2014
Epigenetic modification of TLE1 induce abnormal differentiation in diabetic mice intestinal epithelium. Xu J,et al. Molecular and Cellular Biochemistry, 2017
Genome-Wide DNA Methylation in Mixed Ancestry Individuals with Diabetes and Prediabetes from South Africa. Matsha T E, et al. International Journal of Endocrinology, 2016
Olanzapine-induced DNA methylation in the hippocampus and cerebellum in genes mapped to human 22q11 and implicated in schizophrenia. MG Melka, et al. Psychiatric genetics, 2014