Neurodegenerative disorders are often accompanied by widespread changes in gene regulatory networks. Recent studies have found that these changes are not restricted to protein-coding genes, but also include long non-coding RNAs (LncRNAs). Accumulating evidences have shown that LncRNAs are widely expressed in the mammalian nervous system, and the aberrant expression of LncRNAs is implicated in neurodegenerative diseases, including Alzheimer’s (AD) and Huntington’s disease (HD). However, the functional roles of LncRNAs and their underlying regulatory mechanisms in neurodegenerative diseases are still largely unknown.

The LncPath™ Human Neurodegenerative Disease Array simultaneously profiles the expression of 1,168 LncRNAs and 510 their potential coding targets related to the cardiovascular pathologies. The LncPath™ Mouse Neurodegenerative Disease Array simultaneously profiles the expression of 749 LncRNAs and 888 their potential coding targets related to the cardiovascular pathologies. The LncRNAs whose gene loci are located at or near the protein-coding genes critical in cardiovascular disease pathways, and LncRNAs which have high possibility as the potential ceRNA of the key genes involved in cardiovascular pathologies, are carefully selected from authoritative databases by using a rigorous process. By limiting the number of LncRNAs most relevant to cardiovascular diseases, this array can achieve much faster analysis with greater precision due to the highly specific, yet smaller amount of data to analyze. More importantly, it can establish the expression relationship between LncRNAs and their potential protein-coding targets involved in the cardiovascular diseases, thereby providing comprehensive insights into the underlying regulatory mechanisms of LncRNAs in cardiovascular pathologies.

• Reliable neurodegenerative disease focus LncRNA collection

• Simultaneous analysis of LncRNAs and their potential coding gene targets related to the neurodegenerative diseases.

• Efficient and robust labeling system

• Innovative probe design

• Guaranteed performance

An example showing the detailed information about the LncRNAs and their potential coding gene target

Click the LncRNA accession number listed in databases, you will see the figures showing the detailed information about the LncRNAs and their potential target gene.

Figure 1. The genomic map views of the LncRNA ENST00000435915 and its potential target gene ABCA1. From the top to the bottom of the figure 1, the following items are displayed:

Genome view: A chromosome ideogram showing the map position of the LncRNA ENST00000435915 and its potential target gene ABCA1(red bar).

Map view ruler: The map coordinates of the human genome assembly hg19 for the map views below.

LncRNA map view: The LncRNAs whose genes located at or near the ABCA1 gene are presented in the Noncoding panel (shaded green). The LncRNAs are indicated by the transcript IDs, the exons by solid blocks, the introns by thin lines, and the transcription directions by arrows. The exons of LncRNA ENST00000435915 are labeled in red, while the exons of the other LncRNAs are labeled in blue.

Coding gene map view: The coding gene ABCA1 is presented in the Coding panel (shaded blue). The coding gene is indicated by its canonical transcript ID, the exons by solid blocks, the introns by thin lines, and the transcription direction by arrows.

Figure 2. The relationship between LncRNA ENST00000435915 and its protein coding gene target ABCA1. The other neighboring LncRNAs which may regulate ABCA1 expression are also shown.

Figure 3. The LncRNA ENST00000534271 may function as a competing endogenous RNA (ceRNA) of the protein coding gene ABCA1.

* MuTaMe Score, Mutually Targeted MRE Enrichment Score [1].

References

1.Tay, Y., et al., Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs. Cell, 2011. 147(2): p. 344-57.

LncRNA List

The human neurodegenerative disease focused LncRNAs are listed in Table 1. Click the LncRNA accession numbers to see the detailed information about the LncRNAs and their potential coding gene targets in neurodegenerative diseases.

Table 1. Human Neurodegenerative disease focused LncRNAs

Full List of Human Neurodegenerative Disease Related LncRNAs.pdf

Gene List

The potential gene targets of human neurodegenerative disease focused LncRNAs are listed in Table 2. Click the protein gene names to see the detailed information about the genes and their corresponding regulatory LncRNAs in the neurodegenerative diseases.

Table 2. Functional gene grouping

LncRNA List

The mouse neurodegenerative disease focused LncRNAs are listed in Table 1. Click the LncRNA accession numbers to see the detailed information about the LncRNAs and their potential coding gene targets in neurodegenerative diseases.

Table 1. Mouse Neurodegenerative disease focused LncRNAs

Full List of Mouse Neurodegenerative Disease Related LncRNAs.pdf

Gene List

The potential gene targets of mouse neurodegenerative disease focused LncRNAs are listed in Table 2. Click the protein gene names to see the detailed information about the genes and their corresponding regulatory LncRNAs in the neurodegenerative diseases.

Table 2. Functional gene grouping