The Hippo pathway is an evolutionarily conserved pathway that regulates cell proliferation, apoptosis, stem cell self-renewal, and tissue regeneration. Dysregulation of the Hippo pathway contributes to a broad range of human carcinomas, including lung, colorectal, ovarian, breast and liver cancer [1]. Understanding of the Hippo pathway regulation may shed new insights to novel strategies for cancer treatment.

The LncPath™ Human Hippo Pathway LncRNA Microarray simultaneously profiles the expression of 662 LncRNAs and 157 their potential coding targets related to the Hippo signaling pathway. The LncPath™ Mouse Hippo Pathway LncRNA Microarray simultaneously profiles the expression of 379 LncRNAs and 267 their potential coding targets related to the Hippo signaling pathway. The LncRNAs whose genes are located at or near the protein-coding genes critical in the Hippo pathway, and the LncRNAs that have high possibilities of being competing endogenous RNAs (ceRNAs) of the key Hippo pathway genes, are carefully collected from authoritative databases using rigorous selection processes. By focusing on the LncRNAs most relevant to the Hippo pathway, the array can achieve much faster and more precise analysis, due to the highly specific yet smaller amount of data to analyze. More importantly, it can establish the expressional relationships between the LncRNAs and their protein-coding gene targets involved in the Hippo signaling pathway, thereby providing comprehensive insights into the underlying regulatory mechanisms of LncRNAs in the Hippo pathway.

• Comprehensive and reliable collection of Hippo pathway focused LncRNAs.

• Simultaneous analysis of LncRNAs and their protein-coding gene targets in the Hippo pathway.

• Explore and establish expressional relationships and regulatory mechanisms between the LncRNAs and the target pathway genes.

• Faster and more precise pathway-focused analysis.

• Efficient and robust labeling system.

• Innovative probe design.

• Guaranteed performance.

An example showing the detailed information about the LncRNAs and their potential coding gene target

Click the LncRNA accession number listed in databases, you will see the figures showing the detailed information about the LncRNAs and their potential target gene.

Figure 1. The genomic map views of the LncRNA ENST00000430912 and its potential target gene ACTG1. From the top to the bottom of the figure 1, the following items are displayed:

Genome view: A chromosome ideogram showing the map position of the LncRNA ENST00000430912 and its potential target gene ACTG1 (red bar).

Map view ruler: The map coordinates of the human genome assembly hg19 for the map views below.

LncRNA map view: The LncRNAs whose genes located at or near the ACTG1 gene are presented in the Noncoding panel (shaded green). The LncRNAs are indicated by the transcript IDs, the exons by solid blocks, the introns by thin lines, and the transcription directions by arrows. The exons of LncRNA ENST00000430912 are labeled in red, while the exons of the other LncRNAs are labeled in blue.

Coding gene map view: The coding gene ACTG1 is presented in the Coding panel (shaded blue). The coding gene is indicated by its canonical transcript ID, the exons by solid blocks, the introns by thin lines, and the transcription direction by arrows.

Figure 2. The relationship between LncRNA ENST00000430912 and its protein coding gene target ACTG1. The other neighboring LncRNAs which may regulate ACTG1 expression are also shown.

Figure 3. The LncRNA TCONS_00006371 may function as a competing endogenous RNA (ceRNA) of the protein coding gene ACTG1.

* MuTaMe Score, Mutually Targeted MRE Enrichment Score.

References
1.Harvey, K. F., et al. (2013) Nat Rev Cancer 13 (4): 246-57.
2.Tay, Y., et al. (2011) Cell 147 (2): 344-57.

List of LncRNAs

The LncRNAs collected for the human Hippo pathway are listed in Table 1. Click an LncRNA accession number to see its detailed information and its potential target gene(s) in the Hippo pathway.

Table 1. Human Hippo pathway focuse LncRNAs

Full List of Human Hippo Pathway Focused LncRNAs.pdf

Gene List

The potential gene targets of human Hippo pathway focus LncRNAs are listed in Table 2. Click the protein gene names to see the detailed information about the genes and their corresponding regulatory LncRNAs in the Hippo pathway.

Table 2. Functional gene grouping

List of LncRNAs

The LncRNAs collected for the mouse Hippo pathway are listed in Table 1. Click an LncRNA accession number to see its detailed information and its potential target gene(s) in the Hippo pathway.

Table 1. Mouse Hippo pathway focuse LncRNAs

Full List of Mouse Hippo Pathway Focused LncRNAs.pdf

Gene List

The potential gene targets of mouse Hippo pathway focus LncRNAs are listed in Table 2. Click the protein gene names to see the detailed information about the genes and their corresponding regulatory LncRNAs in the Hippo pathway.

Table 2. Functional gene grouping