LncPath™ Cardiovascular Disease Microarrays

Description
Highlights
Human Datasheet
Mouse DataSheet

Arraystar LncPath™ Cardiovascular Disease Microarray simultaneously profiles the expression of the LncRNAs in cardiovascular diseases and their protein-coding gene targets, to gain comprehensive insights into the underlying regulatory mechanisms of LncRNAs in cardiovascular pathophysiology.

Long non-coding RNAs (lncRNAs) are important regulators of gene expression. Recent studies have uncovered their vital roles in cardiovascular development and physiological functions [1, 2]. LncRNAs have been found aberrantly expressed under a variety of cardiovascular pathologies, including myocardial infarction, heart failure, coronary artery disease, stroke, diabetes and hypertension.

The LncPath™ Cardiovascular Disease Array simultaneously profiles the expression of 2,704 LncRNAs and 1,277 their protein-coding targets in the cardiovascular diseases. The LncPath™ Mouse Cardiovascular Disease Array simultaneously profiles the expression of 1,783 LncRNAs and 2,159 their protein-coding targets in the cardiovascular diseases. Using this kind of array, scientists can leverage the pre-designed panel as a powerful tool to quickly profile the expression of both the lncRNAs and their protein-coding gene targets, and gain comprehensive insights into the underlying regulatory mechanisms of LncRNAs in cardiovascular pathophysiology. The LncRNAs whose genes are located at or near the protein-coding genes critical in cardiovascular disease, and the LncRNAs that have high possibilities of being competing endogenous RNAs (ceRNAs) of the key cardiovascular disease genes, are carefully collected from authoritative databases using rigorous selection processes. By focusing on the LncRNAs most relevant to the cardiovascular diseases, the array can achieve much faster and more precise analysis, due to the highly specific yet smaller amount of data to analyze. More importantly, it can establish the expressional relationships between the LncRNAs and their potential protein-coding targets involved in the cardiovascular diseases, thereby providing comprehensive insights into the underlying regulatory mechanisms of LncRNAs in the cardiovascular pathophysiology.

Product Name	Catalog No	Description	Format	Price
LncPath™ Human Cardiovascular Disease Microarray	AS-LP-007H	2,704 LncRNAs and 1,277 potential coding targets	8*15K
LncPath™ Mouse Cardiovascular Disease Microarray	AS-LP-007M	1,783 LncRNAs and 2,159 potential coding targets	8*15K

• Comprehensive and reliable collection of cardiovascular disease focused LncRNAs.

• Simultaneous analysis of LncRNAs and their protein-coding gene targets in the cardiovascular diseases.

• Explore and establish expressional relationships and regulatory mechanisms between the LncRNAs and the target disease genes.

• Faster and more precise disease-specific analysis.

• Efficient and robust labeling system.

• Innovative probe design.

• Guaranteed performance.

An example showing the detailed information about the LncRNAs and their potential coding gene target

Click the LncRNA accession number listed in databases, you will see the figures showing the detailed information about the LncRNAs and their potential target gene.
CTNNA2
Figure 1. The genomic map views of the LncRNA ENST00000265882 and its potential target gene CTNNA2. From the top to the bottom of the figure 1, the following items are displayed:

Genome view: A chromosome ideogram showing the map position of the LncRNA ENST00000265882 and its potential target gene CTNNA2 (red bar).

Map view ruler: The map coordinates of the human genome assembly hg19 for the map views below.

LncRNA map view: The LncRNAs whose genes located at or near the CTNNA2 gene are presented in the Noncoding panel (shaded green). The LncRNAs are indicated by the transcript IDs, the exons by solid blocks, the introns by thin lines, and the transcription directions by arrows. The exons of LncRNA ENST00000265882 are labeled in red, while the exons of the other LncRNAs are labeled in blue.

Coding gene map view: The coding gene CTNNA2 is presented in the Coding panel (shaded blue). The coding gene is indicated by its canonical transcript ID, the exons by solid blocks, the introns by thin lines, and the transcription direction by arrows.

CTNNA2-2
Figure 2. The relationship between LncRNA ENST00000265882 and its protein coding gene target CTNNA2. The other neighboring LncRNAs which may regulate CTNNA2 expression are also shown.

CTNNA2-3
Figure 3. The LncRNA NR_038373 may function as a competing endogenous RNA (ceRNA) of the protein coding gene CTNNA2.
* MuTaMe Score, Mutually Targeted MRE Enrichment Score[3]

References
1.Schonrock, N., et al. (2012) Circ Res 111 (10): 1349-62.
2.Scheuermann, J. C. and L. A. Boyer (2013) EMBO J 32 (13): 1805-16.
3.Tay, Y., et al. (2011) Cell 147 (2): 344-57.

List of LncRNAs

The LncRNAs collected for the human cardiovascular diseases are listed in Table 1. Click an LncRNA accession number to see its detailed information and its potential target gene(s) in the cardiovascular diseases.

Table 1. Human cardiovascular disease LncRNAs

ENST00000254302, ENST00000265882, ENST00000289731, ENST00000292748, ENST00000305491, ENST00000312310, ENST00000312918, ENST00000320232, ENST00000320606, ENST00000333487, ENST00000339626, ENST00000343087, ENST00000354642, ENST00000366405, ENST00000369391, ENST00000369884, ENST00000371455, ENST00000378574, ENST00000380601, ENST00000381143, ENST00000389290, ENST00000392399, ENST00000392417, ENST00000395025, ENST00000395082, ENST00000398413, ENST00000400791, ENST00000400985, ENST00000405137, ENST00000407031, ENST00000407054, ENST00000407837, ENST00000408043, ENST00000412065, ENST00000412199, ENST00000412276, ENST00000412387, ENST00000412749, ENST00000412797, ENST00000412804, ENST00000412951, ENST00000412972, ENST00000413334, ENST00000413479, ENST00000413541, ENST00000413564, ENST00000413568, ENST00000413928, ENST00000414098, ENST00000414106,

Full List of Human Cardiovascular Disease Related LncRNAs.pdf

Gene List

The potential gene targets of human cardiovascular disease focused LncRNAs are listed in Table 2. Click the protein gene names to see the detailed information about the genes and their corresponding regulatory LncRNAs in the cardiovascular diseases.

Table 2. Functional gene grouping

Regulatory Genes Hormones:

AGT ANGPT2

Cell Growth and Proliferation Growth Factors and Receptors:

CSF2 KDR PDGFRB SPP1

Other Genes Related to Stress Response:

IFNG PPARG VEGFA

Other Genes:

HIF1A NOS3 SPHK1

Antioxidants Other Antioxidants:

ALB APOE GSR MT3 VIMP SOD1 SOD3 SRXN1 TXNRD1 TXNRD2

Response to Wounding:

CCR1 CCR2 CTGF FN1 PDGFB TNF VWF

Synthesis:

GBE1 GYS1 GYS2 UGP2

Adipogenesis Regulation Pro-Adipogenesis:

ACACB AXIN1 CCND1 CDK4 CEBPB CEBPD DKK1 E2F1 FABP4 FASN FGF1 FGF2 IRS2 JUN LMNA LPL PPARG RXRA SFRP1 SFRP5 SLC2A4 WNT5B

Anorectic Genes Pancreas Derived Peptides and Receptors:

CALCR CLPS GCG GCGR GLP1R IAPP INS INSR RAMP3 SST SSTR2

Cyclic-GMP Synthesis & Signaling:

ADRA1D GUCY1B3 PDE3B PRKG1 PRKG2 PTGIR S1PR1

Ubiquitin Ligases:

ANAPC1 CBLL1

Required for TNF-Induced Necrosis:

ATP6V1G2 BMF C1orf159 CCDC103 COMMD4 CYLD DEFB1 DENND4A DPYSL4 EIF5B FOXI1 GALNT5 GRB2 HSPBAP1 JPH3 KCNIP1 MAG OR10J3 PARP2 PVR RAB25 S100A7A SPATA2 SYCP2 TMEM57 TXNL4B

Chemokines:

C5 CCL1 CCL11 CCL13 CCL15 CCL16 CCL17 CCL2 CCL20 CCL22 CCL23 CCL24 CCL26 CCL3 CCL4 CCL5 CCL7 CCL8 CX3CL1 CXCL1 CXCL10 CXCL11 CXCL12 CXCL13 CXCL2 CXCL3 CXCL5 CXCL6 CXCL9

Acyl-CoA Dehydrogenases:

ACAD10 ACAD11 ACAD9 ACADL ACADM ACADS ACADSB ACADVL EHHADH GCDH

Nitric Oxide Signaling:

AGT AGTR2 GUCY1A3 GUCY1B3 NOSIP NOSTRIN

Antioxidants Peroxiredoxins (TPx):

PRDX1 PRDX2 PRDX3 PRDX4 PRDX5 PRDX6

Adipogenesis Regulation Anti-Adipogenesis:

ADRB2 CDKN1A CDKN1B DDIT3 DLK1 FOXO1 HES1 LRP5 NCOR2 RUNX1T1 SHH SIRT1 SIRT2 TAZ TCF7L2 TSC22D3 VDR WNT1 WNT3A

Extracellular Molecules Extracellular Matrix (ECM) Structural Constituents:

COL3A1 ELN FN1

Reactive Oxygen Species (ROS) Activity:

AIFM1 CYBB GLUD1 NOX1 NOX4

Other Necrosis Genes:

CD40 FADD MGEA5 PARP1 PPIA RIPK1 RIPK3 SP1 TMEM123

Renin-Angiotensin System:

ACE ACE2 AGT AGTR1 ECE1 REN

Cytoskeleton Regulators:

ACTN1 ACTN2 ACTN3 ACTN4 ANAPC1 BAIAP2 CDC27 EXOC2 FARP2 FLNA FLNB LMO7 MAPRE1 MAPRE2 NME1 PARD3 SORBS1 SSX2IP TLN1 TLN2 VCL WAS WASF1 WASL ZYX

Carnitine Transferases:

CPT1A CPT1B CPT1C CPT2 CRAT CROT

Growth Factors and Receptors:

ANG ANGPT1 ANGPT2 ANPEP FGF1 FGF2 FIGF FLT1 JAG1 KDR NRP1 NRP2 PGF TYMP VEGFA VEGFB VEGFC

Adhesion Molecules Cell-matrix Adhesion:

CD44 ITGA2 ITGA5 ITGAX ITGB2 SPP1

Vasodilation:

ACE ACE2 ADM ADRB1 AGTR1 AGTR2 CALCA CPS1 EDNRB EPHX2 GCH1 KCNJ8 KNG1 NOS3 NPPB NPPC NPR1 P2RX4 PDE5A

Endocytosis:

DNM1 DNM2 HGS LMO7 PIK3CG PPAP2B SORBS1

Blood Coagulation and Circulation Circulation:

APOA1 APOB APOE COL3A1 ELN ENG LPA LPL NPY

Lipid Transport and Metabolism Steroid Metabolism:

NR1H3 PPARA PPARD PPARG RXRA

Vasotone:

AGTR1 DRD3 NOS3 NPPB NPPC REN

LDL Receptor Associated Proteins:

LRPAP1 PCSK9 SNX17

Cell Growth and Proliferation Negative Regulation of Cell Proliferation:

BCL2 FABP3 IL1A

Smooth Muscle Relaxation:

GUCY1A3 KCNMA1 P2RX4

Adhesion Molecules:

BAI1 COL4A3 IL8 NRP1 NRP2

Fatty Acid Transport:

CPT1A CPT1B CPT1C CPT2 CRAT CROT FABP1 FABP2 FABP3 FABP4 FABP5 FABP6 FABP7 SLC27A1 SLC27A2 SLC27A3 SLC27A4 SLC27A5 SLC27A6

Triacylglycerol Metabolism:

GK GK2 GPD1 GPD2 LIPE LPL

G-Protein Signaling:

ARF6 CDC42 DOCK4 FARP2 IQGAP1 MLLT4 RAC1 RALA RHOA

Apoptosis Anti-apoptosis:

BCL2 BCL2A1 BCL2L1 BIRC3 CCL2 CFLAR FAS IL1A IL2 NFKB1 SERPINB2 SPP1 TGFB1 TNF TNFAIP3

HDL Associated Proteins:

APOA1 APOD APOF APOL2 APOL5

Extracellular Molecules ECM Protease Inhibitors:

LPA SERPINB2 SERPINE1

RIPK3 Interactors:

GLUD1 GLUL PYGL RIPK1

Anorectic Genes Neuropeptides and Receptors:

ATRN BDNF BRS3 CALCA CALCR CARTPT CNTFR CRHR1 DRD1 DRD2 GH1 GH2 GHR GRP GRPR HRH1 HTR2C IL1A IL1B IL1R1 IL6 IL6R MC3R NMB NMBR NMU NMUR1 NTRK2 NTS NTSR1 POMC PRLHR SORT1 TRH UCN ZFP91

Oxidative Stress Responsive Genes:

APOE ATOX1 CAT CCL5 CYGB DHCR24 DUOX1 DUOX2 DUSP1 EPX FOXM1 FTH1 GCLC GCLM GPX1 GPX2 GPX3 GPX4 GPX5 GSR GSS HMOX1 HSPA1A KRT1 LPO MBL2 MPO MSRA NQO1 NUDT1 PDLIM1 PRDX2 PRDX5 PRDX6 PRNP RNF7 VIMP SEPP1 SIRT2 SOD1 SOD2 SQSTM1 SRXN1 TPO TTN TXN TXNRD1 TXNRD2

Lipid Transport and Metabolism Other Genes Related to Lipid Metabolism:

APOE LPA PLIN2

Adhesion Molecules Cell-cell Adhesion:

CD44 CDH5 ICAM1 ITGB2 SELE SELL TNF VCAM1 VEGFA

Acetyl-CoA Transferases:

ACAA1 ACAA2 ACAT1 ACAT2

Other Cytokines:

AIMP1 BMP2 CD40LG CSF1 CSF2 CSF3 FASLG IFNA2 IFNG LTA LTB MIF NAMPT OSM SPP1 TNF TNFSF10 TNFSF11 TNFSF13 TNFSF13B TNFSF4 VEGFA

Junction Associated Proteins:

AJAP1 CTNND1 DLG5 MLLT4 P2RX6 PARD3 PERP TJP1 VEZT

Orexigenic Genes Neuropeptides and Receptors:

ADRA2B AGRP CNR1 GAL GALR1 HCRT HCRTR1 MCHR1 NPY NPY1R NR3C1 OPRK1 OPRM1

LDL Associated Proteins:

ANKRA2 APOA4 APOC3 CDH13 COLEC12 SCARF1 SORL1

PARP1 Interactors:

CAPN1 CAPN2 CAPN3 CAPN5 CAPN6 CAPN7 CAPNS1 PPID

Myosin Light Chain Kinases:

MYLK MYLK2 MYLK3

Other Genes Involved in Superoxide Metabolism:

ALOX12 CCS DUOX1 DUOX2 MT3 NCF1 NCF2 NOS2 NOX4 NOX5 UCP2

Proteases, inhibitors and Other Matrix Proteins:

ANGPTL4 F3 PECAM1 PF4 PROK2 SERPINE1 SERPINF1

Required for TNF-Induced Apoptosis:

ATP6V1G2 CYLD SPATA2 SYCP2

Osmotic Shock:

AGT AVP AVPR1B BDKRB2 KCNMA1

Smooth Muscle Contraction:

ACTA2 ADRA1B ADRB1 BDKRB2 CACNA1C CAV1 EDN1 EDN2 EDNRA EDNRB KCNMA1 KNG1 P2RX4 PTGS1 PTGS2 UTS2

Pro-Apoptosis:

AIFM1 BAX BID BMF BNIP3L CASP8AP2 FADD FAF1 FAS FASLG FEM1B IKBKG PIDD MADD NGFR NGFRAP1 RIPK1 RIPK2 RIPK3 TNF TNFRSF10A TNFRSF25 TNFRSF8 TNFSF10 TRADD TRAF2

Adipogenesis Regulation Anti-Brown Adipose Tissue:

NCOA2 NR0B2 NR1H3 RB1 TWIST1 WNT10B

Vasoconstriction:

ACE ACE2 ADM ADRA1B AGT AGTR1 ALOX5 AVP AVPR1A BDKRB2 BMPR2 CACNA1C CAV1 ECE1 EDN1 EDN2 EDNRA EDNRB NPPC NPY1R PTGS1 PTGS2 UTS2R

Superoxide Dismutases (SOD):

SOD1 SOD2 SOD3

Death Receptor Signaling:

BID BIRC3 CASP8AP2 CYLD EDA2R FADD FAF1 FEM1B IKBKG PIDD MADD MYD88 NGF NGFR NGFRAP1 PARP1 RIPK1 TNFRSF14 TNFRSF17 TNFRSF1B TNFRSF25 TNFRSF4 TNFRSF8 TNFSF15 TRADD TRAF2

Genes Related to Energy Expenditure CNS-Derived Peptides and Receptors:

ADCYAP1 ADCYAP1R1 CPD CPE SIGMAR1 THRB

Regulatory Genes Adipokines:

ADIG ADIPOQ CFD LEP RETN

Nectins:

PVRL1 PVRL2 PVRL3 PVRL4

Adhesion Molecules Other Genes Involved in Adhesion:

CCL2 CCL5 CCR1 CTGF ELN ENG FN1 LAMA1 SELPLG THBS4 TNC VWF

Cell Growth and Proliferation Positive Regulation of Cell Proliferation:

CSF1 FGA FGF2 HBEGF IL2 IL3 IL5 LIF VEGFA

Acyl-CoA Thioesterases:

ACOT1 ACOT12 ACOT6 ACOT7 ACOT8 ACOT9

Transcription Regulators Other Transcription Regulators:

EGR1 KLF2 NFKB1 TNF TNFAIP3

Ketogenesis & Ketone Body Metabolism:

BDH1 BDH2 HMGCL HMGCS1 HMGCS2 OXCT2

Response to Virus:

CCL5 IFNAR2 TNF

Adipogenesis Regulation Pro-Brown Adipose Tissue:

BMP7 CREB1 DIO2 FOXC2 INSR IRS1 MAPK14 NRF1 PPARA PPARD PPARGC1A PPARGC1B PRDM16 SIRT3 SRC UCP1 WNT5A

RIPK1 Interactors:

FUS NFKB1 RIPK2 RIPK3

Desmosomes:

CDSN DSP JUP PKP1 PKP2 PKP3 PKP4 PNN PPL

Transcription Regulators Nuclear Receptors:

NR1H3 PPARA PPARD PPARG RXRA

Response to Oxidative Stress:

APOE CCL5 SOD1

Blood Coagulation and Circulation Regulation of Blood Pressure:

ACE FGA

Blood Pressure Regulation:

ACE ACE2 ACTA2 AGT AGTR2 AVP AVPR1A AVPR1B BDKRB2 CACNA1C CALCA DRD3 DRD5 ECE1 EDN1 EDN2 EDNRB EPHX2 GCH1 GUCY1A3 NOS3 NPPB NPPC NPR1 NPY1R P2RX4 PTGS1 PTGS2 REN UTS2 UTS2R

Cholesterol Transporters:

ABCA1 ABCG1 APOA1 APOE CETP STARD3

LDL Receptors:

CXCL16 LDLR LRP10 LRP12 LRP1B LRP6 OLR1 STAB1 STAB2 VLDLR

Other Genes Involved in ROS Metabolism:

AOX1 BNIP3 EPHX2 MPV17 SFTPD

Other Factors Involved in Angiogenesis Adhesion Molecules:

CCL11 CCL2 CDH5 COL18A1 CTGF ENG ERBB2 FN1 ITGAV ITGB3 S1PR1 THBS1 THBS2

Lipid Transport and Metabolism Fatty Acid Metabolism:

FABP3 LPL PPARA PTGS1

Acyl-CoA Synthetases:

ACSBG1 ACSBG2 ACSL1 ACSL3 ACSL4 ACSL5 ACSL6 ACSM3 ACSM4 ACSM5

Lipid Transport and Metabolism Lipoprotein Metabolism:

APOA1 APOE LDLR LPL

Response to Pests, Pathogens or Parasites:

CCL2 CCR2 CSF2 FN1 IL4 ITGB2 TNF

Protein Kinase Signaling:

CSNK2A1 CSNK2A2 CSNK2B DLG5

Cell Growth and Proliferation Other Genes Involved in Cell Growth and Proliferation:

CTGF ELN IFNG IL4 NPY

Degradation:

AGL PGM1 PGM2 PGM3 PYGL PYGM

Apoptosis Induction of Apoptosis:

APOE BAX BID CFLAR FAS

Notch Signaling:

DLL1 NOTCH1 NOTCH2 NOTCH3 NOTCH4

Anorectic Genes Gut Hormones and Receptors:

APOA4 CCK CCKAR GLP1R PYY

Other Genes Involved in Cholesterol Metabolism:

APOB APOF APOL1 APOL2 CELA3A CELA3B CYP11A1 CYP7B1 HDLBP IL4 INSIG1 INSIG2 LEP LIPE MBTPS1 NR0B2 NR1H4 OSBPL1A OSBPL5 PPARD SCAP SOAT1 SORL1 SREBF1 SREBF2 STARD3 VLDLR

Cholesterol Homeostasis:

ABCA1 ABCG1 ANGPTL3 APOA1 APOA2 APOA4 APOC3 APOE CETP LCAT LDLR LDLRAP1 PCSK9

Desmocollins & Desmogleins:

DSC1 DSC2 DSC3 DSG1 DSG2 DSG3 DSG4

Others:

ALDH2 DECR1 DECR2 ECHS1 ECI2 HADHA MCEE MUT PECR PPA1

Mitochondrial Genes:

AIFM1 BAX BID BNIP3L CYBB GLUD1 GLUL PPID RIPK1 SLC25A4

Anti-Apoptosis:

BIRC3 BNIP3L FAS MYD88 NFKB1 NGF NGFR RIPK1 RIPK2 TNF TNFRSF1A TNFRSF1B TNFRSF4 TRAF2

Cell Growth and Proliferation Regulation of the Cell Cycle:

FGF2 IL1A PDGFA PDGFB TGFB1 TGFB2 VEGFA

TCA Cycle:

ACLY ACO1 ACO2 CS DLAT DLD DLST FH IDH1 IDH2 IDH3A IDH3B IDH3G MDH1 MDH1B MDH2 OGDH PC PCK1 PCK2 PDHA1 PDHB SDHA SDHB SDHC SDHD SUCLA2 SUCLG1 SUCLG2

Blood Coagulation and Circulation Platelet Activation:

PDGFA PDGFB PDGFRB VWF

Catenins:

ARVCF CTNNA1 CTNNA2 CTNNA3 CTNNB1 CTNND1

Regulation of Necrosis:

FAS FASLG RIPK1 SLC25A4 TNF

Pathway Activity Signature Genes:

AKR1C2 BAG2 FHL2 GCLM GLA HMOX1 HSP90AA1 LHPP NCOA7 NQO1 PTGR1 SLC7A11 SPINK1 TRAPPC6A TXN TXNRD1

Cholesterol Efflux:

ABCA1 ABCG1 APOA1 APOA4 APOC3 APOE

Lipid Transport and Metabolism Lipid Transport:

ABCA1 APOA1 APOB APOE FABP3 LDLR LPA LPL MSR1

Pentose Phosphate Pathway:

G6PD H6PD PGLS PRPS1 PRPS1L1 PRPS2 RBKS RPE RPIA TALDO1 TKT

Regulatory Genes Enzymes:

LIPE LPL

Antioxidants Other Peroxidases:

CAT CYBB CYGB DUOX1 DUOX2 EPX LPO MPO PTGS1 PTGS2 TPO TTN

Other Factors Involved in Angiogenesis Growth Factors and Receptors:

CTGF EFNA1 EFNB2 EGF EPHB4 FGFR3 HGF IGF1 ITGB3 PDGFA S1PR1 TEK TGFA TGFB1 TGFB2 TGFBR1

Anorectic Genes Adipocyte-derived Peptides and Receptors:

LEP LEPR TNF

Acyl-CoA Oxidases:

ACOX1 ACOX2 ACOX3

Death Domain Receptors:

FAS TNFRSF10A TNFRSF1A

Adipogenesis Regulation Anti-White Adipose Tissue:

GATA2 GATA3 KLF2 KLF3

Lipid Transport and Metabolism Cholesterol Metabolism:

ABCA1 APOA1 APOB APOE IL4 LDLR

Interleukin Receptors:

IL10RA IL10RB IL1R1 IL5RA IL9R

Apoptosis Other Genes Related to Apoptosis:

IL5 ITGB2

Cholesterol Absorption:

CEL LDLR NPC1L1

Regulation:

PDK1 PDK2 PDK3 PDK4 PDP2 PDPR GSK3A GSK3B PHKA1 PHKB PHKG1 PHKG2

Adipogenesis Regulation Pro-White Adipose Tissue:

BMP2 BMP4 CEBPA EGR2 FGF10 KLF15 KLF4 SREBF1

Oxygen Transporters:

CYGB MB

Genes Related to Energy Expenditure Adipocyte-Derived Peptides and Receptors:

ADIPOQ ADIPOR1 ADIPOR2 ADRB1 C3 PPARA PPARG PPARGC1A PTPN1 UCP1

Interleukins:

IL13 IL15 IL16 IL17A IL17C IL17F IL1A IL1B IL1RN IL21 IL27 IL3 IL33 IL5 IL7 IL8 IL9

Hypoxia Response:

ACE ADM CAV1 ECE1 EDN1 EDNRA HIF1A KCNMA1 NOS3 NPPC PDE5A

Second-Messenger-Mediated Signaling:

ADRA1D PDE3B PTGIR S1PR1 SPHK1

Blood Coagulation and Circulation Blood Coagulation:

FGA ITGA2 LPA SERPINE1

Inflammatory Response:

CCL2 CCL5 CCR1 CCR2 IL1R1 IL1R2 ITGB2 NFKB1 NOS3 SELE SPP1 TNF

Gluconeogenesis:

FBP1 FBP2 G6PC G6PC3 PC PCK1 PCK2

Ion Transport:

ATP2C1 ATP6AP2 BDKRB1 CHRNA1 CHRNB1 CLIC1 CLIC4 CLIC5 CNGA1 CNGA2 CNGA3 CNGA4 CNGB1 CNGB3 ITPR1 ITPR2 PLCG2 SCNN1A SCNN1B SCNN1G SLC7A1

Other Genes Involved in Cholesterol Transport:

APOB LDLR NPC1L1 OSBPL5

Other Factors Involved in Angiogenesis Proteases, Inhibitors and Other Matrix Proteins:

LECT1 LEP MMP14 MMP2 MMP9 PLAU PLG TIMP1 TIMP2 TIMP3

Fatty Acid Biosynthesis Regulation:

FASN PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKACA PRKACB PRKAG1 PRKAG2 PRKAG3

Reverse Cholesterol Transport:

ABCA1 APOA1 APOA2 APOA4 APOC3 APOE CETP LCAT

Other Factors Involved in Angiogenesis Other Genes:

AKT1 HPSE ID1 NOTCH4 PTGS1 TIE1

Orexigenic Genes Gut Hormone and Receptor:

GHRL GHSR

Lipid Metabolism:

PDE3A PDE3B PLCG1 PLCG2 SPHK1 SPHK2

Cadherins:

CDH1 CDH2 CDH3 CDH4 CDH5

Other Factors Involved in Angiogenesis Cytokines:

CCL11 CCL2 CXCL1 CXCL10 CXCL5 CXCL6 CXCL9 EDN1 IFNA1 IFNG IL1B IL6 MDK TNF

Chemokine Receptors:

CCL13 CCR1 CCR2 CCR3 CCR4 CCR5 CCR6 CCR8 CX3CR1 CXCR1 CXCR2

Extracellular Molecules ECM Proteases:

ACE MMP1 MMP3

Regulatory Genes PPAR Gamma Targets:

ADIPOQ AGT CEBPA CFD FABP4 FASN IRS2 KLF15 LIPE LPL PPARG PPARGC1A RETN SIRT3 SLC2A4 SREBF1

Antioxidants Glutathione Peroxidases (GPx):

GPX1 GPX2 GPX3 GPX4 GPX5 GSTP1 GSTZ1

Nitric Oxide Metabolism:

AGTR2 ARG2 CAV1 CPS1 EDN1 GCH1 GCHFR HIF1A NOS3 P2RX4

Cholesterol Catabolism:

AKR1D1 APOE CEL CYP39A1 CYP46A1 CYP7A1 SCARF1 SNX17 TRERF1

Glycolysis:

ALDOA ALDOB ALDOC BPGM ENO1 ENO2 ENO3 GALM GCK GPI HK2 HK3 PFKL PGAM2 PGK1 PGK2 PGM1 PGM2 PGM3 PKLR TPI1

CADgene:

ABCA1 ABCB1 ABCC1 ABCC3 ABCC6 ABCG1 ABCG8 ABO ACAT1 ACAT2 ACE ACE2 ACP1 ACTA2 ACTC1 ACYP2 ADA ADAM17 ADAM33 ADAM8 ADAMTS1 ADAMTS13 ADD1 ADH1C ADIPOQ ADIPOR2 ADM ADORA3 ADRA2B ADRA2C ADRB1 ADRB2 ADRB3 ADRBK1 AGER AGT AGTR1 AGTR2 AHSG AKR1B1 AKT3 ALDH2 ALOX12 ALOX15 ALOX15B ALOX5 ALOX5AP ALPL AMPD1 ANGPTL4 ANXA2 ANXA5 AP1G2 APC APCS APLN APOA1 APOA2 APOA4 APOA5 APOB APOC1 APOC2 APOC3 APOC4 APOD APOE APOH APOM AQP5 AQP9 AR ARG1 ARG2 ARID5B ARL15 ARMS2 ATM ATP2A2 ATP2B1 ATP5J ATP6AP2 BAX BCAR1 BCL11B BCL2 BDKRB2 BDNF BHMT BNIP3 BRAP BRCA1 BRCA2 BTN2A1 BTNL2 C3 C3AR1 C4B C5 C6orf10 ADTRP CACNA1C CALCA CALCRL CAPN10 CASP1 CASP10 CASQ2 CASR CBS CCL11 CCL2 CCL22 CCL26 CCL5 CCR2 CCR5 CCR9 CD14 CD36 CD40 CD40LG CD44 CD93 CDH13 CDKN1A CDKN1C CDKN2A CDKN2B CELSR2 CETP CFH CGB CHGA CHI3L1 CHIT1 CHRM2 CHRNA5 CIITA CLEC16A CLOCK CLU CMA1 CNDP1 CNR1 COL1A1 COL1A2 COMT CP CPB2 CPE CR1 CREG1 CRP CSMD2 CST3 CTGF CTSS CX3CR1 CXCL10 CXCL12 CXCL16 CXCL5 CXCR1 CXCR2 CXCR4 CYBA CYP11B1 CYP11B2 CYP17A1 CYP19A1 CYP1A1 CYP1A2 CYP24A1 CYP26B1 CYP2C19 CYP2C8 CYP2C9 CYP2D6 CYP2E1 CYP2J2 CYP4A11 CYP4F2 CYP7A1 CYSLTR1 DDAH2 DDX58 DHX40 DIO2 DNASE1 DPP4 DRD1 ECE1 EDN1 EDNRA EFCAB11 EGFR EGR1 ELANE ENPP1 EPHA2 EPHX1 EPHX2 ERCC2 ESR1 ESR2 F12 F13A1 F2 F2R F2RL3 F3 F5 F7 F8 F9 FABP2 FABP3 FABP4 FADS1 FADS2 FAM5C FAS FCGR1A FCGR2A FGA FGB FGF2 FGF4 FGFR4 FGG FLAD1 FLT1 FN1 FOXO1 FOXP3 FTL FTO FUT2 FUT3 GADD45B GALNT4 GAS6 GATA2 GCH1 GCK GCKR GCLC GCLM GDF15 GHRL GHSR GJA4 GLIS1 GLO1 GNB3 GOSR2 GP1BA GP5 GP6 GPD1L GPR77 GPX1 GRIA1 GSK3B GSTA1 GSTM1 GSTP1 GSTT1 GUCY1A3 GYS1 HBA1 HDAC9 HFE HGF HIF1A HLA-B HMGB1 HMGCR HMOX1 HNF1A HNRNPUL1 HP HRG HSD11B1 HSF1 HSPA1A HSPA2 HSPA4 HSPB1 HSPB7 HSPD1 HTR2A ICAM1 IFNB1 IFNG IGF1 IGF1R IGFBP1 IGFBP3 IL10 IL12B IL16 IL17A IL17F IL18 IL1A IL1B IL1R1 IL1R2 IL1RN IL23A IL4 IL5 IL6 IL6R IL6ST IL8 ILF3 INSIG1 INSIG2 IRF5 IRS1 IRS2 ITGA2 ITGA2B ITGB3 ITIH3 ITPR3 KCNE1L KCNMA1 KCNQ1 KCTD1 KDR KIAA0391 KIAA1462 KIF6 KL KLF14 KLF2 KLF5 LAMA3 LAMP2 LBP LCAT LCT LDLR LEP LGALS2 LIAS LIPC LIPG LMNA LPA LPL LRP1 LRP6 LRP8 LRPAP1 LSAMP LTA LTA4H LTBP1 MAOA MAP1LC3A MBL2 MEF2A MFN2 MGP MIA3 MIF MKL1 MLXIPL MMP1 MMP12 MMP2 MMP3 MMP7 MMP8 MMP9 MPO MSRA MTAP MTHFD1L MTHFR MTR MTRR MTTP MYB NAMPT NES NFATC1 NFE2L2 NFKB1 NFKBIL1 NOD1 NOD2 NOS1 NOS1AP NOS2 NOS3 NPPA NPPB NPR1 NPR2 NPY NR1H3 NR1H4 NR3C1 NR3C2 NR4A2 NRG1 OAZ1 OLR1 OPCML OR13G1 P2RX7 P2RY12 P2RY2 PAFAH1B1 PAFAH1B3 PALLD PAPPA PARP1 PAWR PCDH15 PCSK2 PCSK5 PCSK9 PDCD1 PDE4D PDGFB PDGFD PDX1 PDXP PECAM1 PHACTR1 PLA2G10 PLA2G2A PLA2G7 PLAT PLAU PLAUR PLD3 PLG PLIN1 PLTP PON1 PON2 PON3 POSTN PPARA PPARD PPARG PPARGC1A PRKCH PRKG2 PROC PROCR PROS1 PRTN3 PSMA5 PSMA6 PTEN PTGER2 PTGIS PTGS2 PTPN22 PTPN9 PTX3 PVRL2 RAMP2 RAMP3 RBP4 REL REN RETN RGS2 RHOA ROS1 RPA1 RPL7 RYR3 S100A12 S100A8 S100A9 S100B SAA1 SCAP SCARB1 SCN5A SCNN1G SDC4 SDK1 SELE SELL SELP SELPLG VIMP SEMA3F SEMA4D SERPINA1 SERPINA12 SERPINB2 SERPINC1 SERPIND1 SERPINE1 SFTPD SGMS1 SGMS2 SH2B3 SHBG SHC1 SIRT1 SLC22A3 SLC2A9 SLC6A4 SLC8A1 SMTN SOAT1 SOD1 SOD2 SOD3 SORT1 SPP1 SRC SREBF1 SREBF2 STAT4 SULT1A1 SUMO4 TAS2R50 TBXA2R TBXAS1 TCN2 TDP1 TF TFPI TGFB1 TGFB2 THBD THBS1 THBS2 THBS4 TIMP1 TIMP2 TIMP3 TIMP4 TLR2 TLR4 TLR5 TLR9 TMEM121 TNC TNF TNFAIP3 TNFRSF11B TNFRSF1A TNFRSF1B TNFRSF4 TNFSF11 TNFSF4 TNNI3 TNNT2 TP53 TPO TRAF3IP2 TRAF6 TRIB1 TRPC4 TTC32 TXNIP TYMS UCN UCN2 UCP2 UGT1A1 USF1 UTS2 VAMP8 VCAM1 VDR VEGFA VKORC1 VLDLR VWF WARS WDR35 WNK1 WRN WWOX XRCC1 XRCC3 ZFHX3 ZNF202 ZNF259 ZNF385B ZNF627

Extracellular Molecules Other Extracellular Molecules:

PLIN2 APOA1 APOB APOE CCL2 CCL5 CSF2 CTGF FGA FGF2 HBEGF IFNAR2 IFNG IL1A IL2 IL3 IL4 IL5 LAMA1 LIF LPL NPY PDGFA PDGFB SPP1 THBS4 TNC VEGFA VWF

Other Cytokine Receptor:

TNFRSF11B

Cholesterol Biosynthesis:

ACAA2 CNBP CYB5R3 CYP51A1 DHCR24 DHCR7 FDFT1 FDPS HMGCR HMGCS1 HMGCS2 IDI1 IDI2 MVD MVK NPC1L1 NSDHL PMVK PRKAA1 PRKAA2 PRKAG2 TM7SF2

List of LncRNAs

The LncRNAs collected for the mouse cardiovascular diseases are listed in Table 1. Click an LncRNA accession number to see its detailed information and its potential target gene(s) in the cardiovascular diseases.

Table 1. Mouse cardiovascular disease LncRNAs

Dpf2, Pcdh15, Ccr5, Hipk2, Porcn, Grn, Bcl11a, Dcc, Ucp2, Ptk2b, Grn, Mapk7, Rere, Cdh4, Prkcd, Klhl12, Limk1, Cngb1, Baz2b, Chd3, Zfp385b, Fgf2, Myh10, Phc2, Top2a, Ttc23, Itpr2, Mapre3, Pcdh15, Med12, Adam17, Mob1b, Stk36, Rad18, Taok2, Pcdh15, Crot, Tkt, Adrbk1, Acin1, Ttc21b, Kdm2b, Pou6f2, Fbxo31, Ppfia1, Nedd4, Ager, Nos1ap, Nudt13, Ciita, Park2

Full List of Mouse Cardiovascular Disease Related LncRNAs.pdf

Gene List

The potential gene targets of mouse cardiovascular disease focused LncRNAs are listed in Table 2. Click the protein gene names to see the detailed information about the genes and their corresponding regulatory LncRNAs in the cardiovascular diseases.

Table 2. Functional gene grouping

Regulatory Genes Hormones:

Agt Angpt2

Cell Growth and Proliferation Growth Factors and Receptors:

Csf2 Kdr Pdgfrb Spp1

Other Genes Related to Stress Response:

Ifng Pparg Vegfa

Other Genes:

Hif1a Nos3 Sphk1

Antioxidants Other Antioxidants:

Alb Apoe Gsr Mt3 Vimp Sod1 Sod3 Srxn1 Txnrd1 Txnrd2

Response to Wounding:

Ccr1 Ccr2 Ctgf Fn1 Pdgfb Tnf Vwf

Synthesis:

Gbe1 Gys1 Gys2 Ugp2

Adipogenesis Regulation Pro-Adipogenesis:

Acacb Axin1 Ccnd1 Cdk4 Cebpb Cebpd Dkk1 E2f1 Fabp4 Fasn Fgf1 Fgf2 Irs2 Jun Lmna Lpl Pparg Rxra Sfrp1 Sfrp5 Slc2a4 Wnt5b

Anorectic Genes Pancreas Derived Peptides and Receptors:

Calcr Clps Gcg Gcgr Glp1r Iapp Ins2 Insr Ramp3 Sst Sstr2

Cyclic-GMP Synthesis & Signaling:

Adra1d Gucy1b3 Pde3b Prkg1 Prkg2 Ptgir S1pr1

Ubiquitin Ligases:

Anapc1 Cbll1

Required for TNF-Induced Necrosis:

Atp6v1g2 Bmf 9430015G10Rik Ccdc103 Commd4 Cyld Dennd4a Dpysl4 Eif5b Foxi1 Galnt5 Grb2 Hspbap1 Jph3 Kcnip1 Mag Olfr1404 Parp2 Rab25 Spata2 Sycp2 Tmem57 Txnl4b

Chemokines:

Hc Ccl1 Ccl11 Ccl2 Ccl17 Ccl12 Ccl20 Ccl22 Ccl24 Ccl4 Ccl5 Ccl7 Cx3cl1 Cxcl3 Cxcl10 Cxcl13 Cxcl1 Cxcl2 Cxcl5 Cxcl9

"Other Factors Involved in Angiogenesis Proteases, Inhibitors and Other Matrix Proteins":

Lect1 Lep Mmp14 Mmp2 Mmp9 Plau Plg Timp1 Timp2 Timp3

Nitric Oxide Signaling:

Agt Agtr2 Gucy1a3 Gucy1b3 Nosip Nostrin

Antioxidants Peroxiredoxins (TPx):

Prdx1 Prdx2 Prdx3 Prdx4 Prdx5 Prdx6

Adipogenesis Regulation Anti-Adipogenesis:

Adrb2 Cdkn1a Cdkn1b Ddit3 Dlk1 Foxo1 Hes1 Lrp5 Ncor2 Runx1t1 Shh Sirt1 Sirt2 Taz Tcf7l2 Tsc22d3 Vdr Wnt1 Wnt3a

Extracellular Molecules Extracellular Matrix (ECM) Structural Constituents:

Col3a1 Eln Fn1

Reactive Oxygen Species (ROS) Activity:

Aifm1 Cybb Glud1 Nox1 Nox4

Other Necrosis Genes:

Cd40 Fadd Mgea5 Parp1 Ppia Ripk1 Ripk3 Sp1 Tmem123

Renin-Angiotensin System:

Ace Ace2 Agt Agtr1a Ece1 Ren1

Cytoskeleton Regulators:

Actn1 Actn2 Actn4 Anapc1 Baiap2 Cdc27 Exoc2 Farp2 Flna Flnb Lmo7 Mapre1 Mapre2 Nme1 Pard3 Sorbs1 Ssx2ip Tln1 Tln2 Vcl Was Wasf1 Wasl Zyx

Carnitine Transferases:

Cpt1a Cpt1b Cpt1c Cpt2 Crat Crot

Growth Factors and Receptors:

Ang Angpt1 Angpt2 Anpep Fgf1 Fgf2 Figf Flt1 Jag1 Kdr Nrp1 Nrp2 Pgf Tymp Vegfa Vegfc

Adhesion Molecules Cell-matrix Adhesion:

Cd44 Itga2 Itga5 Itgax Itgb2 Spp1

Vasodilation:

Ace Ace2 Adm Adrb1 Agtr1a Agtr2 Calca Cps1 Ednrb Ephx2 Gch1 Kcnj8 Kng1 Kng2 Nos3 Nppc Npr1 P2rx4 Pde5a

Endocytosis:

Dnm1 Dnm2 Hgs Lmo7 Pik3cg Ppap2b Sorbs1

Blood Coagulation and Circulation Circulation:

Apoa1 Apob Apoe Col3a1 Eln Eng Lpl Npy

Lipid Transport and Metabolism Steroid Metabolism:

Nr1h3 Ppara Ppard Pparg Rxra

"Response to Pests, Pathogens or Parasites":

Ccl12 Ccr2 Csf2 Fn1 Il4 Itgb2 Tnf

Vasotone:

Agtr1a Drd3 Nos3 Nppc Ren1

LDL Receptor Associated Proteins:

Lrpap1 Pcsk9 Snx17

Cell Growth and Proliferation Negative Regulation of Cell Proliferation:

Bcl2 Fabp3 Il1a

Smooth Muscle Relaxation:

Gucy1a3 Kcnma1 P2rx4

Adhesion Molecules:

Bai1 Col4a3 Nrp1 Nrp2

Fatty Acid Transport:

Cpt1a Cpt1b Cpt1c Cpt2 Crat Crot Fabp1 Fabp2 Fabp3 Fabp4 Fabp5 Fabp6 Fabp7 Slc27a1 Slc27a2 Slc27a3 Slc27a4 Slc27a5 Slc27a6

Triacylglycerol Metabolism:

Gyk Gykl1 Gpd1 Gpd2 Lipe Lpl

G-Protein Signaling:

Arf6 Cdc42 Dock4 Farp2 Iqgap1 Mllt4 Rac1 Rala Rhoa

Apoptosis Anti-apoptosis:

Bcl2 Bcl2a1a Bcl2a1b Bcl2a1d Bcl2l1 Birc3 Ccl12 Cflar Fas Il1a Il2 Nfkb1 Serpinb2 Spp1 Tgfb1 Tnf Tnfaip3

HDL Associated Proteins:

Apoa1 Apod Apof Apol8

Extracellular Molecules ECM Protease Inhibitors:

Serpinb2 Serpine1

RIPK3 Interactors:

Glud1 Glul Pygl Ripk1

Oxidative Stress Responsive Genes:

Apoe Atox1 Cat Ccl5 Cygb Dhcr24 Duox1 Duox2 Dusp1 Epx Foxm1 Fth1 Gclc Gclm Gpx1 Gpx2 Gpx3 Gpx4 Gpx5 Gsr Gss Hmox1 Hspa1a Hspa1b Krt1 Lpo Mbl2 Mpo Msra Nqo1 Nudt1 Pdlim1 Prdx2 Prdx5 Prdx6 Prnp Rnf7 Vimp Sepp1 Sirt2 Sod1 Sod2 Sqstm1 Srxn1 Tpo Ttn Txn1 Txnrd1 Txnrd2

"Proteases, inhibitors and Other Matrix Proteins":

Angptl4 F3 Pecam1 Pf4 Prok2 Serpine1 Serpinf1

Lipid Transport and Metabolism Other Genes Related to Lipid Metabolism:

Apoe Plin2

Adhesion Molecules Cell-cell Adhesion:

Cd44 Cdh5 Icam1 Itgb2 Sele Sell Tnf Vcam1 Vegfa

Acetyl-CoA Transferases:

Acaa1a Acaa2 Acat1

Other Cytokines:

Aimp1 Bmp2 Cd40lg Csf1 Csf2 Csf3 Fasl Ifng Lta Ltb Mif Nampt Osm Spp1 Tnf Tnfsf10 Tnfsf11 Tnfsf13 Tnfsf13b Tnfsf4 Vegfa

Junction Associated Proteins:

Ajap1 Ctnnd1 Dlg5 Mllt4 P2rx6 Pard3 Perp Tjp1 Vezt

Orexigenic Genes Neuropeptides and Receptors:

Adra2b Agrp Cnr1 Gal Galr1 Hcrt Hcrtr1 Mchr1 Npy Npy1r Nr3c1 Oprk1 Oprm1

LDL Associated Proteins:

Ankra2 Apoa4 Apoc3 Cdh13 Colec12 Scarf1 Sorl1

PARP1 Interactors:

Capn1 Capn2 Capn3 Capn5 Capn6 Capn7 Capns1 Ppid

Myosin Light Chain Kinases:

Mylk Mylk2 Mylk3

Other Genes Involved in Superoxide Metabolism:

Alox12 Ccs Duox1 Duox2 Mt3 Ncf1 Ncf2 Nos2 Nox4 Ucp2

Required for TNF-Induced Apoptosis:

Atp6v1g2 Cyld Spata2 Sycp2

Osmotic Shock:

Agt Avp Avpr1b Bdkrb2 Kcnma1

Smooth Muscle Contraction:

Acta2 Adra1b Adrb1 Bdkrb2 Cacna1c Cav1 Edn1 Edn2 Ednra Ednrb Kcnma1 Kng1 Kng2 P2rx4 Ptgs1 Ptgs2 Uts2

Pro-Apoptosis:

Aifm1 Bax Bid Bmf Bnip3l Casp8ap2 Fadd Faf1 Fas Fasl Fem1b Ikbkg Lrdd Madd Ngfr Ngfrap1 Ripk1 Ripk2 Ripk3 Tnf Tnfrsf10b Tnfrsf25 Tnfrsf8 Tnfsf10 Tradd Traf2

Adipogenesis Regulation Anti-Brown Adipose Tissue:

Ncoa2 Nr0b2 Nr1h3 Rb1 Twist1 Wnt10b

Vasoconstriction:

Ace Ace2 Adm Adra1b Agt Agtr1a Alox5 Avp Avpr1a Bdkrb2 Bmpr2 Cacna1c Cav1 Ece1 Edn1 Edn2 Ednra Ednrb Nppc Npy1r Ptgs1 Ptgs2 Uts2r

Superoxide Dismutases (SOD):

Sod1 Sod2 Sod3

Death Receptor Signaling:

Bid Birc3 Casp8ap2 Cyld Eda2r Fadd Faf1 Fem1b Ikbkg Lrdd Madd Myd88 Ngf Ngfr Ngfrap1 Parp1 Ripk1 Tnfrsf14 Tnfrsf17 Tnfrsf1b Tnfrsf25 Tnfrsf4 Tnfrsf8 Tnfsf15 Tradd Traf2

Genes Related to Energy Expenditure CNS-Derived Peptides and Receptors:

Adcyap1 Adcyap1r1 Cpd Cpe Sigmar1 Thrb

Regulatory Genes Adipokines:

Adig Adipoq Cfd Lep Retn

Nectins:

Pvrl1 Pvrl2 Pvrl3 Pvrl4

Adhesion Molecules Other Genes Involved in Adhesion:

Ccl12 Ccl5 Ccr1 Ctgf Eln Eng Fn1 Lama1 Selplg Thbs4 Tnc Vwf

Cell Growth and Proliferation Positive Regulation of Cell Proliferation:

Csf1 Fga Fgf2 Hbegf Il2 Il5 Lif Vegfa

Acyl-CoA Thioesterases:

Acot3 Acot12 Acot7 Acot8

Transcription Regulators Other Transcription Regulators:

Egr1 Klf2 Nfkb1 Tnf Tnfaip3

Ketogenesis & Ketone Body Metabolism:

Bdh1 Bdh2 Hmgcl Hmgcs1 Hmgcs2 Oxct2a Oxct2b

Response to Virus:

Ccl5 Ifnar2 Tnf

Adipogenesis Regulation Pro-Brown Adipose Tissue:

Bmp7 Creb1 Dio2 Foxc2 Insr Irs1 Mapk14 Nrf1 Ppara Ppard Ppargc1a Ppargc1b Prdm16 Sirt3 Src Ucp1 Wnt5a

RIPK1 Interactors:

Fus Nfkb1 Ripk2 Ripk3

Desmosomes:

Cdsn Dsp Jup Pkp1 Pkp2 Pkp3 Pkp4 Pnn Ppl

Transcription Regulators Nuclear Receptors:

Nr1h3 Ppara Ppard Pparg Rxra

Response to Oxidative Stress:

Apoe Ccl5 Sod1

Blood Coagulation and Circulation Regulation of Blood Pressure:

Ace Fga

Blood Pressure Regulation:

Ace Ace2 Acta2 Agt Agtr2 Avp Avpr1a Avpr1b Bdkrb2 Cacna1c Calca Drd3 Drd5 Ece1 Edn1 Edn2 Ednrb Ephx2 Gch1 Gucy1a3 Nos3 Nppc Npr1 Npy1r P2rx4 Ptgs1 Ptgs2 Ren1 Uts2 Uts2r

Cholesterol Transporters:

Abca1 Abcg1 Apoa1 Apoe Stard3

LDL Receptors:

Cxcl16 Ldlr Lrp10 Lrp12 Lrp1b Lrp6 Olr1 Stab1 Stab2 Vldlr

Other Genes Involved in ROS Metabolism:

Aox1 Bnip3 Ephx2 Mpv17 Sftpd

Other Factors Involved in Angiogenesis Adhesion Molecules:

Ccl11 Ccl12 Cdh5 Col18a1 Ctgf Eng Erbb2 Fn1 Itgav Itgb3 S1pr1 Thbs1 Thbs2

Lipid Transport and Metabolism Fatty Acid Metabolism:

Fabp3 Lpl Ppara Ptgs1

Acyl-CoA Dehydrogenases:

Acad10 Acad11 Acad9 Acadl Acadm Acads Acadsb Acadvl Ehhadh Gcdh

Acyl-CoA Synthetases:

Acsbg1 Acsbg2 Acsl1 Acsl3 Acsl4 Acsl5 Acsl6 Acsm3 Acsm4 Acsm5

Lipid Transport and Metabolism Lipoprotein Metabolism:

Apoa1 Apoe Ldlr Lpl

Anorectic Genes Neuropeptides and Receptors:

Atrn Bdnf Brs3 Calca Calcr Cartpt Cntfr Crhr1 Drd1a Drd2 Ghr Grp Grpr Hrh1 Htr2c Il1a Il1b Il1r1 Il6 Il6ra Mc3r Nmb Nmbr Nmu Nmur1 Ntrk2 Nts Ntsr1 Pomc Prlhr Sort1 Trh Ucn Zfp91

Protein Kinase Signaling:

Csnk2a1 Csnk2a2 Csnk2b Dlg5

Cell Growth and Proliferation Other Genes Involved in Cell Growth and Proliferation:

Ctgf Eln Ifng Il4 Npy

Degradation:

Agl Pgm2 Pgm1 Pgm3 Pygl Pygm

Apoptosis Induction of Apoptosis:

Apoe Bax Bid Cflar Fas

Notch Signaling:

Dll1 Notch1 Notch2 Notch3 Notch4

Anorectic Genes Gut Hormones and Receptors:

Apoa4 Cck Cckar Glp1r Pyy

Other Genes Involved in Cholesterol Metabolism:

Apob Apof Apol8 Gm13011 Cela3b Cyp11a1 Cyp7b1 Hdlbp Il4 Insig1 Insig2 Lep Lipe Mbtps1 Nr0b2 Nr1h4 Osbpl1a Osbpl5 Ppard Scap Soat1 Sorl1 Srebf1 Srebf2 Stard3 Vldlr

Cholesterol Homeostasis:

Abca1 Abcg1 Angptl3 Apoa1 Apoa2 Apoa4 Apoc3 Apoe Lcat Ldlr Ldlrap1 Pcsk9

Desmocollins & Desmogleins:

Dsc1 Dsc2 Dsc3 Dsg1a Dsg1b Dsg2 Dsg3 Dsg4

Others:

Aldh2 Decr1 Decr2 Echs1 Eci2 Hadha Mcee Mut Pecr Ppa1

Mitochondrial Genes:

Aifm1 Bax Bid Bnip3l Cybb Glud1 Glul Ppid Ripk1 Slc25a4

Anti-Apoptosis:

Birc3 Bnip3l Fas Myd88 Nfkb1 Ngf Ngfr Ripk1 Ripk2 Tnf Tnfrsf1a Tnfrsf1b Tnfrsf4 Traf2

Cell Growth and Proliferation Regulation of the Cell Cycle:

Fgf2 Il1a Pdgfa Pdgfb Tgfb1 Tgfb2 Vegfa

TCA Cycle:

Acly Aco1 Aco2 Cs Dlat Dld Dlst Fh1 Idh1 Idh2 Idh3a Idh3b Idh3g Mdh1 Mdh1b Mdh2 Ogdh Pcx Pck1 Pck2 Pdha1 Pdhb Sdha Sdhb Sdhc Sdhd Sucla2 Suclg1 Suclg2

Blood Coagulation and Circulation Platelet Activation:

Pdgfa Pdgfb Pdgfrb Vwf

Catenins:

Arvcf Ctnna1 Ctnna2 Ctnna3 Ctnnb1 Ctnnd1

Regulation of Necrosis:

Fas Fasl Ripk1 Slc25a4 Tnf

Pathway Activity Signature Genes:

Akr1c21 Bag2 Fhl2 Gclm Gla Hmox1 Hsp90aa1 Lhpp Ncoa7 Nqo1 Ptgr1 Slc7a11 Spink3 Trappc6a Txn1 Txnrd1

Cholesterol Efflux:

Abca1 Abcg1 Apoa1 Apoa4 Apoc3 Apoe

Lipid Transport and Metabolism Lipid Transport:

Abca1 Apoa1 Apob Apoe Fabp3 Ldlr Lpl Msr1

Pentose Phosphate Pathway:

G6pdx H6pd Pgls Prps1 Prps1l1 Prps2 Rbks Rpe Rpia Taldo1 Tkt

Regulatory Genes Enzymes:

Lipe Lpl

Antioxidants Other Peroxidases:

Cat Cybb Cygb Duox1 Duox2 Epx Lpo Mpo Ptgs1 Ptgs2 Tpo Ttn

Other Factors Involved in Angiogenesis Growth Factors and Receptors:

Ctgf Efna1 Efnb2 Egf Ephb4 Fgfr3 Hgf Igf1 Itgb3 Pdgfa S1pr1 Tek Tgfa Tgfb1 Tgfb2 Tgfbr1

Anorectic Genes Adipocyte-derived Peptides and Receptors:

Lep Lepr Tnf

Acyl-CoA Oxidases:

Acox1 Acox2 Acox3

Death Domain Receptors:

Fas Tnfrsf10b Tnfrsf1a

Adipogenesis Regulation Anti-White Adipose Tissue:

Gata2 Gata3 Klf2 Klf3

Lipid Transport and Metabolism Cholesterol Metabolism:

Abca1 Apoa1 Apob Apoe Il4 Ldlr

Interleukin Receptors:

Il10ra Il10rb Il1r1 Il5ra Il9r

Apoptosis Other Genes Related to Apoptosis:

Il5 Itgb2

Cholesterol Absorption:

Cel Ldlr Npc1l1

Regulation:

Pdk1 Pdk2 Pdk3 Pdk4 Pdp2 Pdpr Gsk3a Gsk3b Phka1 Phkb Phkg1 Phkg2

Adipogenesis Regulation Pro-White Adipose Tissue:

Bmp2 Bmp4 Cebpa Egr2 Fgf10 Klf15 Klf4 Srebf1

Oxygen Transporters:

Cygb Mb

Genes Related to Energy Expenditure Adipocyte-Derived Peptides and Receptors:

Adipoq Adipor1 Adipor2 Adrb1 C3 Ppara Pparg Ppargc1a Ptpn1 Ucp1

Interleukins:

Il13 Il15 Il16 Il17a Il17c Il17f Il1a Il1b Il1rn Il21 Il27 Il33 Il5 Il7 Il9

Hypoxia Response:

Ace Adm Cav1 Ece1 Edn1 Ednra Hif1a Kcnma1 Nos3 Nppc Pde5a

Second-Messenger-Mediated Signaling:

Adra1d Pde3b Ptgir S1pr1 Sphk1

Blood Coagulation and Circulation Blood Coagulation:

Fga Itga2 Serpine1

Inflammatory Response:

Ccl12 Ccl5 Ccr1 Ccr2 Il1r1 Il1r2 Itgb2 Nfkb1 Nos3 Sele Spp1 Tnf

Gluconeogenesis:

Fbp1 Fbp2 G6pc G6pc3 Pcx Pck1 Pck2

Ion Transport:

Atp2c1 Atp6ap2 Bdkrb1 Chrna1 Chrnb1 Clic1 Clic4 Clic5 Cnga1 Cnga2 Cnga3 Cnga4 Cngb1 Cngb3 Itpr1 Itpr2 Plcg2 Scnn1a Scnn1b Scnn1g Slc7a1

Other Genes Involved in Cholesterol Transport:

Apob Ldlr Npc1l1 Osbpl5

Fatty Acid Biosynthesis Regulation:

Fasn Prkaa1 Prkaa2 Prkab1 Prkab2 Prkaca Prkacb Prkag1 Prkag2 Prkag3

Reverse Cholesterol Transport:

Abca1 Apoa1 Apoa2 Apoa4 Apoc3 Apoe Lcat

Other Factors Involved in Angiogenesis Other Genes:

Akt1 Hpse Id1 Notch4 Ptgs1 Tie1

Orexigenic Genes Gut Hormone and Receptor:

Ghrl Ghsr

Lipid Metabolism:

Pde3a Pde3b Plcg1 Plcg2 Sphk1 Sphk2

Cadherins:

Cdh1 Cdh2 Cdh3 Cdh4 Cdh5

Other Factors Involved in Angiogenesis Cytokines:

Ccl11 Ccl12 Cxcl3 Cxcl10 Cxcl5 Cxcl9 Edn1 Gm12597 Gm13280 Ifna1 Ifna11 Ifna12 Ifna13 Ifna14 Ifna2 Ifna5 Ifna6 Ifna7 Ifna9 Ifnab Ifng Il1b Il6 Mdk Tnf

Chemokine Receptors:

Ccl2 Ccr1 Ccr2 Ccr3 Ccr4 Ccr5 Ccr6 Ccr8 Cx3cr1 Cxcr1 Cxcr2

Extracellular Molecules ECM Proteases:

Ace Mmp1a Mmp3

Regulatory Genes PPAR Gamma Targets:

Adipoq Agt Cebpa Cfd Fabp4 Fasn Irs2 Klf15 Lipe Lpl Pparg Ppargc1a Retn Sirt3 Slc2a4 Srebf1

Antioxidants Glutathione Peroxidases (GPx):

Gpx1 Gpx2 Gpx3 Gpx4 Gpx5 Gstp1 Gstp2 Gstz1

Nitric Oxide Metabolism:

Agtr2 Arg2 Cav1 Cps1 Edn1 Gch1 Gchfr Hif1a Nos3 P2rx4

Cholesterol Catabolism:

Akr1d1 Apoe Cel Cyp39a1 Cyp46a1 Cyp7a1 Scarf1 Snx17 Trerf1

Glycolysis:

Aldoa Aldob Aldoc Bpgm Eno1 Gm5506 Eno2 Eno3 Galm Gck Gpi1 Hk2 Hk3 Pfkl Pgam2 Pgk1 Pgk2 Pgm2 Pgm1 Pgm3 Pklr Tpi1

CADgene:

Abca1 Abcb1a Abcc1 Abcc3 Abcc6 Abcg1 Abcg8 Abo Acat1 Ace Ace2 Acp1 Acta2 Actc1 Acyp2 Ada Adam17 Adam33 Adam8 Adamts1 Adamts13 Add1 Adh1 Adipoq Adipor2 Adm Adora3 Adra2b Adra2c Adrb1 Adrb2 Adrb3 Adrbk1 Ager Agt Agtr1a Agtr2 Ahsg Akr1b3 Akt3 Aldh2 Alox12 Alox15 Alox8 Alox5 Alox5ap Alpl Ampd1 Angptl4 Anxa2 Anxa5 Ap1g2 Apc Apcs Apln Apoa1 Apoa2 Apoa4 Apoa5 Apob Apoc1 Apoc2 Apoc3 Apoc4 Apod Apoe Apoh Apom Aqp5 Aqp9 Ar Arg1 Arg2 Arid5b Arl15 Atm Atp2a2 Atp2b1 Atp5j Atp6ap2 Bax Bcar1 Bcl11b Bcl2 Bdkrb2 Bdnf Bhmt Bnip3 Brap Brca1 Brca2 Btnl2 C3 C3ar1 C4a C4b Hc Adtrp Cacna1c Calca Calcrl Capn10 Casp1 Casq2 Casr Cbs Ccl11 Ccl12 Ccl22 Ccl5 Ccr2 Ccr5 Ccr9 Cd14 Cd36 Cd40 Cd40lg Cd44 Cd93 Cdh13 Cdkn1a Cdkn1c Cdkn2a Cdkn2b Celsr2 Cfh Chga Chi3l1 Chit1 Chrm2 Chrna5 Ciita Clec16a Clock Cma1 Cndp1 Cnr1 Col1a1 Col1a2 Comt Cp Cpb2 Cpe Creg1 Crp Csmd2 Cst3 Ctgf Ctss Cx3cr1 Cxcl10 Cxcl16 Cxcr1 Cxcr2 Cxcr4 Cyba Cyp11b2 Cyp11b1 Cyp17a1 Cyp19a1 Cyp1a1 Cyp1a2 Cyp24a1 Cyp26b1 Cyp2c65 Cyp2c66 Cyp2c29 Cyp2c38 Cyp2c39 Cyp2c55 Cyp2d10 Cyp2d11 Cyp2d12 Cyp2d34 Cyp2d9 Cyp2e1 Cyp2j6 Cyp4a10 Cyp4a31 Cyp4a32 Cyp4f18 Cyp7a1 Cysltr1 Ddah2 Ddx58 Dhx40 Dio2 Dnase1 Dpp4 Drd1a Ece1 Edn1 Ednra Efcab11 Egfr Egr1 Elane Enpp1 Epha2 Ephx1 Ephx2 Ercc2 Esr1 Esr2 F12 F13a1 F2 F2r F2rl3 F3 F5 F7 F8 F9 Fabp2 Fabp3 Fabp4 Fads1 Fads2 Fas Fcgr1 Fcgr3 Fga Fgb Fgf2 Fgf4 Fgfr4 Fgg Flad1 Flt1 Fn1 Foxo1 Foxp3 Ftl1 Fto Fut2 Gadd45b Galnt4 Gas6 Gata2 Gch1 Gck Gckr Gclc Gclm Gdf15 Ghrl Ghsr Gja4 Glis1 Glo1 Gnb3 Gosr2 Gp1ba Gp5 Gp6 Gpd1l Gpx1 Gria1 Gsk3b Gstm2 Gstp1 Gstp2 Gstt1 Gucy1a3 Gys1 Hba-a2 Hfe Hgf Hif1a Gm8909 H2-Bl H2-D1 H2-K1 H2-Q1 H2-Q2 H2-Q4 H2-Q6 H2-Q7 Hmgb1 Hmgcr Hmox1 Hnf1a Hnrnpul1 Hp Hrg Hsd11b1 Hsf1 Hspa1a Hspa1b Hspa2 Hspa4 Hspb1 Hspb7 Hspd1 Htr2a Icam1 Ifnb1 Ifng Igf1 Igf1r Igfbp1 Igfbp3 Il10 Il12b Il16 Il17a Il17f Il18 Il1a Il1b Il1r1 Il1r2 Il1rn Il23a Il4 Il5 Il6 Il6ra Il6st Ilf3 Insig1 Insig2 Irf5 Irs1 Irs2 Itga2 Itga2b Itgb3 Itih3 Itpr3 Kcne1l Kcnma1 Kcnq1 Kctd1 Kdr 1110008L16Rik 9430020K01Rik Kif6 Kl Klf14 Klf2 Klf5 Lama3 Lamp2 Lbp Lcat Lct Ldlr Lep Lgals2 Lias Lipc Lipg Lmna Lpl Lrp1 Lrp6 Lrp8 Lrpap1 Lsamp Lta Lta4h Ltbp1 Maoa Map1lc3a Mbl2 Mef2a Mfn2 Mgp Mia3 Mif Mkl1 Mlxipl Mmp1a Mmp12 Mmp2 Mmp3 Mmp7 Mmp8 Mmp9 Mpo Msra Mtap Mthfd1l Mthfr Mtr Mtrr Mttp Myb Nampt Nes Nfatc1 Nfe2l2 Nfkb1 Nfkbil1 Nod1 Nod2 Nos1 Nos1ap Nos2 Nos3 Nppa Npr1 Npr2 Npy Nr1h3 Nr1h4 Nr3c1 Nr3c2 Nr4a2 Oaz1 Olr1 Opcml Olfr309 P2rx7 P2ry12 P2ry2 Pafah1b1 Pafah1b3 Pappa Parp1 Pawr Pcdh15 Pcsk2 Pcsk5 Pcsk9 Pdcd1 Pde4d Pdgfb Pdgfd Pdx1 Pdxp Pecam1 Phactr1 Pla2g10 Pla2g7 Plat Plau Plaur Pld3 Plg Plin1 Pltp Pon1 Pon2 Pon3 Postn Ppara Ppard Pparg Ppargc1a Prkch Prkg2 Proc Procr Pros1 Prtn3 Psma5 Psma6 Pten Ptger2 Ptgis Ptgs2 Ptpn22 Ptpn9 Ptx3 Pvrl2 Ramp2 Ramp3 Rbp4 Rel Ren1 Retn Rgs2 Rhoa Ros1 Rpa1 Rpl7 Ryr3 S100a8 S100a9 S100b Saa1 Saa2 Scap Scarb1 Scn5a Scnn1g Sdc4 Sdk1 Sele Sell Selp Selplg Vimp Sema3f Sema4d Serpina1a Serpina1b Serpina1c Serpina1d Serpina1e Serpina12 Serpinb2 Serpinc1 Serpind1 Serpine1 Sftpd Sgms1 Sgms2 Sh2b3 Shbg Shc1 Sirt1 Slc22a3 Slc2a9 Slc6a4 Slc8a1 Smtn Soat1 Sod1 Sod2 Sod3 Sort1 Spp1 Src Srebf1 Srebf2 Stat4 Tbxa2r Tbxas1 Tcn2 Tdp1 Trf Tfpi Tgfb1 Tgfb2 Thbd Thbs1 Thbs2 Thbs4 Timp1 Timp2 Timp3 Timp4 Tlr2 Tlr4 Tlr5 Tlr9 Tmem121 Tnc Tnf Tnfaip3 Tnfrsf11b Tnfrsf1a Tnfrsf1b Tnfrsf4 Tnfsf11 Tnfsf4 Tnni3 Tnnt2 Trp53 Tpo Traf3ip2 Traf6 Trib1 Trpc4 Ttc32 Txnip Tyms Ucn Ucn2 Ucp2 Ugt1a1 Usf1 Uts2 Vamp8 Vcam1 Vdr Vegfa Vkorc1 Vldlr Vwf Wars Wdr35 Wnk1 Wrn Wwox Xrcc1 Xrcc3 Zfhx3 Zfp202 Zfp259 Zfp385b Zfp867

Extracellular Molecules Other Extracellular Molecules:

Plin2 Apoa1 Apob Apoe Ccl12 Ccl5 Csf2 Ctgf Fga Fgf2 Hbegf Ifnar2 Ifng Il1a Il2 Il4 Il5 Lama1 Lif Lpl Npy Pdgfa Pdgfb Spp1 Thbs4 Tnc Vegfa Vwf

Other Cytokine Receptor:

Tnfrsf11b

Cholesterol Biosynthesis:

Acaa2 Cnbp Cyb5r3 Cyp51 Dhcr24 Dhcr7 Fdft1 Fdps Hmgcr Hmgcs1 Hmgcs2 Idi1 Mvd Mvk Npc1l1 Nsdhl Pmvk Prkaa1 Prkaa2 Prkag2 Tm7sf2

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LncPath™ Cardiovascular Disease Microarrays