Long non-coding RNAs (lncRNAs) are pervasively transcribed in the genome and have emerged as new players in the cancer paradigm due to their functions in the transcriptional and posttranscriptional mechanisms of gene regulation. LncRNAs are dysregulated in a number of cancers, demonstrating their significant contributions to cancer progression in both oncogenic and tumor suppressive pathways.

The LncPath™ Human Cancer Array simultaneously profiles the expression of 2,829 LncRNAs and 1,906 of their protein-coding gene targets related to human cancer. The LncPath™ Mouse Cancer Array simultaneously profiles the expression of 3,104 LncRNAs and 3,206 of their protein-coding gene targets related to cancer. The LncRNAs whose genes are located at or near the protein-coding genes critical in the cancer pathways, and the LncRNAs that have high possibilities of being competing endogenous RNAs (ceRNAs) of the key cancer genes, are carefully collected from authoritative databases using rigorous selection processes. By focusing on the LncRNAs most relevant to the cancer pathways, the array can achieve much faster and more precise analysis, due to the highly specific yet smaller amount of data to analyze. More importantly, it can establish the expressional relationships between the LncRNAs and their protein-coding gene targets involved in the cancer pathways, thereby providing comprehensive insights into the underlying regulatory mechanisms of LncRNAs in cancers.

• Comprehensive and reliable collection of cancer focused LncRNAs.

• Simultaneous analysis of LncRNAs and their protein-coding gene targets in the pathways of cancer.

• Explore and establish expressional relationships and regulatory mechanisms between the LncRNAs and the target cancer genes.

• Faster and more precise cancer-specific analysis.

• Efficient and robust labeling system.

• Innovative probe design.

• Guaranteed performance.

An example showing the detailed information about the LncRNAs and their potential coding gene target

Click the LncRNA accession number listed in databases, you will see the figures showing the detailed information about the LncRNAs and their potential target gene.

Figure 1. The genomic map views of the LncRNA ENST00000554286 and its potential target gene ANG. From the top to the bottom of the figure 1, the following items are displayed:

Genome view: A chromosome ideogram showing the map position of the LncRNA ENST00000554286 and its potential target gene ANG (red bar).

Map view ruler: The map coordinates of the human genome assembly hg19 for the map views below.

LncRNA map view: The LncRNAs whose genes located at or near the ANG gene are presented in the Noncoding panel (shaded green). The LncRNAs are indicated by the transcript IDs, the exons by solid blocks, the introns by thin lines, and the transcription directions by arrows. The exons of LncRNA ENST00000554286 are labeled in red, while the exons of the other LncRNAs are labeled in blue.

Coding gene map view: The coding gene ANG is presented in the Coding panel (shaded blue). The coding gene is indicated by its canonical transcript ID, the exons by solid blocks, the introns by thin lines, and the transcription direction by arrows.

Figure 2. The relationship between LncRNA ENST00000554286 and its protein coding gene target ANG. The other neighboring LncRNAs which may regulate ANG expression are also shown.

Figure 3. The LncRNA ENST00000469255 may function as a competing endogenous RNA (ceRNA) of the protein coding gene ANG.
* MuTaMe Score, Mutually Targeted MRE Enrichment Score [1].

References
1.Tay, Y., et al., Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs. Cell, 2011. 147(2): p. 344-57.

List of LncRNAs

The LncRNAs collected for the human cancer pathways are listed in Table 1. Click an LncRNA accession number to see its detailed information and its potential target gene(s) in cancer.

Table 1. Human cancer pathway focused LncRNAs

Full List of Human Cancer Related LncRNAs.pdf

Gene List

The potential gene targets of the human cancer focused LncRNAs are listed in Table 2. Click the protein gene names to see the detailed information about the genes and their corresponding regulatory LncRNAs in cancer.

Table 2. Functional gene grouping

List of LncRNAs

The LncRNAs collected for the mouse cancer pathways are listed in Table 1. Click an LncRNA accession number to see its detailed information and its potential target gene(s) in cancer.

Table 1. Mouse cancer pathway focused LncRNAs

Full List of Mouse Cancer Related LncRNAs.pdf

Gene List

The potential gene targets of the mouse cancer focused LncRNAs are listed in Table 2. Click the protein gene names to see the detailed information about the genes and their corresponding regulatory LncRNAs in cancer.

Table 2. Functional gene grouping