Apoptosis is a form of programmed cell death that plays an important role in cell and tissue homeostasis and in growth control. The proper regulation of apoptosis is essential for the survival of multicellular organisms, and deregulation of this process is associated with a wide variety of human diseases including cancer, neurodegeneration diseases, cardiovascular disorders and autoimmune diseases. The molecular mechanisms behind apoptosis are not fully understood. Recent research has suggested the essential roles of LncRNAs in the regulation of apoptosis.

The LncPath™ Human Apoptosis Pathway LncRNA Microarray simultaneously profiles the expression of 1,451 LncRNAs and 514 their potential coding targets related to the apoptosis signaling pathway. The LncPath™ Mouse Apoptosis Pathway LncRNA Microarray simultaneously profiles the expression of 817 LncRNAs and 856 their potential coding targets related to the apoptosis signaling pathway. The LncRNAs whose genes are located at or near the protein-coding genes critical in the apoptosis pathway, and the LncRNAs that have high possibilities of being competing endogenous RNAs (ceRNAs) of the key apoptosis genes, are carefully collected from authoritative databases using rigorous selection processes. By focusing on the LncRNAs most relevant to the apoptosis pathway, the array can achieve much faster and more precise analysis, due to the highly specific yet smaller amount of data to analyze. More importantly, it can establish the expressional relationships between the LncRNAs and their protein-coding gene targets involved in the apoptosis signaling pathway, thereby providing comprehensive insights into the underlying regulatory mechanisms of LncRNAs in apoptosis.

• Comprehensive and reliable collection of apoptosis pathway focused LncRNAs.

• Simultaneous analysis of LncRNAs and their protein-coding gene targets in the apoptosis pathway.

• Explore and establish expressional relationships and regulatory mechanisms between the LncRNAs and the target pathway genes.

• Faster and more precise pathway-focused analysis.

• Efficient and robust labeling system.

• Innovative probe design.

• Guaranteed performance.

An example showing the detailed information about the LncRNAs and their potential coding gene target

Click the LncRNA accession number listed in databases, you will see the figures showing the detailed information about the LncRNAs and their potential target gene.

Figure 1. The genomic map views of the LncRNA ENST00000412972 and its potential target gene BCL2L1. From the top to the bottom of the figure 1, the following items are displayed:

Genome view: A chromosome ideogram showing the map position of the LncRNA ENST00000412972 and its potential target gene BCL2L1 (red bar).

Map view ruler: The map coordinates of the human genome assembly hg19 for the map views below.

LncRNA map view: The LncRNAs whose genes located at or near the BCL2L1 gene are presented in the Noncoding panel (shaded green). The LncRNAs are indicated by the transcript IDs, the exons by solid blocks, the introns by thin lines, and the transcription directions by arrows. The exons of LncRNA ENST00000412972 are labeled in red, while the exons of the other LncRNAs are labeled in blue.

Coding gene map view: The coding gene BCL2L1 is presented in the Coding panel (shaded blue). The coding gene is indicated by its canonical transcript ID, the exons by solid blocks, the introns by thin lines, and the transcription direction by arrows.

Figure 2. The relationship between LncRNA ENST00000412972 and its protein coding gene target BCL2L1. The other neighboring LncRNAs which may regulate BCL2L1 expression are also shown.

Figure 3. The LncRNA ENST00000566270 may function as a competing endogenous RNA (ceRNA) of the protein coding gene BCL2L1.

* MuTaMe Score, Mutually Targeted MRE Enrichment Score [1].

References
1.Tay, Y., et al. (2011) Cell 147 (2): 344-57.

List of LncRNAs

The LncRNAs collected for human apoptosis pathway are listed in Table 1. Click an LncRNA accession number to see its detailed information and its potential target gene(s) in the apoptosis pathway.

Table 1. Human apoptosis pathway focused LncRNAs

Full list of Human Apoptosis Pathway Focused LncRNAs.pdf

Gene List

The potential gene targets of human apoptosis pathway focus LncRNAs are listed in Table 2. Click the protein gene names to see the detailed information about the genes and their corresponding regulatory LncRNAs in the apoptosis pathway.

Table 2. Functional gene grouping

List of LncRNAs

The LncRNAs collected for mouse apoptosis pathway are listed in Table 1. Click an LncRNA accession number to see its detailed information and its potential target gene(s) in the apoptosis pathway.

Table 1. Mouse apoptosis pathway focused LncRNAs

Gene List

The potential gene targets of mouse apoptosis pathway focus LncRNAs are listed in Table 2. Click the protein gene names to see the detailed information about the genes and their corresponding regulatory LncRNAs in the apoptosis pathway.

Table 2. Functional gene grouping