Angiogenesis is a vital process of new blood vessel formation.  It is a highly regulated process that occurs during normal human development, reproduction, and wound healing.  An angiogenic imbalance contributes to numerous malignant, inflammatory, ischemic, infectious and immune disorders [1,2]. The molecular mechanisms behind angiogenesis are not fully understood. Recent research has suggested the essential roles of LncRNAs in the regulation of angiogenesis.

The LncPath™ Human Angiogenesis Pathway LncRNA Microarray simultaneously profiles the expression of 828 LncRNAs and 251 their potential coding targets related to the angiogenesis signaling pathway. The LncPath™ Mouse Angiogenesis Pathway LncRNA Microarray simultaneously profiles the expression of 339 LncRNAs and 448 their potential coding targets related to the angiogenesis signaling pathway. The LncRNAs whose genes are located at or near the protein-coding genes critical in the angiogenesis pathway, and the LncRNAs that have high possibilities of being competing endogenous RNAs (ceRNAs) of the key angiogenesis genes, are carefully collected from authoritative databases using rigorous selection processes. By focusing on the LncRNAs most relevant to the angiogenesis pathway, the array can achieve much faster and more precise analysis, due to the highly specific yet smaller amount of data to analyze. More importantly, it can establish the expressional relationships between the LncRNAs and their protein-coding gene targets involved in the angiogenesis signaling pathway, thereby providing comprehensive insights into the underlying regulatory mechanisms of LncRNAs in angiogenesis.

• Comprehensive and reliable collection of angiogenesis pathway focused LncRNAs.

• Simultaneous analysis of LncRNAs and their protein-coding gene targets in the angiogenesis pathway.

• Explore and establish expressional relationships and regulatory mechanisms between the LncRNAs and the target pathway genes.

• Faster and more precise pathway-focused analysis.

• Efficient and robust labeling system.

• Innovative probe design.

• Guaranteed performance.

An example showing the detailed information about the LncRNAs and their potential coding gene target

Click the LncRNA accession number listed in databases, you will see the figures showing the detailed information about the LncRNAs and their potential target gene.

Figure 1. The genomic map views of the LncRNA NR-040772 and its potential target gene ADAM15. From the top to the bottom of the figure 1, the following items are displayed:

Genome view: A chromosome ideogram showing the map position of the LncRNA NR-040772 and its potential target gene ADAM15(red bar).

Map view ruler: The map coordinates of the human genome assembly hg19 for the map views below.

LncRNA map view: The LncRNAs whose genes located at or near the ADAM15 gene are presented in the Noncoding panel (shaded green). The LncRNAs are indicated by the transcript IDs, the exons by solid blocks, the introns by thin lines, and the transcription directions by arrows. The exons of LncRNA NR-040772 are labeled in red, while the exons of the other LncRNAs are labeled in blue.

Coding gene map view: The coding gene ADAM15 is presented in the Coding panel (shaded blue). The coding gene is indicated by its canonical transcript ID, the exons by solid blocks, the introns by thin lines, and the transcription direction by arrows.

Figure 2. The relationship between LncRNA NR-040772 and its protein coding gene target ADAM15. The other neighboring LncRNAs which may regulate ADAM15 expression are also shown.

Figure 3. The LncRNA ENST00000518798 may function as a competing endogenous RNA (ceRNA) of the protein coding gene ADAM15.

* MuTaMe Score, Mutually Targeted MRE Enrichment Score [3].

References
1. Nussenbaum, F. and I. M. Herman (2010) J Oncol 2010: 132641.
2. Carmeliet, P. (2005) Nature 438 (, 7070): 932-6.
3. Tay, Y., et al. (2011) Cell 147 (2): 344-57.

List of LncRNAs

The LncRNAs collected for human angiogenesis pathway are listed in Table 1. Click an LncRNA accession number to see its detailed information and its potential target gene(s) in the angiogenesis pathway.

Table 1. Human angiogenesis pathway focused LncRNAs

Full List of Human Angiogenesis Pathway Focused LncRNAs.pdf

Gene List

The potential gene targets of human angiogenesis pathway focus LncRNAs are listed in Table 2. Click the protein gene names to see the detailed information about the genes and their corresponding regulatory LncRNAs in the angiogenesis pathway.

Table 2. Functional gene grouping

List of LncRNAs

The LncRNAs collected for mouse angiogenesis pathway are listed in Table 1. Click an LncRNA accession number to see its detailed information and its potential target gene(s) in the angiogenesis pathway.

Table 1. Mouse angiogenesis pathway focused LncRNAs

Full List of Mouse Angiogenesis Pathway Focused LncRNAs.pdf

Gene List 

The potential gene targets of mouse angiogenesis pathway focus LncRNAs are listed in Table 2. Click the protein gene names to see the detailed information about the genes and their corresponding regulatory LncRNAs in the angiogenesis pathway.

Table 2. Functional gene grouping