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Since opening in 2009, Arraystar Inc. has successfully provided services for hundreds of esteemed universities, hospitals, and research centers, including NIH, FDA, UCSD, Rockefeller University, Columbia University, University of Toronto, M. D. Anderson Cancer Center and many others.

LncRNA Microarrays & Services

The LINK-A lncRNA interacts with PtdIns (3, 4, 5) P3 to hyperactivate AKT and confer resistance to AKT inhibitors. Lin A, et al. Nature Cell Biology, 2017 

A novel lncRNA GClnc1 promotes gastric carcinogenesis and may act as a modular scaffold of WDR5 and KAT2A complexes to specify the histone modification pattern. Sun T T, et al. Cancer discovery, 2016

Integrative Transcriptome Analyses of Metabolic Responses in Mice Define Pivotal LncRNA Metabolic Regulators.Yang L, et al.  Cell Metabolism, 2016.

Differential transcriptome expression in human nucleus accumbens as a function of loneliness. Canli T, et al. Molecular Psychiatry​, 2016

Long noncoding RNA Tug1 regulates mitochondrial bioenergetics in diabetic nephropathy. Long J, et al. The Journal of Clinical Investigation, 2016

Long Non-coding RNA DILC Represses Self-renewal of Liver Cancer Stem Cells via Inhibiting Autocrine IL-6/STAT3 Axis. X Wang, et al. Journal of Hepatology, 2016

An acetyl-L-carnitine switch on mitochondrial dysfunction and rescue in the metabolomics study on aluminum oxide nanoparticles.Li X, et al.Particle and Fibre Toxicology, 2016

Long non-coding RNA LINC00092 acts in cancer-associated fibroblasts to drive glycolysis and progression of ovarian cancer. Zhao L, et al. Cancer Research, 2017

Integrative Functional Transcriptomic Analyses Implicate Specific Molecular Pathways in pulmonary toxicity from Exposure to Aluminum Oxide Nanoparticles. Li X, et al.Nanotoxicology,2016

A novel lncRNA uc. 134 represses hepatocellular carcinoma progression by inhibiting CUL4A-mediated ubiquitination of LATS1.Ni W,et al.Journal of Hematology & Oncology, 2017

Circulating “lncRNA OTTHUMT00000387022” from Monocytes as a Novel Biomarker for Coronary Artery Disease. Yue Cai, et al. Cardiovascular Research, 2016

DC-SIGNR by influencing the lncRNA HNRNPKP2 upregulates the expression of CXCR4 in gastric cancer liver metastasis. Zhang Y, et al. Molecular Cancer, 2017

LncRNAs expression profiling in normal ovary, benign ovarian cyst and malignant epithelial ovarian cancer. Wang H,  et al. Scientific Reports, 2016

LncRNA-N1LR Enhances Neuroprotection Against Ischemic Stroke Probably by Inhibiting p53 Phosphorylation. Wu Z, et al. Molecular Neurobiology, 2016

Microarray Analysis of lncRNA and mRNA Expression Profiles in Patients with Neuromyelitis Optica. Xu J, et al. Molecular Neurobiology, 2016

Long noncoding RNA related to periodontitis interacts with miR-182 to upregulate osteogenic differentiation in periodontal mesenchymal stem cells of periodontitis patients. Wang L, et al. Cell Death & Disease, 2016.

Comprehensive analysis of differentially expressed profiles of lncRNAs and circRNAs with associated co-expression and ceRNA networks in bladder carcinoma.Mengge Huang, et al.Oncotarget,2016

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Arraystar circRNA microarray & service
Circular RNA MTO1 acts as the sponge of miR-9 to suppress hepatocellular carcinoma progression. Han D, et al. Hepatology (Baltimore, Md.), 2017 

circRNA_100290 plays a role in oral cancer by functioning as a sponge of the miR-29 family. Chen L, et al. Oncogene, 2017    

Changing expression profiles of lncRNAs, mRNAs, circRNAs and miRNAs during osteoclastogenesis. Dou C, et al. Scientific Reports, 2016

Circular RNA Related to the Chondrocyte ECM Regulates MMP13 Expression by Functioning as a MiR-136 'Sponge' in Human Cartilage Degradation. Liu Q, et al. Scientific Reports, 2016

CircRNA_000203 enhances the expression of fibrosis-associated genes by derepressing targets of miR-26b-5p, Col1a2 and CTGF, in cardiac fibroblasts. Tang C M,  et al.Scientific Reports, 2017

Circ100284, via miR-217 regulation of EZH2, is involved in the arsenite-accelerated cell cycle of human keratinocytes in carcinogenesis. Xue J,  et al. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 2017

Comprehensive analysis of differentially expressed profiles of lncRNAs and circRNAs with associated co-expression and ceRNA networks in bladder carcinoma. Mengge Huang, et al.Oncotarget,2016

Characterization of hsa_circ_0004277 as a New Biomarker for Acute Myeloid Leukemia via Circular RNA Profile and Bioinformatics Analysis. Li W, et al. International Journal of Molecular Sciences, 2017

Microarray profiling of circular RNAs in human papillary thyroid carcinoma. Peng N, et al. PloS one, 2017

Identification of differentially expressed circular RNAs in human colorectal cancer. Zhang P, et al. Tumor Biology, 2017      

A novel identified circular RNA, circRNA_010567, promotes myocardial fibrosis via suppressing miR-141 by targeting TGF-β1. Zhou B, Xu H Y. Biochemical and Biophysical Research Communications, 2017     

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Arraystar gene expression microarray service
MicroRNA Signatures and Molecular Subtypes of Glioblastoma: The Role of Extracellular Transfer. Godlewski J, et al. Stem Cell Reports, 2017

Bmal1 is required for beta cell compensatory expansion, survival and metabolic adaptation to diet-induced obesity in mice. Rakshit K, et al.Diabetologia,2016

PMP22 Regulates Self-Renewal and Chemoresistance of Gastric Cancer Cells. Cai W, et al. Molecular Cancer Therapeutics, 2017   

ABCF2, an Nrf2 target gene, contributes to cisplatin resistance in ovarian cancer cells. L Bao, et al. Molecular Carcinogenesis​, 2017

Bifunctional enzyme SpoT is involved in the clarithromycin tolerance of Helicobacter pylori by up-regulating the transporters HP0939, HP1017, HP0497, and HP0471. Geng X,et al. Antimicrobial Agents and Chemotherapy, 2017

Silencing of CD40 in vivo reduces progression of experimental atherogenesis through an NF-κB/miR-125b axis and reveals new potential mediators in the pathogenesis of atherosclerosis. Hueso M, et al. Atherosclerosis​, 2016

Gene expression profiling and bioinformatics analysis in 16HBE cells treated by chromium (VI). Hu G, et al. Toxicology Letters​, 2016

Altered metabolic activity in the developing brain of rats predisposed to high versus low depression-like behavior CR McCoy, et al. Neuroscience, 2016

Coding and non-coding gene regulatory networks underlie the immune response in liver cirrhosis. Gao B, et al. PloS one, 2017 

Regulation of membrane fixation and energy production/conversion for adaptation and recovery of ZnO nanoparticle impacted Nitrosomonas europaea, Wu J,et al. Applied Microbiology and Biotechnology, 2017 

Metabolic perturbation of epigenome by inhibiting S-adenosylhomocysteine hydrolase elicits senescence through DNA damage response in hepatoma cells. Wu G,  et al. Tumor Biology, 2017

Pleiotropic Effect of a High Resolution Mapped Blood Pressure QTL on Tumorigenesis.Cheng X, et al.PLoS ONE,2016

Gene expression profiles of human lung epithelial cells chronically exposed to single-walled carbon nanotubes. D Chen, et al. Nanoscale Research Letters, 2015

Genetic predisposition to high anxiety-and depression-like behavior coincides with diminished DNA methylation in the adult rat amygdala. McCoy C R,  et al. Behavioural Brain Research, 2016

Global expression profile of tumor stem-like cells isolated from MMQ rat prolactinoma cell. Z Su, et al. Cancer Cell International, 2017

Identification of gene signatures regulated by carvedilol in mouse heart. Jian-peng Teoh, et al.Physiol Genomics, 2016.

Transcriptome reveals the overexpression of a kallikrein gene cluster (KLK1/3/7/8/12) in the Tibetans with high altitude-associated polycythemia. International Journal of Molecular Medicine. 2016

Prognostic Significance of MAGE-A11 in Esophageal Squamous Cell Carcinoma and Identification of Related Genes Based on DNA Microarray. Sang M, et al. Archives of Medical Research, 2016

Role of MAPK/ERK signal pathway in recurrent miscarriage patients by case-control analysis. Wang Y,et al. Int J Clin Exp Pathol, 2016

SPARC overexpression suppresses radiation-induced HSP27 and induces the collapse of mitochondrial Δψ in neuroblastoma cells. Tanpure S, et al. Oncology Letters. 2017

Genome‑scale transcriptional analysis reveals key genes associated with the development of type II diabetes in mice. Zhang Y, et al. Experimental and Therapeutic Medicine, 2017

Whole genome expression microarray analysis of highly versus poorly tumorigenic murine melanoma cell lines provides insights into factors that regulate tumor growth, metastasis, and immunogenicity. Kristian Michael Hargadon,et al.  Frontiers in Immunology, 2015

miR-17-92 Cluster Promotes Cholangiocarcinoma Growth: Evidence for PTEN as Downstream Target and IL-6/Stat3 as Upstream Activator. H Zhu, et al. The American Journal of Pathology, 2014

Sucrose non-fermenting related kinase enzyme is essential for cardiac metabolism. Cossette SM, et al. Biol Open, 2014

Global Effect of Inauhzin on Human p53-Responsive Transcriptome. Jun-Ming Liao, et al. PLoS ONE, 2012

Chronic occupational exposure to arsenic induces carcinogenic gene signaling networks and neoplastic transformation in human lung epithelial cells. Todd A. Stueckle, et al. Toxicology and Applied Pharmacology, 2012

MeCP2 promotes gastric cancer progression through regulating FOXF1/Wnt5a/β-Catenin and MYOD1/Caspase-3 signaling pathways. Zhao L, et al. EBioMedicine, 2017

Arraystar piRNA microarray & service
RASSF1C modulation of Piwi-interacting RNAs (piRNAs) in lung cancer.YG Amaar, et al.Cancer Research,2016

Roles of piRNAs in microcystin-leucine-arginine (MC-LR) induced reproductive toxicity in testis on male offspring. Zhang L, et al. Food and Chemical Toxicology, 2017    

Piwi-interacting RNAs as novel prognostic markers in clear cell renal cell carcinomas. J Busch, et al. J Exp Clin Cancer Res, 2015

Altered Expression of PIWI RNA in the Rat Brain After Transient Focal Ischemia. Ashutosh Dharap, Venkata Prasuja Nakka and Raghu Vemuganti. STROKEAHA, 2010.

Arraystar LncPath™ Pathway Array Service
circRNA_100290 plays a role in oral cancer by functioning as a sponge of the miR-29 family. Chen L, et al. Oncogene, 2017   

Aberrantly expressed long noncoding RNAs are involved in sevoflurane-induced developing hippocampal neuronal apoptosis: a microarray related study.X Chen et al.Metabolic Brain Disease, 2016

Detection and Analysis of Wnt Pathway Related lncRNAs Expression Profile in Lung Adenocarcinoma. Chen J, et al. Pathology & Oncology Research, 2016

Decreased expression of long noncoding RNA MT1JP may be a novel diagnostic and predictive biomarker in gastric cancer. Yang J, et al. Int J Clin Exp Pathol, 2017

Expression of LOC285758, a potential long non-coding biomarker, is methylation-dependent and correlates with glioma malignancy grade. Matjasic A, et al. Radiology and Oncology, 2017

Arraystar T-UCR Array Service
Noncoding Transcribed Ultraconserved Region (T-UCR) uc.261 Participates in Intestinal Mucosa Barrier Damage in Crohn's Disease. Qian X X, et al. inflammatory bowel diseases, 2016

Arraystar MeDIP-chip service
MSC Transplantation Improves Osteopenia via Epigenetic Regulation of Notch Signaling in Lupus. Shiyu Liu, et al. Cell Metabolism, 2016

TET3 Mediates Alterations in the Epigenetic Marker 5hmC and Akt Pathway in Steroid‐Associated Osteonecrosis. Zhao J, et al. Journal of Bone and Mineral Research, 2016

TFIIS. h, a new target of p53, regulates transcription efficiency of pro-apoptotic bax gene. JM Liao, et al. Scientific Reports, 2016

Epigenetic inactivation of the CpG demethylase TET1 as a DNA methylation feedback loop in human cancers. Li L, et al. Scientific reports​, 2016

Sox9 transcriptionally regulates Wnt signaling in intestinal epithelial stem cells in hypomethylated crypts in the diabetic state. Huang C Z, et al. Stem Cell Research & Therapy, 2017

Increased 5‐hydroxymethylation levels in the hippocampus of rat extinguished from cocaine self‐administration. Sadakierska‐Chudy A, et al. Hippocampus, 2017

Dietary Chromium Restriction of Pregnant Mice Changes the Methylation Status of Hepatic Genes Involved with Insulin Signaling in Adult Male Offspring. Zhang Q, et al. PLOS ONE, 2017

Genome-Wide DNA Methylation in Mixed Ancestry Individuals with Diabetes and Prediabetes from South Africa. Matsha T E, et al. International Journal of Endocrinology​, 2016

DNA methylation differences in monozygotic twin pairs discordant for schizophrenia identifies psychosis related genes and networks. Castellani CA, et al. BMC Med Genomics, 2015

Long-term parental methamphetamine exposure of mice influences behavior and hippocampal DNA methylation of the offspring. Y Itzhak, et al. Molecular Psychiatry, 2014

Characterization of the nasopharyngeal carcinoma methylome identifies aberrant disruption of key signaling pathways and methylated tumor suppressor genes. Li L, et al.Epigenomics, 2014

Olanzapine-induced methylation alters cadherin gene families and associated pathways implicated in psychosis. MG Melka, et al. BMC Neuroscience, 2014.

Olanzapine-induced DNA methylation in the hippocampus and cerebellum in genes mapped to human 22q11 and implicated in schizophrenia. MG Melka, et al.Psychiatric genetis, 2014.

Long lasting alterations to DNA methylation and ncRNAs may underlie the effects of fetal alcohol exposure. Benjamin I. Laufer, et al. Disease Models & Mechanisms, 2013.

Olanzapine induced DNA methylation changes support the dopamine hypothesis of psyhosis. Melkaye G Melka, et al. Journal of Molecular Psychiatry, 2013.

P10-017 Volatile biomarkers of cisplatin-induced toxicity in vitro. R. Fijten, et al. Abstracts / Toxicology Letters, 2015

A Long-Term Neuroepigenomic Profile of Prenatal Alcohol Exposure. Benjamin I. Laufer. Electronic Thesis and Dissertation Repository.Paper 3913, 2016

Arraystar RNA sequencing service
Genome-wide Identification of Long Noncoding RNAs in Rat Models of Cardiovascular and Renal Diseases. K Gopalakrishnan, et al. Hypertension, 2014

Arraystar microRNA sequencing service 
Next-generation sequencing of the basal cell carcinoma miRNome and a description of novel microRNA candidates under neoadjuvant vismodegib therapy: an integrative molecular and surgical case study.Sand M, et al.Ann Oncol,2016

Molecular fingerprinting of the podocyte reveals novel gene and protein regulatory networks. Melanie Boerries, et al. Kidney International, 2013

Integrated analysis of dysregulated ncRNA and mRNA expression profiles in humans exposed to carbon nanotubes. Shvedova A A, et al. PloS one, 2016

Survival and Diversity of Human Homologous Dietary MicroRNAs in Conventionally Cooked Top Sirloin and Dried Bovine Tissue Extracts. Dever J T, et al. PloS one, 2015

MicroRNA Expression Varies according to Glucose Tolerance, Measurement Platform, and Biological Source. Dias S,et al. BioMed Research International, 2017

Arraystar ChIP-sequencing service
The LINK-A lncRNA activates normoxic HIF1 [alpha] signalling in triple-negative breast cancer. Lin A,et al. Nature cell biology, 2016

Direct Transcriptional Effects of Apolipoprotein E. Veena Theendakara, et al. Neurobiology of Disease, 2016

Role for Dpy-30 in ES Cell-Fate Specification by Regulation of H3K4 Methylation within Bivalent Domains. Hao Jiang, et al. Cell, 2011.

Oxidized Guanine Base Lesions Function in 8-Oxoguanine DNA Glycosylase1-Mediated Epigenetic Regulation of Nuclear Factor kappaB-Driven Gene Expression. Pan L, et al. Journal of Biological Chemistry, 2016.

Arraystar MeDIP(h
MeDIP)-sequencing service
Loss of Endometrial Plasticity in Recurrent Pregnancy Loss Emma S. Lucas,et al. Stem cells, 2016.

Differential DNA methylation of microRNAs within promoters, intergenic and intragenic regions of type 2 diabetic, pre-diabetic and non-diabetic individuals. C Pheiffer,et al. Clinical Biochemistry, 2016.

Genome-wide DNA methylation in mixed ancestry individuals with diabetes and prediabetes from South Africa.TE Matsha, et al. 2016

Dynamic interplay between locus-specific DNA methylation and hydroxymethylation regulates distinct biological pathways in prostate carcinogenesis. Shivani N,et al. Clinical Epigenetics, 2015

Parp inhibition prevents ten eleven translocase enzyme activation and hyperglycemia induced DNA demethylation. Dhliwayo N, et al. Diabetes, 2014.

Characterization of the DNA methylome and its interindividual variation in human peripheral blood monocytes. Hui Shen, et al. Epigenomics, 2013.

Heritable Transmission of Diabetic Metabolic Memory in Zebrafish Correlates With DNA Hypomethylation and Aberrant Gene Expression. Ansgar S. Olsen, et al. Diabetes, 2012.

Arraystar CLIP-sequencing service
Intronic RNAs mediate EZH2 regulation of epigenetic targets. Sonia Guil, et al. Nature Structural & Molecular Biology, 2012

Real-Time qPCR Reagents and Kits
Mir-344b-1-3p targets Tlr2 and negatively regulates Tlr2 signaling pathway. Wu Y,  et al. International Journal of COPD, 2017

Anxiety-like behavior and dysregulation of miR-34a in triple transgenic mice of Alzheimer’s disease​. Y.-L. Zhang, et al. Eur Rev Med Pharmacol Sci ​, 2016

Physiological and transcriptional responses of Nitrosomonas europaea to TiO2 and ZnO nanoparticles and their mixtures. Yu R, Wu J, Liu M, et al. Environmental Science and Pollution Research, 2016   

Long noncoding RNA HAS2‐AS1 mediates hypoxia‐induced invasiveness of oral squamous cell carcinoma. Zhu G, et al. Molecular Carcinogenesis, 2017  
 

 

Seq-Star™ NGS Solutions
circRNA_100290 plays a role in oral cancer by functioning as a sponge of the miR-29 family. Chen L, et al. Oncogene, 2017 

Integrative analysis for the role of long non-coding RNAs in radiation-induced mouse thymocytes responses. Hui Gao, et al. Acta Biochimica et Biophysica Sinica, 2016