• Description
  • Highlights
  • Human Database
  • Mouse Database
Product NameCatalog NoDescriptionFormatPrice
LncPath™ Mouse Wnt Pathway Microarray AS-LP-001M 1,033 LncRNAs and 808 potential coding targets 8*15K
LncPath™ Human Wnt Pathway Microarray AS-LP-001H 1,317 LncRNAs and 476 potential coding targets 8*15K

The Wnt pathway is important in tumorigenesis and developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division [1, 2].

The LncPath™ Human Wnt Pathway LncRNA Microarray simultaneously profiles the expression of 1,317 LncRNAs and 476 of the potential coding genes related to the Wnt signaling pathway. The LncPath™ Mouse Wnt Pathway LncRNA Microarray simultaneously profiles the expression of 1,033 LncRNAs and 808 of the potential coding genes related to the Wnt signaling pathway. Using this array, scientists can leverage the pre-designed panel as a powerful tool to quickly generate expression data for both the lncRNAs and their potential coding gene targets in the Wnt signaling pathway, while gaining comprehensive insights into the underlying regulatory mechanisms of LncRNAs in the Wnt pathway.

Reliable Wnt pathway focus LncRNA collection
Simultaneous analysis of LncRNAs and their potential coding gene targets related to the Wnt pathway
Efficient and robust labeling system
Innovative probe design
Guaranteed performance

An example of the figures showing the detailed information about the LncRNAs and their potential coding gene targets
Click the LncRNA accession number listed in databases, you will see the figures showing the detailed information about the LncRNAs and their potential target gene.


Figure 1. The genomic map views of the LncRNA ENST00000450624 and its potential target gene ABCB1. From the top to the bottom of the figure 1, the following items are demonstrated:
Genome view: A chromosome ideogram showing the map position of the LncRNA ENST00000450624 and its potential target gene ABCB1(red bar).
Map view ruler: The map coordinates of the human genome assembly hg19 for the map views below.
LncRNA map view: The LncRNAs whose genes located at or near the ABCB1 gene are presented in the Noncoding panel (shaded blue). The LncRNAs are indicated by the transcript IDs, the exons by solid blocks, the introns by thin lines, and the transcription directions by arrows. The exons of LncRNA ENST00000450624 are labeled in red, while the exons of the other LncRNAs are labeled in blue.
Coding gene map view: The coding gene ABCB1 is presented in the Coding panel (shaded green). The coding gene is indicated by its canonical transcript ID, the exons by solid blocks, the introns by thin lines, and the transcription direction by arrows.


Figure 2. The relationship between LncRNA ENST00000450624 and its protein coding gene target ABCB1. The other neighboring LncRNAs which may regulate ABCB1 expression are also shown.


Figure 3. The LncRNA ENST00000498734 may function as a competing endogenous RNA (ceRNA) of the protein coding gene ABCB1.
* MuTaMe Score, Mutually Targeted MRE Enrichment Score [3].

References1.    Anastas, J.N. and R.T. Moon, WNT signalling pathways as therapeutic targets in cancer. Nat Rev Cancer, 2013. 13(1): p. 11-26.
2.    Saito-Diaz, K., et al., The way Wnt works: components and mechanism. Growth Factors, 2013. 31(1): p. 1-31.
3.   Tay, Y., et al., Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs. Cell, 2011. 147(2): p. 344-57.

LncRNA List
The human Wnt pathway LncRNAs are listed in Table 1. Click the LncRNA accession numbers to see the detailed information about the LncRNAs and their potential coding gene targets in the Wnt pathway.

Table 1. Human WNT pathway focused LncRNAs

ENST00000261034 ENST00000265259, ENST00000279573, ENST00000289890, ENST00000314747, ENST00000331871, ENST00000333854, ENST00000339626, ENST00000369391, ENST00000370176, ENST00000379963, ENST00000381361, ENST00000406997, ENST00000411661, ENST00000411838, ENST00000412067, ENST00000412638, ENST00000412951, ENST00000413053, ENST00000413334, ENST00000414529, ENST00000414600, ENST00000414927, ENST00000415054, ENST00000415202, ENST00000415246, ENST00000415330, ENST00000416139, ENST00000416310, ENST00000417089, ENST00000417460, ENST00000417514, ENST00000417844, ENST00000419225, ENST00000419364, ENST00000419382, ENST00000419531, ENST00000419609, ENST00000419644, ENST00000419682, ENST00000419944, ENST00000420193, ENST00000420452, ENST00000420537, ENST00000421298, ENST00000421965, ENST00000422040, ENST00000422408, ENST00000422703, ENST00000422776, 

Full List of Human Wnt Pathway Focused LncRNAs.pdf

Gene List
The potential gene targets of the human WNT pathway focus LncRNAs are listed in Table 2. Click the protein gene names to see the detailed information about the genes and their corresponding regulatory LncRNAs in the WNT pathway.

Table 2. Functional gene grouping

target relevant Signaling Pathways:
GDF5 ID2 LRP1 PPAP2B PTCH1
Adhesion:
CTGF
WNT RECEPTORS:
FZD1 FZD10 FZD2 FZD3 FZD4 FZD5 FZD6 FZD7 FZD8 FZD9 KREMEN1 KREMEN2 LDLR LRP5 LRP6 RYK SMO
Cell Cycle:
AHR ID2
WNT Signaling Targets:
ABCB1 AHR ANGPTL4 ANTXR1 AXIN2 BGLAP BIRC5 BMP4 BTRC CACNA2D3 CCND1 CCND2 CD44 CDH1 CDKN2A CDON CEBPD CTGF CUBN DAB2 DKK1 DLK1 DPP10 EFNB1 EGFR EGR1 ETS2 FGF20 FGF4 FGF7 FGF9 FN1 FOSL1 FST FZD7 GDF5 GDNF GJA1 ID2 IGF1 IGF2 IL6 IRS1 JAG1 KLF5 LEF1 LRP1 MET MMP2 MMP7 MMP9 MYC NANOG NRCAM NRP1 NTRK2 PDGFRA PITX2 PLAUR POU5F1 PPAP2B PPARD PTCH1 PTGS2 RUNX2 SFRP2 SIX1 SMO SOX2 SOX9 T TCF4 TCF7 TCF7L1 TCF7L2 TGFB3 TLE1 TWIST1 VEGFA WISP1 WISP2 WNT3A WNT5A WNT9A
oncogene:
BCL9 CDX1 CTNNB1 CXCL1 EGFR FER FGF4 FGFR1 FGFR2 FOSL1 FRAT1 FRAT2 FYN GLI1 GLI2 GLI3 GOPC HGF HRAS JUN KRAS KRT14 MAEA MITF MMP7 MYB MYC MYCN PDGFB PIK3CG PLAUR PRKCI PTTG1 RAB14 RUNX2 SOS1 SRC TIAM1 WNT1 WNT10B WNT3 WNT7A
Calcium Binding and Signaling:
CACNA2D3 CUBN LRP1
tumor suppressor:
ABCB1 ABL1 AKT1 APC AR ARRB2 AXIN1 AXIN2 BIRC5 BSG BTG3 BTRC CAV1 CBY1 CCND1 CCND2 CCND3 CDC73 CDH1 CDKN1A CDKN2A CREBBP CUL2 CYR61 DDX5 DKK1 DKK3 DLG3 DLK1 E2F1 EDN1 ENC1 EPHB2 FAS FHIT FOXO1 FOXO3 GAS1 GSK3B HBP1 HDAC1 HDAC2 HDAC3 IFNG IGF1 IGF1R IGF2R IGFBP4 IL6 KLF4 KLF5 MAP3K7 MAPK1 MAPK14 MAPK9 MET MMP2 NFKB1 NFKB2 PIK3CA PPARD PPM1A PPM1D PPM1L PPP2R2B PRICKLE1 PRKAR1A PRKCD PTEN PTGS2 RARG RHOB SDC2 SFRP1 SFRP2 SFRP4 SFRP5 SIAH1 SIRT1 SLC9A3R1 SMAD2 SMAD3 SMAD4 SMAD5 SMARCA4 SMO SOX4 SOX7 SPP1 SUFU TCF4 TCF7 TGFB1 TJP1 TNF VHL WIF1 WNT5A YWHAQ YWHAZ
wnt ligand:
WNT1 WNT10A WNT10B WNT11 WNT16 WNT2 WNT2B WNT3 WNT3A WNT4 WNT5A WNT5B WNT6 WNT7A WNT7B WNT8A WNT8B WNT9A WNT9B
other regulator:
ABL1 ARRB1 ATF2 CCNB1 CD40 CDK1 DLG4 F2R FAS FASLG GIPC2 GOPC IFNG IGF1 IGF1R IGF2 IGF2R IL6 IL6R INHBB MAGI3 NCSTN NDP NODAL PDGFA PDGFB PDGFC PDGFD PDGFRA PDGFRB PRKCA PRKCB PRKCD PRKCG PRKCH PRKCI PRKCQ PRKCZ PRKD3 PSEN1 PSEN2 RBPJ SIN3A SMAD1 SMAD5 SMAD6 SMAD7 SMAD9 SMURF1 SMURF2 SNW1 TGFB1 TGFB2 TGFB3 TGFBR1 TGFBR2 TGFBR3 TGFBRAP1
target Development & Differentiation:
ANGPTL4 CTGF EGR1 GDF5 GDNF SIX1 T
negtive regulator:
AES ANKRD6 APCDD1 BTRC CACYBP CAV1 CBY1 CER1 CSNK1A1 CSNK1A1L CSNK2B CTBP1 CTBP2 CTNNBIP1 CUL3 CXXC4 DACT1 DDX5 DKK1 DKK2 DKK3 DKK4 DLG1 DLG2 DLG3 DLG4 DLG5 FBXW11 FHIT FOXO1 FOXO3 FOXO4 FRZB GLI1 GLI2 GLI3 HBP1 HDAC1 HDAC10 HDAC11 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 IGFBP4 INVS KIF3A KLF4 KLHL12 MAP2K1 MAP3K7 MESDC2 NEK2 NFKB1 NFKB2 NKD1 NKD2 NLK PPP2R3A PPP2R5A PRICKLE1 PRICKLE2 PRICKLE3 PRICKLE4 PROP1 PSEN1 PTEN PTK2B RANBP3 SENP2 SFRP1 SFRP2 SFRP4 SFRP5 SHISA2 SHISA3 SHISA4 SIAH1 SIRT1 SKP1 SOST SOX13 SOX17 SOX2 SOX7 SOX9 SUFU TBL1X TCF4 TLE1 TLE2 TLE3 TLE4 TLE6 TNKS VHL WIF1 YWHAQ ZAK ZIC2
TF:
LEF1 TCF7 TCF7L1 TCF7L2
Planar Cell Polarity (PCP):
DAAM1 MAPK8 RHOA VANGL2
POSITIVE FEEDBACK:
FZD7 LEF1 LGR5 MET
WNT Signaling Pathway:
AES APC AXIN1 AXIN2 BCL9 BTRC CCND1 CCND2 CSNK1A1 CSNK2A1 CTBP1 CTNNB1 CTNNBIP1 CXXC4 DAAM1 DAB2 DIXDC1 DKK1 DKK3 DVL1 DVL2 EP300 FBXW11 FBXW4 FGF4 FOSL1 FOXN1 FRAT1 FRZB FZD1 FZD2 FZD3 FZD4 FZD5 FZD6 FZD7 FZD8 FZD9 GSK3A GSK3B JUN KREMEN1 LEF1 LRP5 LRP6 MAPK8 MMP7 MYC NFATC1 NKD1 NLK PITX2 PORCN PPARD PRICKLE1 PYGO1 RHOA RHOU RUVBL1 SFRP1 SFRP4 SOX17 TCF7 TCF7L1 TLE1 VANGL2 WIF1 WISP1 WNT1 WNT10A WNT11 WNT16 WNT2 WNT2B WNT3 WNT3A WNT4 WNT5A WNT5B WNT6 WNT7A WNT7B WNT8A WNT9A
WNT/Ca 2:
NFATC1
positive regulator:
AGGF1 AKT1 ALYREF AR ARRB2 BCL9 CDC73 CDK8 CREBBP CSNK1D CSNK1E CSNK1G1 CSNK1G2 CSNK1G3 CSNK2A1 CSNK2A2 DDX5 EP300 FER FRAT1 FRAT2 FYN GAS1 GRB2 HGF ILK KRAS LGR4 LGR5 MACF1 MAPK1 MAPK11 MAPK13 MAPK14 MAPK6 MAPK7 MAPK9 MARK2 MDFIC MED12 MET MITF PAF1 PIAS4 PIK3CA PIK3CB PIK3CD PIK3CG PIN1 PPA1 PPM1A PPM1B PPM1D PPM1G PPM1J PPM1K PPM1L PPM1M PPP2CA PPP2R1A PPP2R2B PPP2R4 PRKACA PRKACB PRKACG PRKAR1A PRKCB PRKCZ PYGO1 PYGO2 RPS6KA3 RPS6KB1 RSPO1 RSPO2 RUVBL1 RUVBL2 SHC1 SMAD2 SMAD3 SMAD4 SMARCA4 SOS1 SOS2 SOX4 SRC SRF TNIK TSPAN12 YWHAZ
NEGATIVE FEEDBACK:
AXIN2 DKK1 NKD1 NKD2 SFRP2
TARGET:
ABCB1 ACTG1 ADAM10 ASCL1 ATOH1 AXIN2 BGLAP BIRC5 BMP4 BSG BTG3 CACNA1G CALD1 CCND1 CCND2 CCND3 CD44 CDH1 CDKN1A CDKN2A CDX1 CDX4 CLDN7 CTLA4 CUL2 CXCL1 CXCR2 CYR61 DKK1 DLK1 DLL1 DLL3 DLL4 E2F1 EDA EDN1 EFNB1 EFNB2 EGF EGFR EMP1 EN2 ENC1 ENPP2 EPHB2 FGF18 FGF20 FGF4 FGF9 FGFR1 FGFR2 FN1 FOSL1 FOXN1 FST FZD7 GAP43 GAST GBX2 GJA5 GJB6 GREM1 HMGN1 HNF1A HRAS HSPA5 IBSP IFI30 IGF1 IGF2 IL32 IL6 INS IRX3 ISL1 ISLR JAG1 JUN KLF5 KRT14 KRT18 KRT5 KRT8 L1CAM LBH LEF1 LGR5 MAEA MAP4K2 MET MMP2 MMP26 MMP3 MMP7 MMP9 MSL1 MUC2 MYB MYC MYCBP MYCN MYF6 NANOG NEUROD1 NEUROG1 NKD1 NKD2 NKX2-2 NONO NOS2 NRCAM OVOL1 PDCL PITX2 PLAUR POSTN POU5F1 PPARD PSMA6 PTGS2 PTTG1 PXN RAB14 RARG RHOB RHOU RUNX2 SALL4 SDC2 SFRP2 SIX3 SLC9A3R1 SNAI1 SNX9 SOX17 SOX2 SOX9 SP5 SPP1 STRA6 TBX1 TCF4 TEP1 TIAM1 TJP1 TNF TNFRSF11A TNFRSF11B TNFRSF19 TNFRSF4 TNFRSF9 TWIST1 UBXN1 VCAN VCL VEGFA VEGFC WISP1 WISP2 WNT3A
Wnt Signaling:
AES APC APC2 AXIN1 AXIN2 BCL9 CCND1 CCND2 CCND3 CER1 CHD8 CREBBP CSNK1A1 CSNK1A1L CSNK1E CSNK2A1 CSNK2A2 CSNK2B CTBP1 CTBP2 CTNNB1 CTNNBIP1 CXXC4 DKK1 DKK2 DKK4 DVL1 DVL2 DVL3 EP300 FOSL1 FRAT1 FRAT2 FZD1 FZD10 FZD2 FZD3 FZD4 FZD5 FZD6 FZD7 FZD8 FZD9 GSK3B JUN KREMEN1 KREMEN2 LEF1 LRP5 LRP6 MMP7 MYC NKD1 NKD2 NLK PORCN PPARD PPP2CA PPP2R1A PYGO1 RUVBL1 RYK SENP2 SFRP1 SFRP2 SFRP4 SFRP5 SMAD2 SMAD3 SMAD4 SOX17 TCF7 TCF7L1 TCF7L2 TLE1 TLE2 WIF1 WNT1 WNT10A WNT10B WNT11 WNT16 WNT2 WNT2B WNT3 WNT3A WNT4 WNT5A WNT5B WNT6 WNT7A WNT7B WNT8A WNT8B WNT9A WNT9B
SIGNAL:
APC APC2 AXIN1 AXIN2 CSNK1A1 CTNNB1 DKK1 DKK2 DKK3 DKK4 DVL1 DVL2 DVL3 GSK3A GSK3B PORCN WLS
Migration:
CTGF FGF7 GDNF IRS1 NRP1 PPAP2B SIX1
Proteolysis:
DPP10
target transcription factors:
AHR CEBPD EGR1 ETS2 SIX1 T
Canonical:
SKP2

LncRNA List
The mouse Wnt pathway LncRNAs are listed in Table 1. Click the LncRNA accession numbers to see the detailed information about the LncRNAs and their potential coding gene targets in the Wnt pathway.

Table 1. Mouse WNT pathway focused LncRNAs

ENSMUST00000067277, ENSMUST00000082225, ENSMUST00000091324, ENSMUST00000092369, ENSMUST00000105060, ENSMUST00000117520, ENSMUST00000117856, ENSMUST00000117905, ENSMUST00000118819, ENSMUST00000119038, ENSMUST00000119460, ENSMUST00000120814, ENSMUST00000121015, ENSMUST00000121061, ENSMUST00000122308, ENSMUST00000122923, ENSMUST00000123273, ENSMUST00000124166, ENSMUST00000124315, ENSMUST00000124439, ENSMUST00000124577, ENSMUST00000125440, ENSMUST00000125567, ENSMUST00000126472, ENSMUST00000127059, ENSMUST00000127079, ENSMUST00000127174, ENSMUST00000128182, ENSMUST00000128654, ENSMUST00000129200, ENSMUST00000129527, ENSMUST00000129675, ENSMUST00000130409, ENSMUST00000130520, ENSMUST00000131456, ENSMUST00000131533, ENSMUST00000132340, ENSMUST00000132535, ENSMUST00000133376, ENSMUST00000133528, 

Full List of Mouse Wnt Pathway Focused LncRNAs.pdf

Gene List
The potential gene targets of the mouse WNT pathway focus LncRNAs are listed in Table 2. Click the protein gene names to see the detailed information about the genes and their corresponding regulatory LncRNAs in the WNT pathway.

Table 2. Functional gene grouping

target relevant Signaling Pathways:
Gdf5 Id2 Lrp1 Ppap2b Ptch1
Adhesion:
Ctgf
WNT RECEPTORS:
Fzd1 Fzd10 Fzd2 Fzd3 Fzd4 Fzd5 Fzd6 Fzd7 Fzd8 Fzd9 Kremen1 Kremen2 Ldlr Lrp5 Lrp6 Ryk Smo
Cell Cycle:
Ahr Id2
WNT Signaling Targets:
Abcb1a Ahr Angptl4 Antxr1 Axin2 Birc5 Bmp4 Btrc Cacna2d3 Ccnd1 Ccnd2 Cd44 Cdh1 Cdkn2a Cdon Cebpd Ctgf Cubn Dab2 Dkk1 Dlk1 Dpp10 Efnb1 Egfr Egr1 Ets2 Fgf20 Fgf4 Fgf7 Fgf9 Fn1 Fosl1 Fst Fzd7 Gdf5 Gdnf Gja1 Id2 Igf1 Igf2 Il6 Irs1 Jag1 Klf5 Lef1 Lrp1 Met Mmp2 Mmp7 Mmp9 Myc Nanog Nrcam Nrp1 Ntrk2 Pdgfra Pitx2 Plaur Pou5f1 Ppap2b Ppard Ptch1 Ptgs2 Runx2 Sfrp2 Six1 Smo Sox2 Sox9 T Tcf4 Tcf7 Tcf7l1 Tcf7l2 Tgfb3 Tle1 Twist1 Vegfa Wisp1 Wisp2 Wnt3a Wnt5a Wnt9a
oncogene:
Bcl9 Cdx1 Ctnnb1 Cxcl3 Egfr Fert2 Fgf4 Fgfr1 Fgfr2 Fosl1 Frat1 Frat2 Fyn Gli1 Gli2 Gli3 Gopc Hgf Hras1 Jun Kras Krt14 Maea Mitf Mmp7 Myb Myc Mycn Pdgfb Pik3cg Plaur Prkci Pttg1 Rab14 Runx2 Sos1 Src Tiam1 Wnt1 Wnt10b Wnt3 Wnt7a
Calcium Binding and Signaling:
Cacna2d3 Cubn Lrp1
tumor suppressor:
Abcb1a Abl1 Akt1 Apc Ar Arrb2 Axin1 Axin2 Birc5 Bsg Btg3 Btrc Cav1 Cby1 Ccnd1 Ccnd2 Ccnd3 Cdc73 Cdh1 Cdkn1a Cdkn2a Crebbp Cul2 Cyr61 Ddx5 Dkk1 Dkk3 Dlg3 Dlk1 E2f1 Edn1 Enc1 Ephb2 Fas Fhit Foxo1 Foxo3 Gas1 Gsk3b Hbp1 Hdac1 Hdac2 Hdac3 Ifng Igf1 Igf1r Igf2r Igfbp4 Il6 Klf4 Klf5 Map3k7 Mapk1 Mapk14 Mapk9 Met Mmp2 Nfkb1 Nfkb2 Pik3ca Ppard Ppm1a Ppm1d Ppm1l Ppp2r2b Prickle1 Prkar1a Prkcd Pten Ptgs2 Rarg Rhob Sdc2 Sfrp1 Sfrp2 Sfrp4 Sfrp5 Siah1a Sirt1 Slc9a3r1 Smad2 Smad3 Smad4 Smad5 Smarca4 Smo Sox4 Sox7 Spp1 Sufu Tcf4 Tcf7 Tgfb1 Tjp1 Tnf Vhl Wif1 Wnt5a Ywhaq Ywhaz
wnt ligand:
Wnt1 Wnt10a Wnt10b Wnt11 Wnt16 Wnt2 Wnt2b Wnt3 Wnt3a Wnt4 Wnt5a Wnt5b Wnt6 Wnt7a Wnt7b Wnt8a Wnt8b Wnt9a Wnt9b
other regulator:
Abl1 Arrb1 Atf2 Cd40 Cdk1 Dlg4 F2r Fas Fasl Gipc2 Gopc Ifng Igf1 Igf1r Igf2 Igf2r Il6 Il6ra Inhbb Magi3 Ncstn Ndp Nodal Pdgfa Pdgfb Pdgfc Pdgfd Pdgfra Pdgfrb Prkca Prkcb Prkcd Prkcg Prkch Prkci Prkcq Prkcz Prkd3 Psen1 Psen2 Rbpj Sin3a Smad1 Smad5 Smad6 Smad7 Smad9 Smurf1 Smurf2 Snw1 Tgfb1 Tgfb2 Tgfb3 Tgfbr1 Tgfbr2 Tgfbr3 Tgfbrap1
target Development & Differentiation:
Angptl4 Ctgf Egr1 Gdf5 Gdnf Six1 T
negtive regulator:
Aes Ankrd6 Apcdd1 Btrc Cacybp Cav1 Cby1 Cer1 Csnk1a1 Csnk2b Ctbp1 Ctbp2 Ctnnbip1 Cul3 Cxxc4 Dact1 Ddx5 Dkk1 Dkk2 Dkk3 Dkk4 Dlg1 Dlg2 Dlg3 Dlg4 Dlg5 Fbxw11 Fhit Foxo1 Foxo3 Foxo4 Frzb Gli1 Gli2 Gli3 Hbp1 Hdac1 Hdac10 Hdac11 Hdac2 Hdac3 Hdac4 Hdac5 Hdac6 Hdac7 Hdac8 Igfbp4 Invs Kif3a Klf4 Klhl12 Map2k1 Map3k7 Mesdc2 Nek2 Nfkb1 Nfkb2 Nkd1 Nkd2 Nlk Ppp2r3a Ppp2r5a Prickle1 Prickle2 Prickle3 Prickle4 Prop1 Psen1 Pten Ptk2b Ranbp3 Senp2 Sfrp1 Sfrp2 Sfrp4 Sfrp5 Shisa2 Shisa3 Shisa4 Siah1a Sirt1 Skp1a Sost Sox13 Sox17 Sox2 Sox7 Sox9 Sufu Tbl1x Tcf4 Tle1 Tle2 Tle3 Tle4 Tle6 Tnks Vhl Wif1 Ywhaq Zic2
TF:
Lef1 Tcf7 Tcf7l1 Tcf7l2
Planar Cell Polarity (PCP):
Daam1 Mapk8 Rhoa Vangl2
POSITIVE FEEDBACK:
Fzd7 Lef1 Lgr5 Met
WNT Signaling Pathway:
Aes Apc Axin1 Axin2 Bcl9 Btrc Ccnd1 Ccnd2 Csnk1a1 Csnk2a1 Ctbp1 Ctnnb1 Ctnnbip1 Cxxc4 Daam1 Dab2 Dixdc1 Dkk1 Dkk3 Dvl1 Dvl2 Ep300 Fbxw11 Fbxw4 Fgf4 Fosl1 Foxn1 Frat1 Frzb Fzd1 Fzd2 Fzd3 Fzd4 Fzd5 Fzd6 Fzd7 Fzd8 Fzd9 Gsk3a Gsk3b Jun Kremen1 Lef1 Lrp5 Lrp6 Mapk8 Mmp7 Myc Nfatc1 Nkd1 Nlk Pitx2 Porcn Ppard Prickle1 Pygo1 Rhoa Rhou Ruvbl1 Sfrp1 Sfrp4 Sox17 Tcf7 Tcf7l1 Tle1 Vangl2 Wif1 Wisp1 Wnt1 Wnt10a Wnt11 Wnt16 Wnt2 Wnt2b Wnt3 Wnt3a Wnt4 Wnt5a Wnt5b Wnt6 Wnt7a Wnt7b Wnt8a Wnt9a
WNT/Ca 2:
Nfatc1
positive regulator:
Aggf1 Akt1 Alyref Ar Arrb2 Bcl9 Cdc73 Cdk8 Crebbp Csnk1d Csnk1e Csnk1g1 Csnk1g2 Csnk1g3 Csnk2a1 Csnk2a2 Ddx5 Ep300 Fert2 Frat1 Frat2 Fyn Gas1 Grb2 Hgf Ilk Kras Lgr4 Lgr5 Mapk1 Mapk11 Mapk13 Mapk14 Mapk6 Mapk7 Mapk9 Mark2 Mdfic Med12 Met Mitf Paf1 Pias4 Pik3ca Pik3cb Pik3cd Pik3cg Pin1 Ppa1 Ppm1a Ppm1b Ppm1d Ppm1g Ppm1j Ppm1k Ppm1l Ppm1m Ppp2ca Ppp2r1a Ppp2r2b Ppp2r4 Prkaca Prkacb Prkar1a Prkcb Prkcz Pygo1 Pygo2 Rps6ka3 Rps6kb1 Rspo1 Rspo2 Ruvbl1 Ruvbl2 Shc1 Smad2 Smad3 Smad4 Smarca4 Sos1 Sos2 Sox4 Src Srf Tnik Tspan12 Ywhaz
NEGATIVE FEEDBACK:
Axin2 Dkk1 Nkd1 Nkd2 Sfrp2
TARGET:
Abcb1a Actg1 Adam10 Ascl1 Atoh1 Axin2 Birc5 Bmp4 Bsg Btg3 Cacna1g Ccnd1 Ccnd2 Ccnd3 Cd44 Cdh1 Cdkn1a Cdkn2a Cdx1 Cdx4 Cldn7 Ctla4 Cul2 Cxcl3 Cxcr2 Cyr61 Dkk1 Dlk1 Dll1 Dll3 Dll4 E2f1 Eda Edn1 Efnb1 Efnb2 Egf Egfr Emp1 En2 Enc1 Enpp2 Ephb2 Fgf18 Fgf20 Fgf4 Fgf9 Fgfr1 Fgfr2 Fn1 Fosl1 Foxn1 Fst Fzd7 Gap43 Gast Gbx2 Gja5 Gjb6 Grem1 Hnf1a Hras1 Hspa5 Ibsp Ifi30 Igf1 Igf2 Il6 Ins2 Irx3 Isl1 Islr Jag1 Jun Klf5 Krt14 Krt18 Krt5 Krt8 L1cam Lbh Lef1 Lgr5 Maea Map4k2 Met Mmp2 Mmp3 Mmp7 Mmp9 Msl1 Myb Myc Mycbp Mycn Myf6 Nanog Neurod1 Neurog1 Nkd1 Nkd2 Nkx2-2 Nono Nos2 Nrcam Ovol1 Pdcl Pitx2 Plaur Postn Pou5f1 Ppard Psma6 Ptgs2 Pttg1 Pxn Rab14 Rarg Rhob Rhou Runx2 Sall4 Sdc2 Sfrp2 Six3 Slc9a3r1 Snai1 Snx9 Sox17 Sox2 Sox9 Sp5 Spp1 Stra6 Tbx1 Tcf4 Tep1 Tiam1 Tjp1 Tnf Tnfrsf11a Tnfrsf11b Tnfrsf19 Tnfrsf4 Tnfrsf9 Twist1 Ubxn1 Vcan Vcl Vegfa Vegfc Wisp1 Wisp2 Wnt3a
Wnt Signaling:
Aes Apc Apc2 Axin1 Axin2 Bcl9 Ccnd1 Ccnd2 Ccnd3 Cer1 Chd8 Crebbp Csnk1a1 Csnk1e Csnk2a1 Csnk2a2 Csnk2b Ctbp1 Ctbp2 Ctnnb1 Ctnnbip1 Cxxc4 Dkk1 Dkk2 Dkk4 Dvl1 Dvl2 Dvl3 Ep300 Fosl1 Frat1 Frat2 Fzd1 Fzd10 Fzd2 Fzd3 Fzd4 Fzd5 Fzd6 Fzd7 Fzd8 Fzd9 Gsk3b Jun Kremen1 Kremen2 Lef1 Lrp5 Lrp6 Mmp7 Myc Nkd1 Nkd2 Nlk Porcn Ppard Ppp2ca Ppp2r1a Pygo1 Ruvbl1 Ryk Senp2 Sfrp1 Sfrp2 Sfrp4 Sfrp5 Smad2 Smad3 Smad4 Sox17 Tcf7 Tcf7l1 Tcf7l2 Tle1 Tle2 Wif1 Wnt1 Wnt10a Wnt10b Wnt11 Wnt16 Wnt2 Wnt2b Wnt3 Wnt3a Wnt4 Wnt5a Wnt5b Wnt6 Wnt7a Wnt7b Wnt8a Wnt8b Wnt9a Wnt9b
SIGNAL:
Apc Apc2 Axin1 Axin2 Csnk1a1 Ctnnb1 Dkk1 Dkk2 Dkk3 Dkk4 Dvl1 Dvl2 Dvl3 Gsk3a Gsk3b Porcn Wls
Migration:
Ctgf Fgf7 Gdnf Irs1 Nrp1 Ppap2b Six1
Proteolysis:
Dpp10
target transcription factors:
Ahr Cebpd Egr1 Ets2 Six1 T
Canonical:
Skp2