The Wnt pathway is important in tumorigenesis and developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division [1, 2].
The LncPath™ Human Wnt Pathway LncRNA Microarray simultaneously profiles the expression of 1,317 LncRNAs and 476 of the potential coding genes related to the Wnt signaling pathway. The LncPath™ Mouse Wnt Pathway LncRNA Microarray simultaneously profiles the expression of 1,033 LncRNAs and 808 of the potential coding genes related to the Wnt signaling pathway. Using this array, scientists can leverage the pre-designed panel as a powerful tool to quickly generate expression data for both the lncRNAs and their potential coding gene targets in the Wnt signaling pathway, while gaining comprehensive insights into the underlying regulatory mechanisms of LncRNAs in the Wnt pathway.
• Reliable Wnt pathway focus LncRNA collection
• Simultaneous analysis of LncRNAs and their potential coding gene targets related to the Wnt pathway
• Efficient and robust labeling system
• Innovative probe design
• Guaranteed performance
An example of the figures showing the detailed information about the LncRNAs and their potential coding gene targets
Click the LncRNA accession number listed in databases, you will see the figures showing the detailed information about the LncRNAs and their potential target gene.
Figure 1. The genomic map views of the LncRNA ENST00000450624 and its potential target gene ABCB1. From the top to the bottom of the figure 1, the following items are demonstrated:
Genome view: A chromosome ideogram showing the map position of the LncRNA ENST00000450624 and its potential target gene ABCB1(red bar).
Map view ruler: The map coordinates of the human genome assembly hg19 for the map views below.
LncRNA map view: The LncRNAs whose genes located at or near the ABCB1 gene are presented in the Noncoding panel (shaded blue). The LncRNAs are indicated by the transcript IDs, the exons by solid blocks, the introns by thin lines, and the transcription directions by arrows. The exons of LncRNA ENST00000450624 are labeled in red, while the exons of the other LncRNAs are labeled in blue.
Coding gene map view: The coding gene ABCB1 is presented in the Coding panel (shaded green). The coding gene is indicated by its canonical transcript ID, the exons by solid blocks, the introns by thin lines, and the transcription direction by arrows.
Figure 2. The relationship between LncRNA ENST00000450624 and its protein coding gene target ABCB1. The other neighboring LncRNAs which may regulate ABCB1 expression are also shown.
Figure 3. The LncRNA ENST00000498734 may function as a competing endogenous RNA (ceRNA) of the protein coding gene ABCB1.
* MuTaMe Score, Mutually Targeted MRE Enrichment Score .
References1. Anastas, J.N. and R.T. Moon, WNT signalling pathways as therapeutic targets in cancer. Nat Rev Cancer, 2013. 13(1): p. 11-26.
2. Saito-Diaz, K., et al., The way Wnt works: components and mechanism. Growth Factors, 2013. 31(1): p. 1-31.
3. Tay, Y., et al., Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs. Cell, 2011. 147(2): p. 344-57.