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  • Human Database
  • Mouse Database
Product NameCatalog NoDescriptionFormatPrice
LncPath™ Human Neurodegenerative Disease Microarray AS-LP-008H 1,168 LncRNAs and 510 potential coding targets 8*15K
LncPath™ Mouse Neurodegenerative Disease Microarray AS-LP-008M 749 LncRNAs and 888 their potential coding targets 8*15K

Neurodegenerative disorders are often accompanied by widespread changes in gene regulatory networks. Recent studies have found that these changes are not restricted to protein-coding genes, but also include long non-coding RNAs (LncRNAs). Accumulating evidences have shown that LncRNAs are widely expressed in the mammalian nervous system, and the aberrant expression of LncRNAs is implicated in neurodegenerative diseases, including Alzheimer’s (AD) and Huntington’s disease (HD). However, the functional roles of LncRNAs and their underlying regulatory mechanisms in neurodegenerative diseases are still largely unknown.

The LncPath™ Human Neurodegenerative Disease Array simultaneously profiles the expression of 1,168 LncRNAs and 510 their potential coding targets related to the cardiovascular pathologies. The LncPath™ Mouse Neurodegenerative Disease Array simultaneously profiles the expression of 749 LncRNAs and 888 their potential coding targets related to the cardiovascular pathologies. The LncRNAs whose gene loci are located at or near the protein-coding genes critical in cardiovascular disease pathways, and LncRNAs which have high possibility as the potential ceRNA of the key genes involved in cardiovascular pathologies, are carefully selected from authoritative databases by using a rigorous process. By limiting the number of LncRNAs most relevant to cardiovascular diseases, this array can achieve much faster analysis with greater precision due to the highly specific, yet smaller amount of data to analyze. More importantly, it can establish the expression relationship between LncRNAs and their potential protein-coding targets involved in the cardiovascular diseases, thereby providing comprehensive insights into the underlying regulatory mechanisms of LncRNAs in cardiovascular pathologies.

• Reliable neurodegenerative disease focus LncRNA collection

• Simultaneous analysis of LncRNAs and their potential coding gene targets related to the neurodegenerative diseases.

• Efficient and robust labeling system

• Innovative probe design

• Guaranteed performance

An example showing the detailed information about the LncRNAs and their potential coding gene target

Click the LncRNA accession number listed in databases, you will see the figures showing the detailed information about the LncRNAs and their potential target gene.

ABCA1
Figure 1. The genomic map views of the LncRNA ENST00000435915 and its potential target gene ABCA1. From the top to the bottom of the figure 1, the following items are displayed:

Genome view: A chromosome ideogram showing the map position of the LncRNA ENST00000435915 and its potential target gene ABCA1(red bar).

Map view ruler: The map coordinates of the human genome assembly hg19 for the map views below.

LncRNA map view: The LncRNAs whose genes located at or near the ABCA1 gene are presented in the Noncoding panel (shaded green). The LncRNAs are indicated by the transcript IDs, the exons by solid blocks, the introns by thin lines, and the transcription directions by arrows. The exons of LncRNA ENST00000435915 are labeled in red, while the exons of the other LncRNAs are labeled in blue.

Coding gene map view: The coding gene ABCA1 is presented in the Coding panel (shaded blue). The coding gene is indicated by its canonical transcript ID, the exons by solid blocks, the introns by thin lines, and the transcription direction by arrows.

ABCA1-2

Figure 2. The relationship between LncRNA ENST00000435915 and its protein coding gene target ABCA1. The other neighboring LncRNAs which may regulate ABCA1 expression are also shown.

ABCA1-3
Figure 3. The LncRNA ENST00000534271 may function as a competing endogenous RNA (ceRNA) of the protein coding gene ABCA1.

* MuTaMe Score, Mutually Targeted MRE Enrichment Score [1].

References

1.Tay, Y., et al., Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs. Cell, 2011. 147(2): p. 344-57.

LncRNA List

The human neurodegenerative disease focused LncRNAs are listed in Table 1. Click the LncRNA accession numbers to see the detailed information about the LncRNAs and their potential coding gene targets in neurodegenerative diseases.

Table 1. Human Neurodegenerative disease focused LncRNAs

ENST00000279573, ENST00000314232, ENST00000331871, ENST00000333854, ENST00000366413, ENST00000367269, ENST00000369391, ENST00000374207, ENST00000377176, ENST00000382133, ENST00000398357, ENST00000400619, ENST00000402520, ENST00000404127, ENST00000411629, ENST00000411754, ENST00000412067, ENST00000412173, ENST00000412228, ENST00000412387, ENST00000412804, ENST00000412812, ENST00000412951, ENST00000412972, ENST00000413053, ENST00000413234, ENST00000413320, ENST00000413334, ENST00000413501, ENST00000413578, ENST00000414397, ENST00000414920, ENST00000415054, ENST00000415890, ENST00000416146, ENST00000416302, ENST00000416432, ENST00000416689, ENST00000417820, ENST00000418138, ENST00000418292, ENST00000418418, ENST00000418850, ENST00000419535, ENST00000420253, ENST00000420480, ENST00000420492, ENST00000420537, ENST00000421143, ENST00000421637, 

Full List of Human Neurodegenerative Disease Related LncRNAs.pdf

Gene List

The potential gene targets of human neurodegenerative disease focused LncRNAs are listed in Table 2. Click the protein gene names to see the detailed information about the genes and their corresponding regulatory LncRNAs in the neurodegenerative diseases.

Table 2. Functional gene grouping

GABAergic:
DRD2 GABBR2
Genes Involved in Autophagic Vacuole Formation:
AMBRA1 ATG12 ATG16L1 ATG4A ATG4B ATG4C ATG4D ATG5 ATG9A ATG9B BECN1 GABARAP GABARAPL1 GABARAPL2 IRGM MAP1LC3A MAP1LC3B RGS19 ULK1 WIPI1
Chaperone-Mediated Autophagy:
HSP90AA1 HSPA8
Membrane Polarization & Potential:
BAK1 BCL2 BCL2L1 BNIP3 SOD1 TP53 UCP1 UCP2 UCP3
Transcription:
APBB1 APBB2 EP300 ERN1
Dopaminergic:
NSG1 DDC DRD2 HTR2A NR4A2 PARK2 PARK7 PINK1 SEPT5 SLC6A3 SNCA TH
Other Genes:
A2M ACHE APBB1 APBB2 APOE BCHE UBQLN1 GAP43 GNB2 IDE IL1A INSR NAE1 PLAU
Mitochondrial Transport:
AIP BAK1 BCL2 BCL2L1 BNIP3 CPT1B CPT2 GRPEL1 HSP90AA1 HSPD1 IMMP2L MFN2 MIPEP MTX2 STARD3 TP53 TSPO UCP1 UCP2 UCP3
Pro-Apoptosis:
APC APP CASP1 CASP3 CASP8 CASP9 CUL2 MAPK9 PSEN2 PTEN
Huntingtin Cofactors:
CLTC CREBBP DCTN1 DLG4 EGFR GRB2 HAP1 HDAC2 HIP1 MAP3K10 NCOR1 PACSIN1 PRPF40A PTPN11 RCOR1 REST SIN3A SP1 SYMPK TBP TP53
Heat Shock Proteins/Unfolded Protein Response:
ATF4 ATF6 ATF6B BBC3 BID CALR DDIT3 DNAJC3 HSP90AA1 HSP90B1 HSPA4 HSPA5
Genes with Protease Activity:
ATG4A ATG4B ATG4C ATG4D
Regulation of Cholesterol Metabolism:
INSIG2 MBTPS1 MBTPS2 SCAP SREBF1
Cell Cycle:
APBB1 APBB2 CDK1 CDK5 CDKL1 EP300 ERN1 IL1A NAE1 PRKCA
Inflammation:
FN1 PRDX2 YWHAZ
Regulation of Translation:
EIF2A EIF2AK3 PPP1R15A SERP1
Pathway Activity Signature Genes:
ADM2 ASNS BEX2 DDIT3 DNAJB9 GINS2 HERPUD1 INHBE KCNMB3 MCM4 PCNA RRM2 SLC17A2 TRIB3 TYMS UHRF1
Transcription Factors:
ATF4 ATF6 ATF6B ATXN3 CALR CEBPB CREB3 CREB3L3 DDIT3 ERN1 ERN2 MBTPS1 PFDN5 SCAP SREBF1 XBP1
Inflammatory Response:
CCL2 CD40LG CRP IFNG IL1A IL1B IL6 IL8 TLR4 TNF
Unfolded Protein Binding:
CALR CANX CCT4 DNAJB9 DNAJC10 ERO1LB HSPA1B HSPA2 HTRA2 PFDN5 PPIA SCAP SEC63 SIL1 TCP1 TOR1A UGGT1
Heat Shock Proteins:
DNAJB9 DNAJC10 DNAJC3 HSPA4 HSPA5 HSPH1 SEC63
Intracellular Signaling:
APBA3 APBB2 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCI PRKCQ PRKCZ PSEN1 PSEN2
Secretases:
ADAM9 APH1A BACE1 BACE2 CTSB NCSTN PSEN1 PSEN2
Targeting Proteins to Mitochondria:
AIP GRPEL1 HSPD1 IMMP2L MFN2 MIPEP TSPO
Hypoxia:
ADM ARNT BNIP3L CA9 EPO HMOX1 LDHA MMP9 SERPINE1 SLC2A1 VEGFA
Co-Regulators of Autophagy and the Cell Cycle:
BAX CDKN1B CDKN2A IFNG PTEN RB1 TGFB1 TP53
Synaptic Vesicles:
LRRK2 SEPT5 SV2B SYNGR3 SYT1 SYT11 TH
Apoptosis:
APLP1 APP CASP3 CASP4 CLU EP300 ERN1 IL1A MAPT MPO NAE1 PRKCA PRKCE PRKCZ PSEN1 PSEN2 SNCA AKT1 APOE BAX BDNF CASP3 CASP8 CD44 CREB1 EEF1A2 EGFR ELMO1 GJB6 GRIN2A HIP1 HTT IFT57 IGF1 MAP3K10 NEFL NGEF SGK1 SLC25A4 SOX2 TBP TP53 TUBB ZBTB16 CASP1 FAS MCL1 TNFRSF10A TNFRSF10B TNFRSF1A ATXN3 BAX CALR CEBPB DDIT3 EIF2AK3 ERN1 ERN2 HSPA1B HTRA2 MANF MAPK8 MAPK9 PDIA3 PPP1R15A VIMP VCP
G-protein Coupled Receptor Signaling:
APLP2 GNAO1 GNAZ GNB1 GNB4 GNB5 GNG11 GNG3 GNG4 GNGT1 GNGT2 NTRK1 NTRK2
Oxidation/Reduction:
APOE BBOX1 EGFR GPX1 KCNAB1 KCNAB2 PLOD2 PPARGC1A SOD1
Ion Transport:
ATP2B2 CADPS CXXC1 DRD2 EGLN1 GBE1 GRIA3 HTR2A KCNJ6 NSF PSEN2 S100B SLIT1 SNCA SRSF7 VDAC3 AKT1 AQP1 ATP2B2 GABRD GRIN2A HOMER1 HTT ITPR1 KCNAB1 KCNAB2 KCNC3 PPP3CA SGK1
Notch Signaling:
ADAM10 APH1A NCSTN PSEN1 PSEN2
Cytoskeletal Organization:
APC CDC42 MAPT NEFL PARK2
Oxidative Stress:
HSD17B10 MPO UQCRC1 UQCRC2 FTH1 GCLC GCLM GSR GSTP1 HMOX1 NQO1 PRDX1 SQSTM1 TXN TXNRD1
Genes Involved in Protein Ubiquitination:
ATG3 ATG7 HDAC6
Others:
ALDH1A1 BASP1 CHGB DLK1 NCOA1 NTRK2 RTN1 PGK1 RGS4 SLC14A1
Osmotic Stress:
AKR1B1 AQP1 AQP2 AQP4 CFTR EDN1 HSPA4L NFAT5 SLC5A3
Cytoskeleton Organization:
APOE ARFIP2 ELMO1 NCOR1 NEFL PACSIN1 TAC1 TUBB
Co-Regulators of Autophagy and Apoptosis:
AKT1 APP ATG12 ATG5 BAD BAK1 BAX BCL2 BCL2L1 BECN1 BID BNIP3 CASP3 CASP8 CDKN1B CDKN2A CLN3 CTSB CXCR4 DAPK1 DRAM1 EIF2AK3 FADD FAS HDAC1 HTT IFNG IGF1 INS MAPK8 MTOR NFKB1 PIK3CG PRKAA1 PTEN SNCA SQSTM1 TGFB1 TGM2 TNF TNFSF10 TP53
Inner Membrane Translocation:
IMMP1L IMMP2L OPA1 TAZ TIMM10 TIMM17A TIMM17B TIMM22 TIMM23 TIMM44 TIMM50 TIMM8A TIMM8B TIMM9
Transcription Factor Targets REST:
BDNF CALB1 DLG4 EEF1A2 ELMO1 FGF12 GABRD GRIN2A KCNAB2 KCNC3 NEFL RPH3A RXRB SNAP25 SYN1 TOLLIP TUBB
Ubiquitination:
CDC27 CUL2 FBXO9 LRRK2 PAN2 PARK2 PINK1 SKP1 STUB1 UBA1 UBB UBE2I UBE2K UBE2L3 UCHL1 USP34 AMFR HERPUD1 RNF5 SEC62 SEL1L UBE2G2 UBXN4 UFD1L USP14 VCP
ER Associated Degradation (ERAD):
AMFR DERL1 EDEM1 FBXO6 HERPUD1 HTRA2 HTRA4 MBTPS1 MBTPS2 NPLOC4 NUCB1 OS9 SEC62 SEL1L VIMP SYVN1 UBXN4 VCP
Synapse:
DLG4 GABRD GRIN2A GRIN2B HOMER1 ITPR1 RPH3A SNAP25 SYN1
Outer Membrane Translocation:
TOMM20 TOMM22 TOMM34 TOMM40 TOMM40L TOMM70A
Regulation of Synaptic Transmission:
APOE BDNF CALB1 EGFR GNAQ GRIN2A GRIN2B HTT PPP3CA TAC1
Lipid Metabolism:
ABCA1 APOA1 APOE CLU HSD17B10 INS LPL LRP1 LRP8 SNCB
Synaptic Formation:
ACHE APBA1 APBB1 APBB2 APOE BDNF CHAT
Necrosis:
FAS GRB2 PARP1 PVR RIPK1 TNFRSF10A TNFRSF1A TXNL4B
Mitochondria:
CASP3 CASP7 CASP8 HSPA4 LRRK2 NEFL OPA1 PARK7 PINK1 PTEN SLC25A4 SNCA TH UCHL1 VAMP1 VDAC3 YWHAZ
Anti-Apoptosis:
APC BDNF CASP3 CASP9 NEFL NR4A2 OPA1 PPID PRDX2 PSEN2 PTEN SLC25A4 SNCA TCF7L2 UBB YWHAZ
Apoptotic Genes:
AIFM2 BAK1 BBC3 BCL2 BCL2L1 BID BNIP3 CDKN2A DNM1L MPV17 PMAIP1 SFN SH3GLB1 SOD2 TP53
Endocytosis:
APLP1 APP LRP1 LRP6 LRP8 C3 CLTC HIP1 PACSIN1
Other Peptidases:
IDE PLAT PLAU PLG
Mitochondrial Fission & Fusion:
COX10 COX18 FIS1 MFN1 MFN2 OPA1
Autophagy in Response to Other Intracellular Signals:
CTSD CTSS DRAM2 EIF4G1 ESR1 GAA HGS MAPK14 PIK3C3 PIK3R4 RPS6KB1 TMEM74 ULK2 UVRAG
Other Responses:
ATM ATR DDB2 GADD45A GADD45G RAD51 TP53 XPC
Notch:
APP PSEN2 SPEN
Small Molecule Transport:
SLC25A1 SLC25A10 SLC25A12 SLC25A13 SLC25A14 SLC25A15 SLC25A16 SLC25A17 SLC25A19 SLC25A2 SLC25A20 SLC25A21 SLC25A22 SLC25A23 SLC25A24 SLC25A25 SLC25A27 SLC25A3 SLC25A30 SLC25A31 SLC25A37 SLC25A4 SLC25A5
Cytoskeleton Reorganization:
APOE MAP2 MAPT PKP4 PRKCI
Genes Linking Autophagosome to Lysosome:
DRAM1 GABARAP LAMP1 NPC1
Parkin Complex:
HSPA4 PARK7 STUB1
Genes Responsible for Protein Targeting to Membrane / Vacuole:
ATG4A ATG4B ATG4C ATG4D GABARAP
MAP Kinase:
APC FGF13 MAPK9 PRDX2 RGS4
WNT Signaling:
GSK3A GSK3B LRP6
Proteases & Inhibitors:
ADAM10 APLP2 APP CAPN1 CTSC CTSD CTSG SERPINA3 UQCRC2
Mitochondrion Protein Import:
AIP COX10 COX18 GRPEL1 HSPD1 MIPEP SH3GLB1
Protein Disulfide Isomerization:
DDIT3 DNAJC10 ERO1L ERO1LB ERP44 PDIA3 VIMP SREBF1
Protein Folding:
CALR CANX CCT4 DNAJB9 DNAJC10 ERO1L ERP44 HSPA4L PFDN5 PPIA SEC63 SIL1 TCP1 TOR1A UGGT1
Mitochondrial Localization:
DNM1L LRPPRC MFN2 MSTO1 NEFL OPA1 RHOT1 RHOT2 UXT
Autophagy:
ATG12 ATG5 ATG7 BECN1 FAS ULK1
Parkin Substrate:
ATXN2 ATXN3 GPR37 SYT11
Postsynaptic Density (PSD):
DLG4 GRIN2A HOMER1 ITPR1
Autophagy Induction by Intracellular Pathogens:
EIF2AK3 IFNG LAMP1
Genes Responsible for Protein Transport:
ATG10 ATG16L1 ATG16L2 ATG3 ATG4A ATG4B ATG4C ATG4D ATG7 ATG9A GABARAP GABARAPL2 RAB24
Calcium Signaling/Homeostasis:
APOE ATP2B2 GNAQ GRIN2A GRIN2B HOMER1 ITPR1 PLCB1 PPP3CA TAC1 TGM2
Transporters:
ATP2B2 GRIA3 SLC18A2 SLC25A4 SLC6A3 SV2B SYT1 SYT11 VDAC3
Cell Adhesion:
APC APP CDH8 FN1 NFASC NRXN3 PTEN TPBG
Transcription Factor Targets SP1:
AKT1 APOE AQP1 ARFIP2 BDNF C3 CASP8 CD44 CLTC CREBBP DLG4 FGF12 GJA1 GJB6 GPX1 GRB2 GRIN2A HAP1 HDAC1 HOMER1 HPCA HTT KCNC3 LPL MAP3K10 PACSIN1 PRKCB RAB6A REST RILP RXRB SGK1 SIN3A SOD1 SOX2 SP1 SYMPK SYN1 TGM2 TOLLIP TP53 TUBB
Cytoskeleton:
AKT1 CASP8 DCTN1 DLG4 ELMO1 GRIN2A HAP1 HIP1 HOMER1 IFT57 ITPR1 NCOR1 NEFL SYMPK TUBB
ER Protein Folding Quality Control:
EDEM1 ERP44 GANAB GANC PRKCSH RPN1 SERP1 UGGT1
Cell Cycle Checkpoint/Arrest:
CDKN1A CHEK1 CHEK2 DDIT3 HUS1 MRE11A NBN RAD17 RAD9A
Neurotransmitter Receptors:
CNR1 GABRD GRIN2A GRIN2B GRM5 NTRK2

LncRNA List

The mouse neurodegenerative disease focused LncRNAs are listed in Table 1. Click the LncRNA accession numbers to see the detailed information about the LncRNAs and their potential coding gene targets in neurodegenerative diseases.

Table 1. Mouse Neurodegenerative disease focused LncRNAs

ENSMUST00000044964, ENSMUST00000054781, ENSMUST00000092369, ENSMUST00000099446, ENSMUST00000099710, ENSMUST00000105060, ENSMUST00000117520, ENSMUST00000117905, ENSMUST00000118705, ENSMUST00000118796, ENSMUST00000119460, ENSMUST00000121061, ENSMUST00000122882, ENSMUST00000124336, ENSMUST00000124577, ENSMUST00000124663, ENSMUST00000125440, ENSMUST00000125464, ENSMUST00000126212, ENSMUST00000127079, ENSMUST00000127174, ENSMUST00000128182, ENSMUST00000128654, ENSMUST00000129200, ENSMUST00000129526, ENSMUST00000129527, ENSMUST00000131387, ENSMUST00000131456, ENSMUST00000132117, ENSMUST00000133909, ENSMUST00000135110, ENSMUST00000135913, ENSMUST00000136359, ENSMUST00000136437, ENSMUST00000140071, ENSMUST00000140238, ENSMUST00000140955, ENSMUST00000141229, ENSMUST00000141347, ENSMUST00000141645, 

Full List of Mouse Neurodegenerative Disease Related LncRNAs.pdf

Gene List

The potential gene targets of mouse neurodegenerative disease focused LncRNAs are listed in Table 2. Click the protein gene names to see the detailed information about the genes and their corresponding regulatory LncRNAs in the neurodegenerative diseases.

Table 2. Functional gene grouping

GABAergic:
Drd2 Gabbr2
Genes Involved in Autophagic Vacuole Formation:
Ambra1 Atg12 Atg16l1 Atg4a Atg4b Atg4c Atg4d Atg5 Atg9a Atg9b Becn1 Gabarap Gabarapl1 Gabarapl2 Irgm1 Map1lc3a Map1lc3b Rgs19 Ulk1 Wipi1
Chaperone-Mediated Autophagy:
Hsp90aa1 Hspa8
Membrane Polarization & Potential:
Bak1 Bcl2 Bcl2l1 Bnip3 Sod1 Trp53 Ucp1 Ucp2 Ucp3
Transcription:
Apbb1 Apbb2 Ep300 Ern1
Dopaminergic:
Nsg1 Ddc Drd2 Htr2a Nr4a2 Park2 Park7 Pink1 Slc6a3 Snca Th
Other Genes:
A2m Ache Apbb1 Apbb2 Apoe Bche Ubqln1 Gap43 Gnb2 Ide Il1a Insr Nae1 Plau
Mitochondrial Transport:
Aip Bak1 Bcl2 Bcl2l1 Bnip3 Cpt1b Cpt2 Grpel1 Hsp90aa1 Hspd1 Immp2l Mfn2 Mipep Mtx2 Stard3 Trp53 Tspo Ucp1 Ucp2 Ucp3
Pro-Apoptosis:
Apc App Casp1 Casp3 Casp8 Casp9 Cul2 Mapk9 Psen2 Pten
Huntingtin Cofactors:
Cltc Crebbp Dctn1 Dlg4 Egfr Grb2 Hap1 Hdac2 Hip1 Map3k10 Ncor1 Pacsin1 Prpf40a Ptpn11 Rcor1 Rest Sin3a Sp1 Sympk Tbp Trp53
Heat Shock Proteins/Unfolded Protein Response:
Atf4 Atf6 Atf6b Bid Calr Ddit3 Dnajc3 Hsp90aa1 Hsp90b1 Hspa4 Hspa5
Genes with Protease Activity:
Atg4a Atg4b Atg4c Atg4d
Regulation of Cholesterol Metabolism:
Insig2 Mbtps1 Mbtps2 Scap Srebf1
Cell Cycle:
Apbb1 Apbb2 Cdk1 Cdk5 Cdkl1 Ep300 Ern1 Il1a Nae1 Prkca
Inflammation:
Fn1 Prdx2 Ywhaz
Regulation of Translation:
Eif2a Eif2ak3 Ppp1r15a Serp1
Pathway Activity Signature Genes:
Adm2 Asns Bex2 Ddit3 Dnajb9 Gins2 Herpud1 Inhbe Kcnmb3 Mcm4 Pcna Rrm2 Slc17a2 Trib3 Tyms Uhrf1
Transcription Factors:
Atf4 Atf6 Atf6b Atxn3 Calr Cebpb Creb3 Creb3l3 Ddit3 Ern1 Ern2 Mbtps1 Pfdn5 Scap Srebf1 Xbp1
Inflammatory Response:
Ccl12 Cd40lg Crp Ifng Il1a Il1b Il6 Tlr4 Tnf
Unfolded Protein Binding:
Calr Canx Cct4 Dnajb9 Dnajc10 Ero1lb Hspa1a Hspa1b Hspa2 Htra2 Pfdn5 Ppia Scap Sec63 Sil1 Tcp1 Tor1a Uggt1
Heat Shock Proteins:
Dnajb9 Dnajc10 Dnajc3 Hspa4 Hspa5 Hsph1 Sec63
Intracellular Signaling:
Apba3 Apbb2 Prkca Prkcb Prkcd Prkce Prkcg Prkci Prkcq Prkcz Psen1 Psen2
Secretases:
Adam9 Aph1a Bace1 Bace2 Ctsb Ncstn Psen1 Psen2
Targeting Proteins to Mitochondria:
Aip Grpel1 Hspd1 Immp2l Mfn2 Mipep Tspo
Hypoxia:
Adm Arnt Bnip3l Car9 Epo Hmox1 Ldha Mmp9 Serpine1 Slc2a1 Vegfa
Co-Regulators of Autophagy and the Cell Cycle:
Bax Cdkn1b Cdkn2a Ifng Pten Rb1 Tgfb1 Trp53
Synaptic Vesicles:
Lrrk2 Sv2b Syngr3 Syt1 Syt11 Th
Apoptosis:
Aplp1 App Casp3 Casp4 Ep300 Ern1 Il1a Mapt Mpo Nae1 Prkca Prkce Prkcz Psen1 Psen2 Snca Akt1 Apoe Bax Bdnf Casp3 Casp8 Cd44 Creb1 Eef1a2 Egfr Elmo1 Gjb6 Grin2a Hip1 Htt Ift57 Igf1 Map3k10 Nefl Ngef Sgk1 Slc25a4 Sox2 Tbp Trp53 Tubb5 Zbtb16 Casp1 Fas Mcl1 Tnfrsf10b Tnfrsf1a Atxn3 Bax Calr Cebpb Ddit3 Eif2ak3 Ern1 Ern2 Hspa1a Hspa1b Htra2 Manf Mapk8 Mapk9 Pdia3 Ppp1r15a Vimp Vcp
G-protein Coupled Receptor Signaling:
Aplp2 Gnao1 Gnaz Gnb1 Gnb4 Gnb5 Gng11 Gng3 Gng4 Gngt1 Gngt2 Ntrk1 Ntrk2
Oxidation/Reduction:
Apoe Bbox1 Egfr Gpx1 Kcnab1 Kcnab2 Plod2 Ppargc1a Sod1
Ion Transport:
Atp2b2 Cadps Cxxc1 Drd2 Egln1 Gbe1 Gria3 Htr2a Kcnj6 Nsf Psen2 S100b Slit1 Snca Srsf7 Vdac3 Akt1 Aqp1 Atp2b2 Gabrd Grin2a Homer1 Htt Itpr1 Kcnab1 Kcnab2 Kcnc3 Ppp3ca Sgk1
Notch Signaling:
Adam10 Aph1a Ncstn Psen1 Psen2
Cytoskeletal Organization:
Apc Cdc42 Mapt Nefl Park2
Oxidative Stress:
Hsd17b10 Mpo Uqcrc1 Uqcrc2 Fth1 Gclc Gclm Gsr Gstp1 Gstp2 Hmox1 Nqo1 Prdx1 Sqstm1 Txn1 Txnrd1
Genes Involved in Protein Ubiquitination:
Atg3 Atg7 Hdac6
Others:
Aldh1a1 Basp1 Chgb Dlk1 Ncoa1 Ntrk2 Rtn1 Pgk1 Rgs4 Slc14a1
Osmotic Stress:
Akr1b3 Aqp1 Aqp2 Aqp4 Cftr Edn1 Hspa4l Nfat5 Slc5a3
Cytoskeleton Organization:
Apoe Arfip2 Elmo1 Ncor1 Nefl Pacsin1 Tac1 Tubb5
Co-Regulators of Autophagy and Apoptosis:
Akt1 App Atg12 Atg5 Bad Bak1 Bax Bcl2 Bcl2l1 Becn1 Bid Bnip3 Casp3 Casp8 Cdkn1b Cdkn2a Cln3 Ctsb Cxcr4 Dapk1 Dram1 Eif2ak3 Fadd Fas Hdac1 Htt Ifng Igf1 Ins2 Mapk8 Mtor Nfkb1 Pik3cg Prkaa1 Pten Snca Sqstm1 Tgfb1 Tgm2 Tnf Tnfsf10 Trp53
Inner Membrane Translocation:
Immp1l Immp2l Opa1 Taz Timm10 Timm17a Timm17b Timm22 Timm23 Timm44 Timm50 Timm8a1 Timm8b Timm9
Transcription Factor Targets REST:
Bdnf Calb1 Dlg4 Eef1a2 Elmo1 Fgf12 Gabrd Grin2a Kcnab2 Kcnc3 Nefl Rph3a Rxrb Snap25 Syn1 Tollip Tubb5
Ubiquitination:
Cdc27 Cul2 Fbxo9 Lrrk2 Pan2 Park2 Pink1 Skp1a Stub1 Uba1 Ube2i Ube2k Ube2l3 Uchl1 Usp34 Amfr Herpud1 Rnf5 Sec62 Sel1l Ube2g2 Ubxn4 Ufd1l Usp14 Vcp
ER Associated Degradation (ERAD):
Amfr Derl1 Edem1 Fbxo6 Herpud1 Htra2 Htra4 Mbtps1 Mbtps2 Nploc4 Nucb1 Os9 Sec62 Sel1l Vimp Syvn1 Ubxn4 Vcp
Synapse:
Dlg4 Gabrd Grin2a Grin2b Homer1 Itpr1 Rph3a Snap25 Syn1
Outer Membrane Translocation:
Tomm20 Tomm22 Tomm34 Tomm40 Tomm40l Tomm70a
Regulation of Synaptic Transmission:
Apoe Bdnf Calb1 Egfr Gnaq Grin2a Grin2b Htt Ppp3ca Tac1
Lipid Metabolism:
Abca1 Apoa1 Apoe Hsd17b10 Ins2 Lpl Lrp1 Lrp8 Sncb
Synaptic Formation:
Ache Apba1 Apbb1 Apbb2 Apoe Bdnf Chat
Necrosis:
Fas Grb2 Parp1 Ripk1 Tnfrsf10b Tnfrsf1a Txnl4b
Mitochondria:
Casp3 Casp7 Casp8 Hspa4 Lrrk2 Nefl Opa1 Park7 Pink1 Pten Slc25a4 Snca Th Uchl1 Vamp1 Vdac3 Ywhaz
Anti-Apoptosis:
Apc Bdnf Casp3 Casp9 Nefl Nr4a2 Opa1 Ppid Prdx2 Psen2 Pten Slc25a4 Snca Tcf7l2 Ywhaz
Apoptotic Genes:
Aifm2 Bak1 Bcl2 Bcl2l1 Bid Bnip3 Cdkn2a Dnm1l Mpv17 Sfn Sh3glb1 Sod2 Trp53
Endocytosis:
Aplp1 App Lrp1 Lrp6 Lrp8 C3 Cltc Hip1 Pacsin1
Other Peptidases:
Ide Plat Plau Plg
Mitochondrial Fission & Fusion:
Cox10 Cox18 Fis1 Mfn1 Mfn2 Opa1
Autophagy in Response to Other Intracellular Signals:
Ctsd Ctss Dram2 Eif4g1 Esr1 Gaa Hgs Mapk14 Pik3c3 Pik3r4 Rps6kb1 Tmem74 Ulk2 Uvrag
Other Responses:
Atm Atr Ddb2 Gadd45a Gadd45g Rad51 Trp53 Xpc
Notch:
App Psen2 Spen
Small Molecule Transport:
Slc25a1 Slc25a10 Slc25a12 Slc25a13 Slc25a14 Slc25a15 Slc25a16 Slc25a17 Slc25a19 Slc25a20 Slc25a21 Slc25a22 Slc25a23 Slc25a24 Slc25a25 Slc25a27 Slc25a3 Slc25a30 Slc25a31 Slc25a37 Slc25a4 Slc25a5
Cytoskeleton Reorganization:
Apoe Mapt Pkp4 Prkci
Genes Linking Autophagosome to Lysosome:
Dram1 Gabarap Lamp1 Npc1
Parkin Complex:
Hspa4 Park7 Stub1
Genes Responsible for Protein Targeting to Membrane / Vacuole:
Atg4a Atg4b Atg4c Atg4d Gabarap
MAP Kinase:
Apc Fgf13 Mapk9 Prdx2 Rgs4
WNT Signaling:
Gsk3a Gsk3b Lrp6
Proteases & Inhibitors:
Adam10 Aplp2 App Capn1 Ctsc Ctsd Ctsg Serpina3n Uqcrc2
Mitochondrion Protein Import:
Aip Cox10 Cox18 Grpel1 Hspd1 Mipep Sh3glb1
Protein Disulfide Isomerization:
Ddit3 Dnajc10 Ero1l Ero1lb Erp44 Pdia3 Vimp Srebf1
Protein Folding:
Calr Canx Cct4 Dnajb9 Dnajc10 Ero1l Erp44 Hspa4l Pfdn5 Ppia Sec63 Sil1 Tcp1 Tor1a Uggt1
Mitochondrial Localization:
Dnm1l Lrpprc Mfn2 Msto1 Nefl Opa1 Rhot1 Rhot2 Uxt
Autophagy:
Atg12 Atg5 Atg7 Becn1 Fas Ulk1
Parkin Substrate:
Atxn2 Atxn3 Gpr37 Syt11
Postsynaptic Density (PSD):
Dlg4 Grin2a Homer1 Itpr1
Autophagy Induction by Intracellular Pathogens:
Eif2ak3 Ifng Lamp1
Genes Responsible for Protein Transport:
Atg10 Atg16l1 Atg16l2 Atg3 Atg4a Atg4b Atg4c Atg4d Atg7 Atg9a Gabarap Gabarapl2 Rab24
Calcium Signaling/Homeostasis:
Apoe Atp2b2 Gnaq Grin2a Grin2b Homer1 Itpr1 Plcb1 Ppp3ca Tac1 Tgm2
Transporters:
Atp2b2 Gria3 Slc18a2 Slc25a4 Slc6a3 Sv2b Syt1 Syt11 Vdac3
Cell Adhesion:
Apc App Cdh8 Fn1 Nfasc Pten Tpbg
Transcription Factor Targets SP1:
Akt1 Apoe Aqp1 Arfip2 Bdnf C3 Casp8 Cd44 Cltc Crebbp Dlg4 Fgf12 Gja1 Gjb6 Gpx1 Grb2 Grin2a Hap1 Hdac1 Homer1 Hpca Htt Kcnc3 Lpl Map3k10 Pacsin1 Prkcb Rab6a Rest Rilp Rxrb Sgk1 Sin3a Sod1 Sox2 Sp1 Sympk Syn1 Tgm2 Tollip Trp53 Tubb5
Cytoskeleton:
Akt1 Casp8 Dctn1 Dlg4 Elmo1 Grin2a Hap1 Hip1 Homer1 Ift57 Itpr1 Ncor1 Nefl Sympk Tubb5
ER Protein Folding Quality Control:
Edem1 Erp44 Ganab Ganc Prkcsh Rpn1 Serp1 Uggt1
Cell Cycle Checkpoint/Arrest:
Cdkn1a Chek1 Chek2 Ddit3 Hus1 Mre11a Nbn Rad17 Rad9
Neurotransmitter Receptors:
Cnr1 Gabrd Grin2a Grin2b Grm5 Ntrk2