• Description
  • Highlights
  • Human Database
  • Mouse Database
Product NameCatalog NoDescriptionFormatPrice
LncPath™ Human Necroptosis Pathway Microarray AS-LP-011H 428 LncRNAs and 106 their potential coding targets 8*15K
LncPath™ Mouse Necroptosis Pathway Microarray AS-LP-011M 122 LncRNAs and 180 their potential coding targets 8*15K

Necrosis, like apoptosis, can occur in a regulated manner known as "necroptosis" [2]. Necroptosis participates in the pathogenesis of diseases during ischemic injury, neurodegeneration and viral infection, thereby representing an attractive target to avoid unwarranted cell death [1]. Understanding the molecular mechanisms and the pathophysiology of the necroptosis pathway is an important goal of biological research.

The LncPath™ Human Necroptosis Pathway LncRNA Microarray simultaneously profiles the expression of 428 LncRNAs and 106 their protein-coding gene targets related to the necroptosis signaling pathway. The LncPath™ Mouse Necroptosis Pathway LncRNA Microarray simultaneously profiles the expression of 122 LncRNAs and 180 their protein-coding gene targets related to the necroptosis signaling pathway. The LncRNAs whose genes are located at or near the protein-coding genes critical in the necroptosis pathway, and the LncRNAs that have high possibilities of being competing endogenous RNAs (ceRNAs) of the key necroptosis pathway genes, are carefully collected from authoritative databases using rigorous selection processes. By focusing on the LncRNAs most relevant to the necroptosis pathway, the array can achieve much faster and more precise analysis, due to the highly specific yet smaller amount of data to analyze. More importantly, it can establish the expressional relationships between the LncRNAs and their protein-coding gene targets involved in the necroptosis pathway, thereby providing comprehensive insights into the underlying regulatory mechanisms of LncRNAs in the necroptosis pathway.

Comprehensive and reliable collection of necroptosis pathway focused LncRNAs.

Simultaneous analysis of LncRNAs and their protein-coding gene targets in the necroptosis pathway.

Explore and establish expressional relationships and regulatory mechanisms between the LncRNAs and the target pathway genes.

Faster and more precise pathway-focused analysis.

Efficient and robust labeling system.

Innovative probe design.

Guaranteed performance.

An example showing the detailed information about the LncRNAs and their potential coding gene target

Click the LncRNA accession number listed in databases, you will see the figures showing the detailed information about the LncRNAs and their potential target gene.

CYLD

Figure 1. The genomic map views of the LncRNA ENST00000563315 and its potential target gene CYLD. From the top to the bottom of the figure 1, the following items are displayed:

Genome view: A chromosome ideogram showing the map position of the LncRNA ENST00000563315 and its potential target gene CYLD(red bar).

Map view ruler: The map coordinates of the human genome assembly hg19 for the map views below.

LncRNA map view: The LncRNAs whose genes located at or near the CYLD gene are presented in the Noncoding panel (shaded green). The LncRNAs are indicated by the transcript IDs, the exons by solid blocks, the introns by thin lines, and the transcription directions by arrows. The exons of LncRNA ENST00000563315 are labeled in red, while the exons of the other LncRNAs are labeled in blue.

Coding gene map view: The coding gene CYLD is presented in the Coding panel (shaded blue). The coding gene is indicated by its canonical transcript ID, the exons by solid blocks, the introns by thin lines, and the transcription direction by arrows.

CYLD-1

Figure 2. The relationship between LncRNA ENST00000563315 and its protein coding gene target CYLD. The other neighboring LncRNAs which may regulate CYLD expression are also shown.

CYLD-2

Figure 3. The LncRNA uc003hkh.3 may function as a competing endogenous RNA (ceRNA) of the protein coding gene CYLD.

* MuTaMe Score, Mutually Targeted MRE Enrichment Score [3].

References
1.Vandenabeele, P., et al. (2010) Nat Rev Mol Cell Biol 11 (10): 700-14.
2.Galluzzi, L. and G. Kroemer (2008) Cell 135 (7): 1161-3.
3.Tay, Y., et al. (2011) Cell 147 (2): 344-57.

List of LncRNAs

The LncRNAs collected for the human necroptosis pathway are listed in Table 1. Click an LncRNA accession number to see its detailed information and its potential target gene(s) in the necroptosis pathway.

Table 1. Human Necroptosis Pathway focused LncRNAs

ENST00000279573, ENST00000292748, ENST00000335507, ENST00000381143, ENST00000400985, ENST00000413053, ENST00000414855, ENST00000420498, ENST00000424471, ENST00000424664, ENST00000424739, ENST00000424850, ENST00000425022, ENST00000428188, ENST00000430499, ENST00000433871, ENST00000436426, ENST00000436818, ENST00000438019, ENST00000440965, ENST00000445082, ENST00000445196, ENST00000445404, ENST00000446874, ENST00000446992, ENST00000447723, ENST00000448942, ENST00000449307, ENST00000450638, ENST00000453979, ENST00000458331, ENST00000459877, ENST00000460407, ENST00000460823, ENST00000464624, ENST00000466750, ENST00000468221, ENST00000469356, ENST00000473478, ENST00000474886, ENST00000476719, ENST00000476992, ENST00000489980, ENST00000492278, ENST00000493035, ENST00000497955, ENST00000499554, ENST00000505114, ENST00000506485, ENST00000508517, 

Full List of Human Necroptosis Pathway Focused LncRNAs.pdf

Gene List

The potential gene targets of human necroptosis pathway focus LncRNAs are listed in Table 2. Click the protein gene names to see the detailed information about the genes and their corresponding regulatory LncRNAs in the necroptosis pathway.

Table 2. Functional gene grouping

Execution of necroptosis:
AIFM1 CAPN1 CAPN2 PPID PARP1 PPIF GLUD1 GLUL MAPK8 NOX1 PYGL RIPK3 CAPN1 CAPN2 KAT5 HSPA1A HSPA1B HSPA4 LOX SMPD2
TNFR1 elicited signalling pathways:
TNFAIP3 CASP8 BIRC2 BIRC3 BIRC5 BIRC7 XIAP CYLD BRCA2 FANCD2 PSEN1 FADD FMN1 CYBA RFK RIPK1 RIPK3 TNF TNFRSF1A TRADD TRAF2 TRAF5 USP21
Necroptosis Initiation:
FASLG HSP90B1 HMGB1 HMGN1 HSP90AA1 IL1A IL33 S100B TNF CD14 CD24 CD28 CD40 LRP1 CLEC9A IL1R1 IL1RAP P2RX1 P2RX2 P2RX3 P2RX4 P2RX5 P2RX6 P2RX7 LPAR4 LPAR6 P2RY1 P2RY10 P2RY11 P2RY12 P2RY13 P2RY14 P2RY2 P2RY4 P2RY6 P2RY8 MOK DDX58 IL1RL1 TLR2 TLR3 TLR4 TLR6 TLR7 TLR9 ZBP1 MAVS LY96 MYD88 CD22 SIGLEC10 SIGLEC8 TBK1 TRAF2 TRAF5 TRAF6 TICAM2 TRIM69 BIRC2 BIRC3 BIRC5 BIRC7 XIAP FAF1 FYN LCK RIPK1 ZAP70
The functional interactome of TNFR1 in necroptosis:
CASP8 ASAH1 BIRC2 BIRC3 BIRC5 BIRC7 XIAP KAT5 CYLD FADD MAPK8 LOX NOX1 OTUD7B RFK RIPK1 RIPK3 SMPD1 SMPD2 TNF TNFAIP3 TNFRSF1B TRADD TRAF2 TRAF5 USP21
Necrotic complexes:
CASP8 FADD RIPK1 RIPK3 TRADD CASP10 CASP8 CFLAR FADD RIPK1 RIPK3 RIPK1 RIPK3 TRIM69

 

List of LncRNAs

The LncRNAs collected for the mouse necroptosis pathway are listed in Table 1. Click an LncRNA accession number to see its detailed information and its potential target gene(s) in the necroptosis pathway.

Table 1. Mouse Necroptosis Pathway focused LncRNAs

2_00014852, Hipk2, ENSMUST00000119987, ENSMUST00000125440, Ucp2, ENSMUST00000127079, ENSMUST00000127908, ENSMUST00000128182, ENSMUST00000131456, ENSMUST00000135110, Zfp385b, Foxp1, ENSMUST00000146690, ENSMUST00000148268, ENSMUST00000155324, ENSMUST00000156243, ENSMUST00000157052, ENSMUST00000159203, ENSMUST00000159507, Atrip, Adrbk1, ENSMUST00000164558, ENSMUST00000170214, ENSMUST00000170766, ENSMUST00000171467, ENSMUST00000173358, Il1rap, ENSMUST00000174777, ENSMUST00000180695, ENSMUST00000180988, ENSMUST00000181752, ENSMUST00000182811, NR_015572, NR_027380, NR_040256, NR_040601, NR_045831, NR_073191, TCONS_00002339, TCONS_00004072, TCONS_00006744, TCONS_00006745, TCONS_00007997, TCONS_00012231, TCONS_00017605, TCONS_00017645, TCONS_00022576, TCONS_00025057, TCONS_00027338, TCONS_00029303, uc007fko.1, uc007gqf.1, uc007gqh.1, 

Full List of Mouse Necroptosis Pathway Focused LncRNAs.pdf

Gene List 

The potential gene targets of mouse necroptosis pathway focus LncRNAs are listed in Table 2. Click the protein gene names to see the detailed information about the genes and their corresponding regulatory LncRNAs in the necroptosis pathway.

Table 2. Functional gene grouping

Execution of necroptosis:
Aifm1 Capn1 Capn2 Ppid Parp1 Ppif Glud1 Glul Mapk8 Nox1 Pygl Ripk3 Capn1 Capn2 Kat5 Hspa1a Hspa1b Hspa1a Hspa1b Hspa4 Lox Smpd2
TNFR1 elicited signalling pathways:
Tnfaip3 Casp8 Birc2 Birc3 Birc5 Birc7 Xiap Cyld Brca2 Fancd2 Psen1 Fadd Cyba Rfk Ripk1 Ripk3 Tnf Tnfrsf1a Tradd Traf2 Traf5 Usp21
Necroptosis Initiation:
Fasl Hsp90b1 Hmgb1 Hsp90aa1 Il1a Il33 S100b Tnf Cd14 Cd28 Cd40 Lrp1 Clec9a Il1r1 Il1rap P2rx1 P2rx2 P2rx3 P2rx4 P2rx5 P2rx6 P2rx7 Lpar4 Lpar6 P2ry1 P2ry10 P2ry12 P2ry13 P2ry14 P2ry2 P2ry4 P2ry6 Stk30 Ddx58 Il1rl1 Tlr2 Tlr3 Tlr4 Tlr6 Tlr7 Tlr9 Zbp1 Mavs Ly96 Myd88 Cd22 Siglecg Siglece Tbk1 Traf2 Traf5 Traf6 Ticam2 Trim69 Birc2 Birc3 Birc5 Birc7 Xiap Faf1 Fyn Lck Ripk1 Zap70
The functional interactome of TNFR1 in necroptosis:
Casp8 Asah1 Birc2 Birc3 Birc5 Birc7 Xiap Kat5 Cyld Fadd Mapk8 Lox Nox1 Otud7b Rfk Ripk1 Ripk3 Smpd1 Smpd2 Tnf Tnfaip3 Tnfrsf1b Tradd Traf2 Traf5 Usp21
Necrotic complexes:
Casp8 Fadd Ripk1 Ripk3 Tradd Casp8 Cflar Fadd Ripk1 Ripk3 Ripk1 Ripk3 Trim69