• Description
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  • Human Database
  • Mouse Database
Product NameCatalog NoDescriptionFormatPrice
LncPath™ Human Hippo Pathway Microarray AS-LP-009H 662 LncRNAs and 157 their potential coding targets 8*15K
LncPath™ Mouse Hippo Pathway Microarray AS-LP-009M 379 LncRNAs and 267 their potential coding targets 8*15K

The Hippo pathway is an evolutionarily conserved pathway that regulates cell proliferation, apoptosis, stem cell self-renewal, and tissue regeneration. Dysregulation of the Hippo pathway contributes to a broad range of human carcinomas, including lung, colorectal, ovarian, breast and liver cancer [1]. Understanding of the Hippo pathway regulation may shed new insights to novel strategies for cancer treatment.

The LncPath™ Human Hippo Pathway LncRNA Microarray simultaneously profiles the expression of 662 LncRNAs and 157 their potential coding targets related to the Hippo signaling pathway. The LncPath™ Mouse Hippo Pathway LncRNA Microarray simultaneously profiles the expression of 379 LncRNAs and 267 their potential coding targets related to the Hippo signaling pathway. The LncRNAs whose genes are located at or near the protein-coding genes critical in the Hippo pathway, and the LncRNAs that have high possibilities of being competing endogenous RNAs (ceRNAs) of the key Hippo pathway genes, are carefully collected from authoritative databases using rigorous selection processes. By focusing on the LncRNAs most relevant to the Hippo pathway, the array can achieve much faster and more precise analysis, due to the highly specific yet smaller amount of data to analyze. More importantly, it can establish the expressional relationships between the LncRNAs and their protein-coding gene targets involved in the Hippo signaling pathway, thereby providing comprehensive insights into the underlying regulatory mechanisms of LncRNAs in the Hippo pathway.

Comprehensive and reliable collection of Hippo pathway focused LncRNAs.

Simultaneous analysis of LncRNAs and their protein-coding gene targets in the Hippo pathway.

Explore and establish expressional relationships and regulatory mechanisms between the LncRNAs and the target pathway genes.

Faster and more precise pathway-focused analysis.

Efficient and robust labeling system.

Innovative probe design.

Guaranteed performance.

An example showing the detailed information about the LncRNAs and their potential coding gene target

Click the LncRNA accession number listed in databases, you will see the figures showing the detailed information about the LncRNAs and their potential target gene.

ATCG1

Figure 1. The genomic map views of the LncRNA ENST00000430912 and its potential target gene ACTG1. From the top to the bottom of the figure 1, the following items are displayed:

Genome view: A chromosome ideogram showing the map position of the LncRNA ENST00000430912 and its potential target gene ACTG1 (red bar).

Map view ruler: The map coordinates of the human genome assembly hg19 for the map views below.

LncRNA map view: The LncRNAs whose genes located at or near the ACTG1 gene are presented in the Noncoding panel (shaded green). The LncRNAs are indicated by the transcript IDs, the exons by solid blocks, the introns by thin lines, and the transcription directions by arrows. The exons of LncRNA ENST00000430912 are labeled in red, while the exons of the other LncRNAs are labeled in blue.

Coding gene map view: The coding gene ACTG1 is presented in the Coding panel (shaded blue). The coding gene is indicated by its canonical transcript ID, the exons by solid blocks, the introns by thin lines, and the transcription direction by arrows.

ATCG1-2

Figure 2. The relationship between LncRNA ENST00000430912 and its protein coding gene target ACTG1. The other neighboring LncRNAs which may regulate ACTG1 expression are also shown.

ATCG1-3

Figure 3. The LncRNA TCONS_00006371 may function as a competing endogenous RNA (ceRNA) of the protein coding gene ACTG1.

* MuTaMe Score, Mutually Targeted MRE Enrichment Score.

References
1.Harvey, K. F., et al. (2013) Nat Rev Cancer 13 (4): 246-57.
2.Tay, Y., et al. (2011) Cell 147 (2): 344-57.

List of LncRNAs

The LncRNAs collected for the human Hippo pathway are listed in Table 1. Click an LncRNA accession number to see its detailed information and its potential target gene(s) in the Hippo pathway.

Table 1. Human Hippo pathway focuse LncRNAs

ENST00000279573, ENST00000333854, ENST00000339626, ENST00000358708, ENST00000366105, ENST00000391360, ENST00000398690, ENST00000412173, ENST00000412239, ENST00000413053, ENST00000414314, ENST00000414529, ENST00000416342, ENST00000416554, ENST00000417082, ENST00000417589, ENST00000419351, ENST00000419973, ENST00000421764, ENST00000422040, ENST00000422250, ENST00000422510, ENST00000425245, ENST00000426302, ENST00000427601, ENST00000427644, ENST00000428391, ENST00000429132, ENST00000429512, ENST00000429630, ENST00000429798, ENST00000430912, ENST00000432706, ENST00000433396, ENST00000433876, ENST00000433945, ENST00000434672, ENST00000434996, ENST00000435057, ENST00000435287, ENST00000436286, ENST00000436416, ENST00000436882, ENST00000437203, ENST00000437207, ENST00000437213, ENST00000437586, ENST00000437797, ENST00000438379, ENST00000439433, 

Full List of Human Hippo Pathway Focused LncRNAs.pdf

Gene List

The potential gene targets of human Hippo pathway focus LncRNAs are listed in Table 2. Click the protein gene names to see the detailed information about the genes and their corresponding regulatory LncRNAs in the Hippo pathway.

Table 2. Functional gene grouping

Hippo Core Kinase Complex:
LATS2 MOB1B MOB1A MST1 STK4 SAV1 STK3 STK4 TAZ WWTR1 YAP1
Downstream Mediators:
HIPK2 MAPK10 meis1 PRKCI PRKCZ SMAD1 TEAD1 TEAD2 TEAD3 TEAD4 TP63 TSHZ1 TSHZ2 TSHZ3 WNT1
Contact Inhibition:
NF2 TAZ YAP1
Target Genes:
CASP3 CCNE1 CCNE2 MYC PPP2CB PPP2R1A PPP2R2D PTPN14 RERE
Upstream Regulators:
ACTG1 AMOT AMOTL1 AMOTL2 CASP3 CRB1 CRB2 CRB3 CSNK1D CSNK1E DCHS1 DCHS2 DIAPH2 DLG1 DVL2 FAT1 FAT2 FAT3 FAT4 FJX1 AJUBA LIMD1 LIX1L LLGL1 LLGL2 LPP NF2 RASSF4 SCRIB WTIP WWC1 ZDHHC18
Cell Polarity:
CRB1 CRB2 CRB3 DCHS1 DCHS2 FAT1 FAT2 FAT3 FAT4 GPC5 HMCN1 LATS1 LATS2 MPDZ MPP5 MST1 STK4 NPHP4 PARD3 PARD6G POTEE POTEI SCRIB STK3 STK4 TAOK1 TAOK2 TAOK3 TJP1 TJP2
Target genes:
AREG BIRC5 CTGF AJUBA GNA12 GNA13 GNAI1 GNAI2 GNAI3 GNAQ HIPK2 ANKHD1 ANKHD1 PPP2R4 RHO TAZ TEAD1 TEAD2 TEAD3 TEAD4 WBP2 YY1AP1 YWHAQ AMOT CSNK1A1 CRB3 CDH1 WWC1 LATS1 LATS2 STK4 STK3 NF2 SGMS1 MPP5 INADL PTPN14 RASSF1 RASSF2 RASSF3 RASSF4 RASSF5 SAV1 SCRIB TAOK1 FRMD6 BTRC
Key Components of Hippo Signaling Pathway:
CD44 CRB1 CRB2 CRB3 DCHS1 DCHS2 CDH1 FAT4 LATS1 LATS2 MOB1A MOB1B MST1 STK4 STK3 SAV1 TAZ YY1AP1 CSNK1D CSNK1E FJX1 LIX1 LIX1L ZDHHC14 ZDHHC18 ZDHHC9 ZYX AJUBA AMOT PRKCI PRKCZ DLG1 WWC1 LLGL1 LLGL2 LIMD1 NF2 MPP5 PARD3 PARD6A PTPN14 SCRIB FRMD6 WTIP TJP1 TJP2 CTNNA1 CTNNB1 YWHAQ PPP1R13B ITCH PPP2R4 RASSF1 RASSF2 RASSF3 RASSF4 RASSF5 RASSF6 TAOK1 TAOK2 TAOK3 BTRC TP63 meis1 MEIS2 MEIS3 TP73 PAX3 PPARG pKnox1 PKNOX2 RUNX2 TBX5 TEAD1 TEAD2 TEAD3 TEAD4 TSHZ1 TSHZ2 TSHZ3 NKX2-1 WBP2 AFP AREG BIRC2 BIRC5 CCND1 CDX2 CTGF CCNE1 CYR61 DIAPH1 E2F1 FGF1 FGF2 GLI2 ITGB2 TP53AIP1 BBC3 SMAD7 LATS2 MOB1B MOB1A MST1 STK4 SAV1 STK3 STK4 TAZ WWTR1 YAP1 RASSF5 RAF1 TERF2IP HRAS KRAS NRAS RASSF1 RASSF2 RASSF3 RASSF4 RASSF5 RASSF6 AMOT AURKA WWC1 STK3 MOB1A MST1 STK4 YWHAQ AMOT AMOTL1 AMOTL2 CSNK1D CSNK1E LATS1 LATS2 KITLG TJP2 CTNNA1 BTRC FOXO1 FOXO3 LATS1 LATS2 MOB1A NDRG1 STK38L SAV1 TAZ YY1AP1 TP73 PAX3 PPARG RUNX2 SMAD2 SMAD3 SMAD4 TBX5 TEAD1 TEAD2 TEAD3 TEAD4 NKX2-1
Scaffolding Proteins:
YWHAB YWHAE YWHAQ YWHAZ

 

List of LncRNAs

The LncRNAs collected for the mouse Hippo pathway are listed in Table 1. Click an LncRNA accession number to see its detailed information and its potential target gene(s) in the Hippo pathway.

Table 1. Mouse Hippo pathway focuse LncRNAs

ENSMUST00000032594, ENSMUST00000092369, ENSMUST00000105060, Hipk2, ENSMUST00000117905, ENSMUST00000121061, Hhat, Bcl11a, ENSMUST00000125440, ENSMUST00000127079, ENSMUST00000127313, ENSMUST00000128067, Mapk7, ENSMUST00000128607, Cngb1, ENSMUST00000135110, Fgf2, ENSMUST00000139612, ENSMUST00000140071, ENSMUST00000140185, ENSMUST00000140955, ENSMUST00000141076, ENSMUST00000141128, ENSMUST00000141833, ENSMUST00000146690, ENSMUST00000150734, ENSMUST00000152754, ENSMUST00000153578, ENSMUST00000153730, ENSMUST00000153740, ENSMUST00000153961, ENSMUST00000154062, ENSMUST00000159478, ENSMUST00000159507, ENSMUST00000161139, Atrip, ENSMUST00000163068, ENSMUST00000164035, Adrbk1, ENSMUST00000165185, ENSMUST00000174338, Pou6f2, ENSMUST00000176764, ENSMUST00000180901, ENSMUST00000181247, ENSMUST00000182050, 

Full List of Mouse Hippo Pathway Focused LncRNAs.pdf

Gene List

The potential gene targets of mouse Hippo pathway focus LncRNAs are listed in Table 2. Click the protein gene names to see the detailed information about the genes and their corresponding regulatory LncRNAs in the Hippo pathway.

Table 2. Functional gene grouping

Hippo Core Kinase Complex:
Lats2 Mob1b Mob1a Mst1 Stk4 Sav1 Stk3 Stk4 Taz Wwtr1 Yap1
Downstream Mediators:
Hipk2 Mapk10 Meis1 Prkci Prkcz Smad1 Tead1 Tead2 Tead3 Tead4 Trp63 Tshz1 Tshz2 Tshz3 Wnt1
Contact Inhibition:
Nf2 Taz Yap1
Target Genes:
Casp3 Ccne1 Ccne2 Myc Ppp2cb Ppp2r1a Ppp2r2d Ptpn14 Rere
Upstream Regulators:
Actg1 Amot Amotl1 Amotl2 Casp3 Crb1 Crb2 Crb3 Csnk1d Csnk1e Dchs1 Diap2 Dlg1 Dvl2 Fat1 Fat2 Fat3 Fat4 Fjx1 Jub Limd1 Lix1l Llgl1 Llgl2 Lpp Nf2 Rassf4 Scrib Wtip Wwc1 Zdhhc18
Cell Polarity:
Crb1 Crb2 Crb3 Dchs1 Fat1 Fat2 Fat3 Fat4 Gpc5 Hmcn1 Lats1 Lats2 Mpdz Mpp5 Mst1 Stk4 Nphp4 Pard3 Pard6g Scrib Stk3 Stk4 Taok1 Taok2 Taok3 Tjp1 Tjp2
Target genes:
Areg Birc5 Ctgf Jub Gna12 Gna13 Gnai1 Gnai2 Gnai3 Gnaq Hipk2 Ppp2r4 Rho Taz Tead1 Tead2 Tead3 Tead4 Wbp2 Ywhaq Amot Csnk1a1 Crb3 Cdh1 Wwc1 Lats1 Lats2 Stk4 Stk3 Nf2 Sgms1 Mpp5 Inadl Ptpn14 Rassf1 Rassf2 Rassf3 Rassf4 Rassf5 Sav1 Scrib Taok1 Frmd6 Btrc
Key Components of Hippo Signaling Pathway:
Cd44 Crb1 Crb2 Crb3 Dchs1 Cdh1 Fat4 Lats1 Lats2 Mob1a Mob1b Mst1 Stk4 Stk3 Sav1 Taz Csnk1d Csnk1e Fjx1 Lix1 Lix1l Zdhhc14 Zdhhc18 Zdhhc9 Zyx Jub Amot Prkci Prkcz Dlg1 Wwc1 Llgl1 Llgl2 Limd1 Nf2 Mpp5 Pard3 Pard6a Ptpn14 Scrib Frmd6 Wtip Tjp1 Tjp2 Ctnna1 Ctnnb1 Ywhaq Ppp1r13b Itch Ppp2r4 Rassf1 Rassf2 Rassf3 Rassf4 Rassf5 Rassf6 Taok1 Taok2 Taok3 Btrc Trp63 Meis1 Meis2 Meis3 Trp73 Pax3 Pparg Pknox1 Pknox2 Runx2 Tbx5 Tead1 Tead2 Tead3 Tead4 Tshz1 Tshz2 Tshz3 Nkx2-1 Wbp2 Afp Areg Birc2 Birc5 Ccnd1 Cdx2 Ctgf Ccne1 Cyr61 Diap1 E2f1 Fgf1 Fgf2 Gli2 Itgb2 Smad7 Lats2 Mob1b Mob1a Mst1 Stk4 Sav1 Stk3 Stk4 Taz Wwtr1 Yap1 Rassf5 Raf1 Terf2ip Hras1 Kras Nras Rassf1 Rassf2 Rassf3 Rassf4 Rassf5 Rassf6 Amot Aurka Wwc1 Stk3 Mob1a Mst1 Stk4 Ywhaq Amot Amotl1 Amotl2 Csnk1d Csnk1e Lats1 Lats2 Kitl Tjp2 Ctnna1 Btrc Foxo1 Foxo3 Lats1 Lats2 Mob1a Ndrg1 Stk38l Sav1 Taz Trp73 Pax3 Pparg Runx2 Smad2 Smad3 Smad4 Tbx5 Tead1 Tead2 Tead3 Tead4 Nkx2-1
Scaffolding Proteins:
Ywhab Ywhae Ywhaq Ywhaz