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  • Human Database
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Product NameCatalog NoDescriptionFormatPrice
LncPath™ Mouse Hedgehog Pathway Microarray AS-LP-002M 512 LncRNAs and 372 their potential coding targets 8*15K
LncPath™ Human Hedgehog Pathway Microarray AS-LP-002H 802 LncRNAs and 226 their potential coding targets 8*15K

The Hedgehog (Hh) pathway is a major regulator of many fundamental processes in vertebrate embryonic development including stem cell maintenance, cell differentiation, tissue polarity and cell proliferation. Inappropriate activation of the Hh pathway has been associated with a variety of human cancers [1, 2].

The LncPath™ Human Hedgehog Pathway Microarray simultaneously profiles the expression of 802 LncRNAs and 226 of the potential coding genes related to the Hedgehog signaling pathway. The LncPath™ Mouse Hedgehog Pathway Microarray simultaneously profiles the expression of 512 LncRNAs and 372 of the potential coding genes related to the Hedgehog signaling pathway. All the LncRNAs and their potential target genes that are associated with the Hedgehog pathway have been carefully selected from authoritative databases and landmark literatures using a very rigorous screening process. This pre-designed panel is a powerful tool used to quickly generate expression data for both LncRNAs and their potential gene targets in the Hedgehog signaling pathway, thereby providing comprehensive insights into the underlying regulatory mechanisms of the LncRNAs found in the Hedgehog pathway.

Reliable Hedgehog pathway focus lncRNA collection
Simultaneous analysis of LncRNAs and their potential coding gene targets related to the Hedgehog pathway
Efficient and robust labeling system
Innovative probe design
Guaranteed performance

An example showing the detailed information about the LncRNAs and their potential coding gene targets

Click the LncRNA accession number, you will see the figures showing the detailed information about LncRNA and its potential target gene.


Figure 1. The genomic map views of the LncRNA ENST00000472619 and its potential target gene ADAM17. From the top to the bottom of the figure 1, the following items are displayed:
Genome view: A chromosome ideogram showing the map position of the LncRNA ENST00000472619 and its potential target gene ADAM17 (red bar).
Map view ruler: The map coordinates of the human genome assembly hg19 for the map views below.
LncRNA map view: The LncRNAs whose genes located at or near the ADAM17 gene are presented in the Noncoding panel (shaded blue). The LncRNAs are indicated by the transcript IDs, the exons by solid blocks, the introns by thin lines, and the transcription directions by arrows. The exons of LncRNA ENST00000472619 are labeled in red, while the exons of the other LncRNAs are labeled in blue.
Coding gene map view: The coding gene ADAM17 is presented in the Coding panel (shaded green). The coding gene is indicated by its canonical transcript ID, the exons by solid blocks, the introns by thin lines and the transcription direction by arrows.


Figure 2. The relationship between LncRNA ENST00000472619 and its protein coding gene target ADAM17. The other neighboring LncRNAs which may regulate ADAM17 expression are also shown.


Figure 3. The LncRNA uc001gyv.1 may function as a competing endogenous RNA (ceRNA) of the protein coding gene ADAM17.
* MuTaMe Score, Mutually Targeted MRE Enrichment Score [3].

References1.   Gupta, S., N. Takebe and P. Lorusso, Targeting the Hedgehog pathway in cancer. Ther Adv Med Oncol, 2010. 2(4): p. 237-50.
2.    Rubin, L.L. and F.J. de Sauvage, Targeting the Hedgehog pathway in cancer. Nat Rev Drug Discov, 2006. 5(12): p. 1026-33.
3.   Tay, Y., et al., Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs. Cell, 2011. 147(2): p. 344-57.

LncRNA List
The human Hedgehog pathway LncRNAs are listed in Table 1. Click the LncRNA accession numbers to see the detailed information about the LncRNAs and their potential coding gene targets in the Hedgehog pathway.

Table 1. Human Hedgehog pathway focused LncRNAs

ENST00000279573, ENST00000292144, ENST00000331871, ENST00000356672, ENST00000379963, ENST00000381361, ENST00000411473, ENST00000412013, ENST00000412069, ENST00000412638, ENST00000412817, ENST00000417130, ENST00000417589, ENST00000417672, ENST00000419225, ENST00000419531, ENST00000419682, ENST00000420356, ENST00000420452, ENST00000421083, ENST00000421298, ENST00000421734, ENST00000422494, ENST00000422894, ENST00000423237, ENST00000423714, ENST00000424191, ENST00000424739, ENST00000424779, ENST00000425371, ENST00000426409, ENST00000426577, ENST00000427278, ENST00000429224, ENST00000431165, ENST00000431343, ENST00000433033, ENST00000434147, ENST00000436097, ENST00000436329, ENST00000436355, ENST00000437203, ENST00000437793, ENST00000438468, ENST00000438622, ENST00000439180, ENST00000439378, ENST00000439501, ENST00000440453, ENST00000440965, 

Full List of Human Hedgehog Pathway Focused LncRNAs.pdf

Gene List
The potential gene targets of human Hedgehog pathway focus LncRNAs are listed in Table 2. Click the protein gene names to see the detailed information about the genes and their corresponding regulatory LncRNAs in the Hedgehog pathway.

Table 2. Functional gene grouping

Intracellular signal transducers:
CSNK1A1 GSK3B PRKACA PRKACB PRKACG SMO SUFU BTRC
Wnt Signaling Pathway Wnt receptors:
FZD1 FZD10 FZD2 FZD3 FZD4 FZD5 FZD6 FZD7 FZD8 FZD9 LDLR LRP5 LRP6 SFRP1 SFRP2 SMO
Downregulation target genes by Hedgehog pathway:
AMH DBX1 DBX2 IRX3 IVL KRT1 KRT10 LOR PAX6 PAX7
Regulation of receptors binding Positive regulation:
BOC CDON LRP2 NPC1
Wnt Signaling Pathway Main target genes:
AXIN2 BMP4 CCND1 CD44 PTGS2 FOSL1 ID2 JUN MYC NCAM1 NKD1 PGP PPARA HNF1A VEGFA
Wnt Signaling Pathway Wnt ligands:
WNT1 WNT10A WNT10B WNT11 WNT16 WNT2 WNT2B WNT3 WNT3A WNT4 WNT5A WNT5B WNT6 WNT7A WNT7B WNT8A WNT8B WNT9A WNT9B
Wnt Signaling Pathway Intracellular signal transducers:
ANAPC1 SLC25A24 APC2 ARRB2 AXIN1 AXIN2 BTRC CSNK1A1 CTNNB1 DVL1 DVL1 DVL2 DVL3 GSK3A GSK3B
Notch Signaling Pathway Notch ligands:
DLL1 DLL3 DLL4 JAG1 JAG2
Notch Signaling Pathway Intracellular signal transducers:
ADAM10 ADAM17 APH1A APH1B DTX1 DTX2 DTX3 DTX3L DTX4 DVL1 DVL2 DVL3 ITCH NCSTN NEDD4 NUMB NUMBL PSEN1 PSEN2 PSENEN
Regulation of receptors binding Other regulators involved:
CCNB1 CDK1 NPC1L1 PTCHD1 RNF139 WIF1
Hedgehog receptors:
PTCH1 PTCH2
Transcription factors:
GLI1 GLI2 GLI3
Hedgehog Pathway in Cancer:
DHH DZIP1 DZIP1L BTRC FBXW11 GLI1 GLI2 GLI3 HHAT HHIP IHH KIF27 KIF7 PTCH1 PTCH2 SHH SMO STK36 SUFU
Hedgehog ligands:
DHH IHH SHH
Notch Signaling Pathway Transcription factors:
RBPJ RBPJ
Regulation of Intracellular signal transduction Other regulators involved:
DZIP1 DZIP1L IFT172 IFT88 KIF27 KIF4A KIF7 RBX1 STIL
Notch Signaling Pathway Notch receptors:
NOTCH1 NOTCH2 NOTCH3 NOTCH4
Regulation of ligands secretion Other regulators involved:
EN1 EN2 EXTL1 EXTL2 EXTL3 EXTL1 GPC1 GPC4 GPC5 GPC6 NDST2
Regulation of transcriptional activity Negative regulation:
AKT1 BTRC CSNK1A1 CUL3 DYRK2 FBXW11 GLI3 GSK3B KCTD11 NUMB PRKACA PRKACB PRKACG SKI SPOP TTC21B
Regulation of ligands secretion Negative regulation:
GPC3 HHIP
Regulation of Intracellular signal transduction Positive regulation:
ARRB1 ARRB2 ADRBK1 KIF3A SMO STK36
Wnt Signaling Pathway Transcription factors:
LEF1 HNF1A TCF4 TCF7L1
Notch Signaling Pathway Main target genes:
CDKN1A HES1 HEY1 MYC
Regulation of receptors binding Negative regulation:
FKBP8 GAS1 PTCH1 PTCH2
Main target genes:
BCL2 BMI1 CCND2 FOXM1 GLI1 HHIP JAG2 MYC PTCH1 SFRP1
Regulation of Intracellular signal transductionNegative regulation:
RAB23 SAP18 SIN3A SUFU
Regulation of transcriptional activity Other regulators involved:
CUL1 CUL2 DYNC2H1 UBR5 GLI4
Upregulation target genes by Hedgehog pathway:
ANGPT1 ANGPT2 BCL2 FOXG1 BMI1 BMP4 CCNA2 CCNB1 CCND1 CCND2 CCNE1 CDK1 CDC45 CDK1 CDON CFLAR COL10A1 E2F1 E2F2 FOXC2 FOXF1 FOXL1 FOXM1 FST TSC22D3 GLI1 HHIP FOXA2 IGF2 IHH JAG2 LASP1 MDM2 MYC MYF5 NKX2-2 NKX6-1 NKX6-2 MYCN NR4A1 OLIG1 OLIG2 PDGFRA PMP22 PTCH1 PTCH2 PTHLH SFRP1 SFRP2 SMO SNAI1 SNAI2 SPOP THBD TNFSF11 TWIST2 VEGFA WNT2B WNT5A ZEB1 ZEB2
Regulation of transcriptional activity Positive regulation:
CDK11B CREBBP DYRK1A GLI1 GLI2 MAP3K10 MAP2K1 MTSS1 PRKCD ZIC2
Regulation of ligands secretion Positive regulation:
DHH DISP1 DISP2 PTCHD2 EXT1 EXT2 HHAT IHH SHH

LncRNA List
The mouse Hedgehog pathway LncRNAs are listed in Table 1. Click the LncRNA accession numbers to see the detailed information about the LncRNAs and their potential coding gene targets in the Hedgehog pathway.

Table 1. Mouse Hedgehog pathway focused LncRNAs

ENSMUST00000091324, ENSMUST00000092369, ENSMUST00000105060, ENSMUST00000118288, ENSMUST00000119987, ENSMUST00000120814, ENSMUST00000121061, ENSMUST00000124166, ENSMUST00000124439, ENSMUST00000125440, ENSMUST00000125567, ENSMUST00000125917, ENSMUST00000126472, ENSMUST00000127003, ENSMUST00000127079, ENSMUST00000128067, ENSMUST00000128182, ENSMUST00000128654, ENSMUST00000130777, ENSMUST00000133528, ENSMUST00000134324, ENSMUST00000134673, ENSMUST00000135485, ENSMUST00000135522, ENSMUST00000136300, ENSMUST00000136555, ENSMUST00000137394, ENSMUST00000141358, ENSMUST00000143363, ENSMUST00000145106, ENSMUST00000145411, ENSMUST00000145954, ENSMUST00000146587, ENSMUST00000146690, ENSMUST00000147092, ENSMUST00000147929, ENSMUST00000148315, ENSMUST00000148683, ENSMUST00000150442, ENSMUST00000150734, 

Full List of Mouse Hedgehog Pathway Focused LncRNAs.pdf

Gene List
The potential gene targets of mouse Hedgehog pathway focus LncRNAs are listed in Table 2. Click the protein gene names to see the detailed information about the genes and their corresponding regulatory LncRNAs in the Hedgehog pathway.

Table 2. Functional gene grouping

Intracellular signal transducers:
Csnk1a1 Gsk3b Prkaca Prkacb Smo Sufu Btrc
Wnt Signaling Pathway Wnt receptors:
Fzd1 Fzd10 Fzd2 Fzd3 Fzd4 Fzd5 Fzd6 Fzd7 Fzd8 Fzd9 Ldlr Lrp5 Lrp6 Sfrp1 Sfrp2 Smo
Downregulation target genes by Hedgehog pathway:
Amh Dbx1 Dbx2 Irx3 Ivl Krt1 Krt10 Lor Pax6 Pax7
Regulation of receptors binding Positive regulation:
Boc Cdon Lrp2 Npc1
Wnt Signaling Pathway Main target genes:
Axin2 Bmp4 Ccnd1 Cd44 Ptgs2 Fosl1 Id2 Jun Myc Ncam1 Nkd1 Pgp Ppara Hnf1a Vegfa
Wnt Signaling Pathway Wnt ligands:
Wnt1 Wnt10a Wnt10b Wnt11 Wnt16 Wnt2 Wnt2b Wnt3 Wnt3a Wnt4 Wnt5a Wnt5b Wnt6 Wnt7a Wnt7b Wnt8a Wnt8b Wnt9a Wnt9b
Wnt Signaling Pathway Intracellular signal transducers:
Anapc1 Slc25a24 Apc2 Arrb2 Axin1 Axin2 Btrc Csnk1a1 Ctnnb1 Dvl1 Dvl1 Dvl2 Dvl3 Gsk3a Gsk3b
Notch Signaling Pathway Notch ligands:
Dll1 Dll3 Dll4 Jag1 Jag2
Notch Signaling Pathway Intracellular signal transducers:
Adam10 Adam17 Aph1a Aph1b Dtx1 Dtx2 Dtx3 Dtx3l Dtx4 Dvl1 Dvl2 Dvl3 Itch Ncstn Nedd4 Numb Numbl Psen1 Psen2 Psenen
Regulation of receptors binding Other regulators involved:
Cdk1 Npc1l1 Ptchd1 Rnf139 Wif1
Hedgehog receptors:
Ptch1 Ptch2
Transcription factors:
Gli1 Gli2 Gli3
Hedgehog Pathway in Cancer:
Dhh Dzip1 Dzip1l Btrc Fbxw11 Gli1 Gli2 Gli3 Hhat Hhip Ihh Kif27 Kif7 Ptch1 Ptch2 Shh Smo Stk36 Sufu
Hedgehog ligands:
Dhh Ihh Shh
Notch Signaling Pathway Transcription factors:
Rbpj Rbpj
Regulation of Intracellular signal transduction Other regulators involved:
Dzip1 Dzip1l Ift172 Ift88 Kif27 Kif4 Kif7 Stil
Notch Signaling Pathway Notch receptors:
Notch1 Notch2 Notch3 Notch4
Regulation of ligands secretion Other regulators involved:
En1 En2 Extl1 Extl2 Extl3 Extl1 Gpc1 Gpc4 Gpc5 Gpc6 Ndst2
Regulation of transcriptional activity Negative regulation:
Akt1 Btrc Csnk1a1 Cul3 Dyrk2 Fbxw11 Gli3 Gsk3b Kctd11 Numb Prkaca Prkacb Ski Spop Ttc21b
Regulation of ligands secretion Negative regulation:
Gpc3 Hhip
Regulation of Intracellular signal transduction Positive regulation:
Arrb1 Arrb2 Adrbk1 Kif3a Smo Stk36
Wnt Signaling Pathway Transcription factors:
Lef1 Hnf1a Tcf4 Tcf7l1
Notch Signaling Pathway Main target genes:
Cdkn1a Hes1 Hey1 Myc
Regulation of receptors binding Negative regulation:
Fkbp8 Gas1 Ptch1 Ptch2
Main target genes:
Bcl2 Ccnd2 Foxm1 Gli1 Hhip Jag2 Myc Ptch1 Sfrp1
Regulation of Intracellular signal transductionNegative regulation:
Rab23 Gm10094 Sap18 Sin3a Sufu
Regulation of transcriptional activity Other regulators involved:
Cul1 Cul2 Dync2h1 Ubr5
Upregulation target genes by Hedgehog pathway:
Angpt1 Angpt2 Bcl2 Foxg1 Bmp4 Ccna2 Ccnd1 Ccnd2 Ccne1 Cdk1 Cdc45 Cdk1 Cdon Cflar Col10a1 E2f1 E2f2 Foxc2 Foxf1 Foxl1 Foxm1 Fst Tsc22d3 Gli1 Hhip Foxa2 Igf2 Ihh Jag2 Lasp1 Mdm2 Myc Myf5 Nkx2-2 Nkx6-1 Nkx6-2 Mycn Nr4a1 Olig1 Olig2 Pdgfra Pmp22 Ptch1 Ptch2 Pthlh Sfrp1 Sfrp2 Smo Snai1 Snai2 Spop Thbd Tnfsf11 Twist2 Vegfa Wnt2b Wnt5a Zeb1 Zeb2
Regulation of transcriptional activity Positive regulation:
Cdk11b Crebbp Dyrk1a Gli1 Gli2 Map3k10 Map2k1 Mtss1 Prkcd Zic2
Regulation of ligands secretion Positive regulation:
Dhh Disp1 Disp2 Ptchd2 Ext1 Ext2 Hhat Ihh Shh