The Hedgehog (Hh) pathway is a major regulator of many fundamental processes in vertebrate embryonic development including stem cell maintenance, cell differentiation, tissue polarity and cell proliferation. Inappropriate activation of the Hh pathway has been associated with a variety of human cancers [1, 2].
The LncPath™ Human Hedgehog Pathway Microarray simultaneously profiles the expression of 802 LncRNAs and 226 of the potential coding genes related to the Hedgehog signaling pathway. The LncPath™ Mouse Hedgehog Pathway Microarray simultaneously profiles the expression of 512 LncRNAs and 372 of the potential coding genes related to the Hedgehog signaling pathway. All the LncRNAs and their potential target genes that are associated with the Hedgehog pathway have been carefully selected from authoritative databases and landmark literatures using a very rigorous screening process. This pre-designed panel is a powerful tool used to quickly generate expression data for both LncRNAs and their potential gene targets in the Hedgehog signaling pathway, thereby providing comprehensive insights into the underlying regulatory mechanisms of the LncRNAs found in the Hedgehog pathway.
• Reliable Hedgehog pathway focus lncRNA collection
• Simultaneous analysis of LncRNAs and their potential coding gene targets related to the Hedgehog pathway
• Efficient and robust labeling system
• Innovative probe design
• Guaranteed performance
An example showing the detailed information about the LncRNAs and their potential coding gene targets
Click the LncRNA accession number, you will see the figures showing the detailed information about LncRNA and its potential target gene.
Figure 1. The genomic map views of the LncRNA ENST00000472619 and its potential target gene ADAM17. From the top to the bottom of the figure 1, the following items are displayed:
Genome view: A chromosome ideogram showing the map position of the LncRNA ENST00000472619 and its potential target gene ADAM17 (red bar).
Map view ruler: The map coordinates of the human genome assembly hg19 for the map views below.
LncRNA map view: The LncRNAs whose genes located at or near the ADAM17 gene are presented in the Noncoding panel (shaded blue). The LncRNAs are indicated by the transcript IDs, the exons by solid blocks, the introns by thin lines, and the transcription directions by arrows. The exons of LncRNA ENST00000472619 are labeled in red, while the exons of the other LncRNAs are labeled in blue.
Coding gene map view: The coding gene ADAM17 is presented in the Coding panel (shaded green). The coding gene is indicated by its canonical transcript ID, the exons by solid blocks, the introns by thin lines and the transcription direction by arrows.
Figure 2. The relationship between LncRNA ENST00000472619 and its protein coding gene target ADAM17. The other neighboring LncRNAs which may regulate ADAM17 expression are also shown.
Figure 3. The LncRNA uc001gyv.1 may function as a competing endogenous RNA (ceRNA) of the protein coding gene ADAM17.
* MuTaMe Score, Mutually Targeted MRE Enrichment Score .
References1. Gupta, S., N. Takebe and P. Lorusso, Targeting the Hedgehog pathway in cancer. Ther Adv Med Oncol, 2010. 2(4): p. 237-50.
2. Rubin, L.L. and F.J. de Sauvage, Targeting the Hedgehog pathway in cancer. Nat Rev Drug Discov, 2006. 5(12): p. 1026-33.
3. Tay, Y., et al., Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs. Cell, 2011. 147(2): p. 344-57.
The mouse Hedgehog pathway LncRNAs are listed in Table 1. Click the LncRNA accession numbers to see the detailed information about the LncRNAs and their potential coding gene targets in the Hedgehog pathway.
Table 1. Mouse Hedgehog pathway focused LncRNAs
ENSMUST00000091324, ENSMUST00000092369, ENSMUST00000105060, ENSMUST00000118288, ENSMUST00000119987, ENSMUST00000120814, ENSMUST00000121061, ENSMUST00000124166, ENSMUST00000124439, ENSMUST00000125440, ENSMUST00000125567, ENSMUST00000125917, ENSMUST00000126472, ENSMUST00000127003, ENSMUST00000127079, ENSMUST00000128067, ENSMUST00000128182, ENSMUST00000128654, ENSMUST00000130777, ENSMUST00000133528, ENSMUST00000134324, ENSMUST00000134673, ENSMUST00000135485, ENSMUST00000135522, ENSMUST00000136300, ENSMUST00000136555, ENSMUST00000137394, ENSMUST00000141358, ENSMUST00000143363, ENSMUST00000145106, ENSMUST00000145411, ENSMUST00000145954, ENSMUST00000146587, ENSMUST00000146690, ENSMUST00000147092, ENSMUST00000147929, ENSMUST00000148315, ENSMUST00000148683, ENSMUST00000150442, ENSMUST00000150734,
Full List of Mouse Hedgehog Pathway Focused LncRNAs.pdf
The potential gene targets of mouse Hedgehog pathway focus LncRNAs are listed in Table 2. Click the protein gene names to see the detailed information about the genes and their corresponding regulatory LncRNAs in the Hedgehog pathway.
Table 2. Functional gene grouping