• Description
  • Highlights
  • Human Database
  • Mouse Database
Product NameCatalog NoDescriptionFormatPrice
LncPath™ Human Apoptosis Pathway Microarray AS-LP-010H 1,451 LncRNAs and 514 their potential coding targe 8*15K
LncPath™ Mouse Apoptosis Pathway Microarray AS-LP-010M 817 LncRNAs and 856 their potential coding targets 8*15K

Apoptosis is a form of programmed cell death that plays an important role in cell and tissue homeostasis and in growth control. The proper regulation of apoptosis is essential for the survival of multicellular organisms, and deregulation of this process is associated with a wide variety of human diseases including cancer, neurodegeneration diseases, cardiovascular disorders and autoimmune diseases. The molecular mechanisms behind apoptosis are not fully understood. Recent research has suggested the essential roles of LncRNAs in the regulation of apoptosis.

The LncPath™ Human Apoptosis Pathway LncRNA Microarray simultaneously profiles the expression of 1,451 LncRNAs and 514 their potential coding targets related to the apoptosis signaling pathway. The LncPath™ Mouse Apoptosis Pathway LncRNA Microarray simultaneously profiles the expression of 817 LncRNAs and 856 their potential coding targets related to the apoptosis signaling pathway. The LncRNAs whose genes are located at or near the protein-coding genes critical in the apoptosis pathway, and the LncRNAs that have high possibilities of being competing endogenous RNAs (ceRNAs) of the key apoptosis genes, are carefully collected from authoritative databases using rigorous selection processes. By focusing on the LncRNAs most relevant to the apoptosis pathway, the array can achieve much faster and more precise analysis, due to the highly specific yet smaller amount of data to analyze. More importantly, it can establish the expressional relationships between the LncRNAs and their protein-coding gene targets involved in the apoptosis signaling pathway, thereby providing comprehensive insights into the underlying regulatory mechanisms of LncRNAs in apoptosis.

Comprehensive and reliable collection of apoptosis pathway focused LncRNAs.

Simultaneous analysis of LncRNAs and their protein-coding gene targets in the apoptosis pathway.

Explore and establish expressional relationships and regulatory mechanisms between the LncRNAs and the target pathway genes.

Faster and more precise pathway-focused analysis.

Efficient and robust labeling system.

Innovative probe design.

Guaranteed performance.

An example showing the detailed information about the LncRNAs and their potential coding gene target

Click the LncRNA accession number listed in databases, you will see the figures showing the detailed information about the LncRNAs and their potential target gene.

BCL2L1

Figure 1. The genomic map views of the LncRNA ENST00000412972 and its potential target gene BCL2L1. From the top to the bottom of the figure 1, the following items are displayed:

Genome view: A chromosome ideogram showing the map position of the LncRNA ENST00000412972 and its potential target gene BCL2L1 (red bar).

Map view ruler: The map coordinates of the human genome assembly hg19 for the map views below.

LncRNA map view: The LncRNAs whose genes located at or near the BCL2L1 gene are presented in the Noncoding panel (shaded green). The LncRNAs are indicated by the transcript IDs, the exons by solid blocks, the introns by thin lines, and the transcription directions by arrows. The exons of LncRNA ENST00000412972 are labeled in red, while the exons of the other LncRNAs are labeled in blue.

Coding gene map view: The coding gene BCL2L1 is presented in the Coding panel (shaded blue). The coding gene is indicated by its canonical transcript ID, the exons by solid blocks, the introns by thin lines, and the transcription direction by arrows.

BCL2L1-2

Figure 2. The relationship between LncRNA ENST00000412972 and its protein coding gene target BCL2L1. The other neighboring LncRNAs which may regulate BCL2L1 expression are also shown.

BCL2L1-3

Figure 3. The LncRNA ENST00000566270 may function as a competing endogenous RNA (ceRNA) of the protein coding gene BCL2L1.

* MuTaMe Score, Mutually Targeted MRE Enrichment Score [1].

References
1.Tay, Y., et al. (2011) Cell 147 (2): 344-57.

List of LncRNAs

The LncRNAs collected for human apoptosis pathway are listed in Table 1. Click an LncRNA accession number to see its detailed information and its potential target gene(s) in the apoptosis pathway.

Table 1. Human apoptosis pathway focused LncRNAs

ENST00000279573, ENST00000312310, ENST00000321326, ENST00000333854, ENST00000339626, ENST00000357401, ENST00000359823, ENST00000366413, ENST00000374207, ENST00000381143, ENST00000393647, ENST00000407054, ENST00000411427, ENST00000412173, ENST00000412638, ENST00000412776, ENST00000412914, ENST00000412972, ENST00000413053, ENST00000413234, ENST00000414190, ENST00000415236, ENST00000415589, ENST00000415890, ENST00000416146, ENST00000416554, ENST00000416860, ENST00000417058, ENST00000417123, ENST00000417941, ENST00000419531, ENST00000419609, ENST00000419973, ENST00000420672, ENST00000421055, ENST00000421411, ENST00000422040, ENST00000422703, ENST00000422822, ENST00000423120, ENST00000423194, ENST00000423763, ENST00000424339, ENST00000424487, ENST00000424531, ENST00000424664, ENST00000424739, ENST00000425022, ENST00000425371, ENST00000425750, 

Full list of Human Apoptosis Pathway Focused LncRNAs.pdf

Gene List

The potential gene targets of human apoptosis pathway focus LncRNAs are listed in Table 2. Click the protein gene names to see the detailed information about the genes and their corresponding regulatory LncRNAs in the apoptosis pathway.

Table 2. Functional gene grouping

Caspases:
CASP10 CASP2 CASP8 CASP9 CASP3 CASP6 CASP7
Adaptor proteins of Apoptosome:
APAF1
BCL2 and BAG Domain:
BAG1 BAG3 BAG4 BAX BCL2 BCL2A1 BCL2L1 BCL2L10 BCL2L13 BCL2L2 MCL1
IAP antagonists:
DIABLO HIBADH GSPT1 CSF2 GSPT1 IL3 IL5 HTRA2 DIABLO DIABLO XAF1
Apoptosis-related Phosphorylation/Dephosphorylation:
AKT1 ABL1 CAMK2A CDK1 CSNK2A1 PRKDC DYRK1A MAPK3 MAPK1 FYN LYN MAPK1 MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPK7 MAPK8 MAPK9 MAPK14 PRKACA PRKACB PRKACG PRKCD PPA1 PPP1CA PPP2CA PPP2R4 PTPN6 SRC AKT1 ATM CSNK2A1 CDK1 MAPK3 MAPK1 GSK3B MAPK8 MAPK14 RPS6KB1 RPS6KA1 PAK1 PIM1 PRKACA PRKACB PRKACG PRKCZ PPP2CA PPP2R4 RPS6KA1 RPS6KA3
Regulators of BCL2 family Transcriptional repressors:
KCNIP3 BMI1 TP63 SNAI2 TP63 TP73
Adaptor proteins of death-inducing signalling complex (DISC) :
CFLAR FADD RIPK1 TRADD
Caspases & Regulators:
CARD17 CARD18 CASP1 CASP10 CASP14 CASP2 CASP3 CASP4 CASP5 CASP6 CASP7 CASP8 CASP9 CFLAR CRADD MALT1 PYCARD RFWD2 AIFM3 APAF1 BAX BBC3 BCL2L10 BCL2L13 CASP1 CASP8AP2 CASP9 COL4A3 CYCS DIABLO EIF2AK3 F2 F2R FOXL2 HIP1 HSPE1 IFNB1 IFT57 LCK MAP3K5 MOAP1 MTCH1 MYC NLRC4 NLRP1 NLRP12 NLRP2 NLRP3 NOD1 PMAIP1 PYCARD STAT1 TNFRSF10A TNFRSF10B TNFSF15 TP53 TPD52L1 VCP BIRC5 CD27 DHCR24 IFI6 SFN TNFAIP8 TNFSF14 TRIAP1 XIAP
Regulators of BCL2 family Kinases:
AKT1 CDK1 MAPK8 RPS6KB1 RPS6KA1 PAK1 PIM1 PRKACA PRKACB PRKACG ATM CSNK2A1 MAPK8 MAPK3 MAPK1 MAPK8 RPS6KA1 RPS6KA3 CSNK2A1 MAPK3 MAPK1 MAPK8 MAPK8 MAPK3 MAPK1 GSK3B MAPK8 AKT1 MAPK3 MAPK1 GSK3B MAPK8 MAPK14 PRKCZ PPP2CA PPP2R4
Death ligands of TNF superfamily:
TNFRSF9 TNFSF13 CD70 TNFSF8 CD40LG EDA EDA EDA FASLG FASLG TNFSF18 TNFSF14 LTA LTB TNFSF4 TNFSF11 TNFSF13B TNF TNFSF10 TNFSF14 TNFSF15 TNFSF8 TNFSF10 TNFSF12
Apoptosis-related Ubiquitin and Deubiquitin:
BIRC2 BIRC3 FBXW7 ITCH MDM2 HUWE1 SIAH1 SIAH2 VHL XIAP BTRC CASP3 CASP7 BIRC2 BIRC3 CFLAR HIF1A HIPK2 NFKBIA JUN MCL1 MYC MAP3K14 TP53 TP63 EGLN2 EGLN3 RALBP1 RIPK1 UQCRFS1 DIABLO TRAF2 XIAP TNFAIP3 CYLD USP14 USP7 USP9X BCL3 CASP8 FOXO4 MALT1 MDM2 MDM4 IKBKG TP53 PTEN RALBP1 RIPK1 UQCRFS1 RIPK2 TGFB1 TGFB2 TGFB3 TRAF2 TRAF6 UBE2N UBE2D1 CTNNB1
Anti-apoptotic members:
BCL2 BCL2A1 BCL2L1 BCL2L2 MCL1 BCL2L10
TNF Domain:
EDA FASLG LTA LTB TNF TNFSF10 TNFSF14 TNFSF15 TNFSF8
Regulators of BCL2 family Ubiquitinylase:
BTRC HUWE1 PMAIP1 BTRC
Kinases/Phosphatases targeted by Caspases:
AKT1 ALK BMX ABL1 CAMK4 CAMKK2 EGFR ERBB2 EPHA3 PTK2 FYN ERBB2 HIPK2 MAP4K1 CHUK MAPK8 LYN ANKHD1 MAP3K1 MET MST1 STK4 STK3 STK24 MST4 RPS6KB1 PAK2 PDGFRB PHKA2 PIP5K1A PRKCD PRKCE PRKCZ PRKCH PRKCQ PKN1 PKN2 EIF2AK2 PKN1 PKN2 RAF1 RET RALBP1 RIPK1 UQCRFS1 RIPK3 ROCK1 SLK SRC SRPK1 SRPK2 ATM BUB1 BUB1B CHEK1 CCNB1 CCNE1 PRKDC CDK11B WEE1 CDC25A PPP2CA PPP2R4 PTEN PTPN12
Induction of Apoptosis:
BID CRADD DAXX DEDD2 FADD IL18 TNF TNFRSF10B ABL1 AIFM1 BCL3 BRCA1 CHEK2 CIDEA CIDEB DYRK2 IFI16 MBD4 MSH6 PCBP4 PML SFN TP53 TP73 GPX1 PRODH RNF7 TP53I3 ADORA1 BTK CASP8AP2 CD28 CD38 CD5 CFLAR DAP DAP3 DAPK1 DPF2 FASTK MAP3K5 NDUFA13 PDCD6 PRKCA RIPK3 SPN TIMP3 TNFRSF25 CDKN1A CUL1 CUL2 CUL3 CUL4A CUL5 HIPK2 MYC SART1 ACVR1B AIFM2 AIFM3 ALOX15B APOE BAD BAK1 BAX BBC3 BCL10 BCL2L11 BCL2L13 BCLAF1 BIK BNIP1 BNIP3 BNIP3L BOK CASP10 CASP3 CASP4 CASP6 CD2 CD27 CD70 CEBPB CIDEC COL4A3 DAPK2 DAPK3 DCC DDX20 DEDD DIABLO EI24 ERCC2 ERCC3 ERN1 ERN2 FAS FASLG FEM1B FOXL2 FOXO3 HRK HTATIP2 IFNA2 IFNB1 IFNG IKBIP IKBKG IL19 INHA INHBA JMY LALBA LCK LTA MAL MAP3K10 MAPK1 MX1 NDUFS3 NGFR NLRP1 NLRP3 NME3 NOTCH2 NOX5 NUDT2 NUPR1 PDCD5 PLAGL1 PLAGL2 PLEKHF1 PLG PMAIP1 PPP1R13B PPP2CA PPP2R1A PPP2R1B PRKCE PRKRA PRUNE2 PTEN PTH PYCARD RPS3A RUNX3 S100B SAP30BP SERINC3 SIPA1 SMNDC1 SST SSTR3 STK17A STK17B TBX5 TIA1 TIAL1 TLR2 TNFRSF10A TNFRSF19 TNFRSF9 TNFSF10 TNFSF14 TNFSF8 TP53BP2 TP63 TPD52L1 TRADD TRAF3 TRAIP UNC13B UTP11L ZNF443
TRAF Domain:
TRAF2 TRAF3 TRAF5 TRAF7 TRAF2 TRAF3 TRAF5 TRAF7
Apoptosis factors regulated by miRNAs:
FASLG FAF1 BBC3 BAK1 BAX BCL2 BCL2L2 BCL2L1 BCL2L11 MCL1 CASP10 CASP9 CFLAR CDKN1A PTPN13 PIK3R1 PTEN CDKN1A CDKN1B API5 CDC42 E2F1 SIRT1
Anti-Apoptosis:
BCL2L1 BRE CD28 ERC1 MAPK8IP2 OPA1 PRKAA1 RASA1 PIK3R2 RTN4 TNFAIP8 AATF AKT1 ALOX12 ANXA1 ANXA4 API5 ATF5 AVEN AZU1 BAG1 BAG3 BAG4 BCL2 BCL2A1 BCL2L1 BCL2L10 BCL2L2 BDNF BECN1 BFAR BIRC2 BIRC3 BIRC5 BIRC6 BIRC7 BIRC8 BNIP1 BNIP2 BNIP3 BRAF CASP2 CBX4 CCL2 CD27 CD40LG CEBPB CFDP1 CFL1 CFLAR CRYAA CRYAB DAD1 DDAH2 DHCR24 EEF1A2 FAIM FAIM2 FAS FOXO1 GDNF GFRAL GLO1 GSTP1 HDAC1 HDAC3 HIPK3 HMGB1 HSP90B1 HSPA1B HSPA9 HSPB1 HTATIP2 HTT IER3 IFI6 IGF1R IL10 IL1A IL2 IL31RA MALT1 MCL1 MKL1 MPO MTL5 MYBL2 MYO18A NAIP NFKB1 NME5 NOL3 NOTCH2 NPM1 NRG2 NTF3 PAK7 PAX7 PEA15 PIK3CA PIM2 POGK POLB PRDX2 PRKCZ PRLR PROK2 PSEN1 RELA RNF7 SEMA4D SERPINB2 SERPINB9 SFRP1 SH3GLB1 SNCA SOCS2 SOCS3 SON SPHK1 SPP1 STAMBP TAX1BP1 TBX3 TGFB1 TIAF1 TMX1 TNF TNFAIP3 TNFAIP8 TNFRSF10D TNFRSF18 TNFRSF6B TNFSF18 TPT1 TRIAP1 TSC22D3 VEGFA VHL XIAP YWHAZ ZC3HC1
CARD Domain:
APAF1 BCL10 BIRC2 BIRC3 CARD10 CARD11 CARD14 CARD17 CARD18 CARD6 CARD9 CASP1 CASP2 CASP4 CASP5 CASP9 CRADD NLRP1 NOD1 NOD2 NOL3 PYCARD RFWD2 RIPK2 APAF1 BCL10 BIRC2 BIRC3 CARD10 CARD11 CARD14 CARD17 CARD18 CARD6 CARD9 CASP1 CASP2 CASP4 CASP5 CASP9 CRADD NLRP1 NOD1 NOD2 NOL3 PYCARD RFWD2 RIPK2
DEATH Domain:
CRADD DAPK1 EDAR FADD MALT1 NFKB1 NFKB2 NGFR PIDD RIPK1 TNFRSF10A TNFRSF10B TNFRSF1A TNFRSF21 TNFRSF25 TRADD CRADD DAPK1 EDAR FADD MALT1 NFKB1 NFKB2 NGFR PIDD RIPK1 TNFRSF10A TNFRSF10B TNFRSF1A TNFRSF21 TNFRSF25 TRADD
TNFR Domain:
CD27 CD40 FAS LTBR NGFR TNFRSF10A TNFRSF10B TNFRSF10D TNFRSF18 TNFRSF19 TNFRSF1A TNFRSF1B TNFRSF21 TNFRSF25 TNFRSF6B TNFRSF8 TNFRSF9
Regulators of BCL2 family Transcriptional factors:
DDIT3 JUN E2F1 CEBPE FOXO3 FOXO3 NR3C1 MYB E2F1 TP53 JUN E2F1 HIF1A MYC E2F1 HIF1A TP53 TP73 DDIT3 E2F1 FOXO3 NR3C1 TP53 TP73 TP53
Death receptors of TNF superfamily:
TNFRSF9 TNFRSF13C TNFRSF17 CD27 CD27 TNFRSF8 CD40 CD40 TNFRSF10C TNFRSF10D TNFRSF6B TNFRSF25 TNFRSF10A TNFRSF10B EDAR FAS FAS TNFRSF12A TNFRSF18 TNFRSF14 LTBR NGFR TNFRSF11B TNFRSF4 TNFRSF11A RELT TNFRSF13B TNFRSF1A TNFRSF1B TNFRSF10A TNFRSF10B TNFRSF10D TNFRSF18 TNFRSF19 TNFRSF1A TNFRSF1B TNFRSF21 TNFRSF25 TNFRSF6B TNFRSF8 TNFRSF9 TNFRSF19 EDA2R
Apoptosis factors regulated by alternative splicing:
FAS FASLG TNFRSF25 APAF1 DIABLO MADD MYD88 DIABLO BIRC5 TRAF2 TRAF3 BAX BCL2L1 BID BCL2L11 CASP10 CASP9 CFLAR ACIN1 CAD DFFA TP53 TP63 TP73
BIR Domain:
BIRC2 BIRC3 BIRC5 BIRC6 BIRC7 BIRC8 NAIP XIAP BIRC2 BIRC3 BIRC5 BIRC6 BIRC7 BIRC8 NAIP XIAP
Regulators of BCL2 family Deubiquitinylase:
USP9X
IAPs:
BIRC6 BIRC8 BIRC2 BIRC3 BIRC7 BIRC7 NAIP BIRC5 XIAP
Pro-apoptotic members:
BAK1 BAX BOK BCL2L14 BCL2L13 BOK BCL2L11 BAD BECN1 BID BIK BCL2L11 BMF HRK HRK HRK HUWE1 PMAIP1 BBC3
Regulators of BCL2 family Proteases:
CASP2 CASP8 GZMB RHBDD1
Other Regulators of Apoptosis:
BCL6 CEBPG DBP DDIT3 GRM4 LGALS1 MADD MAPK8 NKX3-2 POU4F1 PROP1 RARG STAT5A STAT5B TBK1 TDGF1 TRAF6 ZAK
Regulators of BCL2 family Phosphatases:
PPA1 PPP2CA PPP2R4 PPP2CA PPP2R4 PPP2CA PPP2R4

List of LncRNAs

The LncRNAs collected for mouse apoptosis pathway are listed in Table 1. Click an LncRNA accession number to see its detailed information and its potential target gene(s) in the apoptosis pathway.

Table 1. Mouse apoptosis pathway focused LncRNAs

ENSMUST00000092369, ENSMUST00000105060, ENSMUST00000117437, ENSMUST00000117905, ENSMUST00000118323, ENSMUST00000118796, ENSMUST00000119116, ENSMUST00000119162, ENSMUST00000119460, ENSMUST00000121061, ENSMUST00000122204, ENSMUST00000124166, ENSMUST00000124308, ENSMUST00000124663, ENSMUST00000125440, ENSMUST00000125917, ENSMUST00000126158, ENSMUST00000126970, ENSMUST00000127059, ENSMUST00000127079, ENSMUST00000131344, ENSMUST00000131456, ENSMUST00000134292, ENSMUST00000135110, ENSMUST00000135388, ENSMUST00000136437, ENSMUST00000137394, ENSMUST00000140071, ENSMUST00000140955, ENSMUST00000141115, ENSMUST00000141229, ENSMUST00000141645, 

Gene List

The potential gene targets of mouse apoptosis pathway focus LncRNAs are listed in Table 2. Click the protein gene names to see the detailed information about the genes and their corresponding regulatory LncRNAs in the apoptosis pathway.

Table 2. Functional gene grouping

Caspases:
Casp2 Casp8 Casp9 Casp3 Casp6 Casp7
Adaptor proteins of Apoptosome:
Apaf1
BCL2 and BAG Domain:
Bag1 Bag3 Bag4 Bax Bcl2 Bcl2a1a Bcl2a1b Bcl2a1d Bcl2l1 Bcl2l10 Bcl2l13 Bcl2l2 Mcl1
IAP antagonists:
Diablo Hibadh Gspt1 Csf2 Gspt1 Il5 Htra2 Diablo Diablo Xaf1
Apoptosis-related Phosphorylation/Dephosphorylation:
Akt1 Abl1 Camk2a Cdk1 Csnk2a1 Prkdc Dyrk1a Mapk3 Mapk1 Fyn Lyn Mapk1 Mapk10 Mapk11 Mapk12 Mapk13 Mapk14 Mapk3 Mapk7 Mapk8 Mapk9 Mapk14 Prkaca Prkacb Prkcd Ppa1 Ppp1ca Ppp2ca Ppp2r4 Ptpn6 Src Akt1 Atm Csnk2a1 Cdk1 Mapk3 Mapk1 Gsk3b Mapk8 Mapk14 Rps6kb1 Rps6ka1 Pak1 Pim1 Prkaca Prkacb Prkcz Ppp2ca Ppp2r4 Rps6ka1 Rps6ka3
Regulators of BCL2 family Transcriptional repressors:
Kcnip3 Trp63 Snai2 Trp63 Trp73
Adaptor proteins of death-inducing signalling complex (DISC) :
Cflar Fadd Ripk1 Tradd
Caspases & Regulators:
Casp1 Casp14 Casp2 Casp3 Casp4 Casp6 Casp7 Casp8 Casp9 Cflar Cradd Malt1 Pycard Rfwd2 Aifm3 Apaf1 Bax Bcl2l10 Bcl2l13 Casp1 Casp8ap2 Casp9 Col4a3 Diablo Eif2ak3 F2 F2r Foxl2 Hip1 Hspe1 Ifnb1 Ift57 Lck Map3k5 Moap1 Mtch1 Myc Nlrc4 Nlrp1a Nlrp1b Nlrp12 Nlrp2 Nlrp3 Nod1 Pycard Stat1 Tnfrsf10b Tnfsf15 Trp53 Tpd52l1 Vcp Birc5 Cd27 Dhcr24 Sfn Tnfaip8 Tnfsf14 Triap1 Xiap
Regulators of BCL2 family Kinases:
Akt1 Cdk1 Mapk8 Rps6kb1 Rps6ka1 Pak1 Pim1 Prkaca Prkacb Atm Csnk2a1 Mapk8 Mapk3 Mapk1 Mapk8 Rps6ka1 Rps6ka3 Csnk2a1 Mapk3 Mapk1 Mapk8 Mapk8 Mapk3 Mapk1 Gsk3b Mapk8 Akt1 Mapk3 Mapk1 Gsk3b Mapk8 Mapk14 Prkcz Ppp2ca Ppp2r4
Death ligands of TNF superfamily:
Tnfrsf9 Tnfsf13 Cd70 Tnfsf8 Cd40lg Eda Eda Eda Fasl Fasl Tnfsf18 Tnfsf14 Lta Ltb Tnfsf4 Tnfsf11 Tnfsf13b Tnf Tnfsf10 Tnfsf14 Tnfsf15 Tnfsf8 Tnfsf10 Tnfsf12
Apoptosis-related Ubiquitin and Deubiquitin:
Birc2 Birc3 Fbxw7 Itch Mdm2 Huwe1 Siah1a Siah2 Vhl Xiap Btrc Casp3 Casp7 Birc2 Birc3 Cflar Hif1a Hipk2 Nfkbia Jun Mcl1 Myc Map3k14 Trp53 Trp63 Egln2 Egln3 Ralbp1 Ripk1 Uqcrfs1 Diablo Traf2 Xiap Tnfaip3 Cyld Usp14 Usp7 Usp9x Bcl3 Casp8 Foxo4 Malt1 Mdm2 Mdm4 Ikbkg Trp53 Pten Ralbp1 Ripk1 Uqcrfs1 Ripk2 Tgfb1 Tgfb2 Tgfb3 Traf2 Traf6 Ube2d1 Ctnnb1
Anti-apoptotic members:
Bcl2 Bcl2a1a Bcl2a1b Bcl2a1d Bcl2l1 Bcl2l2 Mcl1 Bcl2l10
TNF Domain:
Eda Fasl Lta Ltb Tnf Tnfsf10 Tnfsf14 Tnfsf15 Tnfsf8
Regulators of BCL2 family Ubiquitinylase:
Btrc Huwe1 Btrc
Kinases/Phosphatases targeted by Caspases:
Akt1 Alk Bmx Abl1 Camk4 Camkk2 Egfr Erbb2 Epha3 Ptk2 Fyn Erbb2 Hipk2 Map4k1 Chuk Mapk8 Lyn Map3k1 Met Mst1 Stk4 Stk3 Stk24 2610018G03Rik Rps6kb1 Pak2 Pdgfrb Phka2 Pip5k1a Prkcd Prkce Prkcz Prkch Prkcq Pkn1 Pkn2 Eif2ak2 Pkn1 Pkn2 Raf1 Ret Ralbp1 Ripk1 Uqcrfs1 Ripk3 Rock1 Slk Src Srpk1 Srpk2 Atm Bub1 Bub1b Chek1 Ccne1 Prkdc Cdk11b Wee1 Cdc25a Ppp2ca Ppp2r4 Pten Ptpn12
Induction of Apoptosis:
Bid Cradd Daxx Dedd2 Fadd Il18 Tnf Abl1 Aifm1 Bcl3 Brca1 Chek2 Cidea Cideb Dyrk2 Mbd4 Msh6 Pcbp4 Pml Sfn Trp53 Trp73 Gpx1 Prodh Rnf7 Adora1 Btk Casp8ap2 Cd28 Cd38 Cd5 Cflar Dap Dap3 Dapk1 Dpf2 Fastk Map3k5 Ndufa13 Pdcd6 Prkca Ripk3 Spn Timp3 Tnfrsf25 Cdkn1a Cul1 Cul2 Cul3 Cul4a Cul5 Hipk2 Myc Sart1 Acvr1b Aifm2 Aifm3 Alox8 Apoe Bad Bak1 Bax Bcl10 Bcl2l11 Bcl2l13 Bclaf1 Bik Bnip1 Bnip3 Bnip3l Bok Casp3 Casp4 Casp6 Cd2 Cd27 Cd70 Cebpb Cidec Col4a3 Dapk2 Dapk3 Dcc Ddx20 Dedd Diablo Ei24 Ercc2 Ercc3 Ern1 Ern2 Fas Fasl Fem1b Foxl2 Foxo3 Hrk Htatip2 Ifnb1 Ifng Ikbip Ikbkg Il19 Inha Inhba Jmy Lalba Lck Lta Mal Map3k10 Mapk1 Ndufs3 Ngfr Nlrp1a Nlrp1b Nlrp3 Nme3 Notch2 Nudt2 Nupr1 Pdcd5 Plagl1 Plagl2 Plekhf1 Plg Ppp1r13b Ppp2ca Ppp2r1a Ppp2r1b Prkce Prkra Prune2 Pten Pth Pycard Runx3 S100b Sap30bp Serinc3 Sipa1 Smndc1 Sst Sstr3 Stk17b Tbx5 Tia1 Tial1 Tlr2 Tnfrsf10b Tnfrsf19 Tnfrsf9 Tnfsf10 Tnfsf14 Tnfsf8 Trp53bp2 Trp63 Tpd52l1 Tradd Traf3 Traip Unc13b Utp11l
TRAF Domain:
Traf2 Traf3 Traf5 Traf7 Traf2 Traf3 Traf5 Traf7
Apoptosis factors regulated by miRNAs:
Fasl Faf1 Bak1 Bax Bcl2 Bcl2l2 Bcl2l1 Bcl2l11 Mcl1 Casp9 Cflar Cdkn1a Ptpn13 Pik3r1 Pten Cdkn1a Cdkn1b Api5 Cdc42 E2f1 Sirt1
Anti-Apoptosis:
Bcl2l1 Bre Cd28 Erc1 Mapk8ip2 Opa1 Prkaa1 Rasa1 Pik3r2 Rtn4 Tnfaip8 Aatf Akt1 Alox12 Anxa1 Anxa4 Api5 Atf5 Aven Bag1 Bag3 Bag4 Bcl2 Bcl2a1a Bcl2a1b Bcl2a1d Bcl2l1 Bcl2l10 Bcl2l2 Bdnf Becn1 Bfar Birc2 Birc3 Birc5 Birc6 Birc7 Bnip1 Bnip2 Bnip3 Braf Casp2 Cbx4 Ccl12 Cd27 Cd40lg Cebpb Cfdp1 Cfl1 Cflar Cryaa Cryab Dad1 Ddah2 Dhcr24 Eef1a2 Faim Faim2 Fas Foxo1 Gdnf Gfral Glo1 Gstp1 Gstp2 Hdac1 Hdac3 Hipk3 Hmgb1 Hsp90b1 Hspa1a Hspa1b Hspa9 Hspb1 Htatip2 Htt Ier3 Igf1r Il10 Il1a Il2 Il31ra Malt1 Mcl1 Mkl1 Mpo Mtl5 Mybl2 Myo18a Naip1 Naip5 Naip6 Nfkb1 Nme5 Nol3 Notch2 Npm1 Nrg2 Ntf3 Pak7 Pax7 Pea15a Pik3ca Pim2 Pogk Polb Prdx2 Prkcz Prlr Prok2 Psen1 Rela Rnf7 Sema4d Serpinb2 Serpinb9 Sfrp1 Sh3glb1 Snca Socs2 Socs3 Son Sphk1 Spp1 Stambp Tax1bp1 Tbx3 Tgfb1 Tmx1 Tnf Tnfaip3 Tnfaip8 Tnfrsf18 Tnfsf18 Tpt1 Triap1 Tsc22d3 Vegfa Vhl Xiap Ywhaz Zc3hc1
CARD Domain:
Apaf1 Bcl10 Birc2 Birc3 Card10 Card11 Card14 Card6 Card9 Casp1 Casp2 Casp4 Casp9 Cradd Nlrp1a Nlrp1b Nod1 Nod2 Nol3 Pycard Rfwd2 Ripk2 Apaf1 Bcl10 Birc2 Birc3 Card10 Card11 Card14 Card6 Card9 Casp1 Casp2 Casp4 Casp9 Cradd Nlrp1a Nlrp1b Nod1 Nod2 Nol3 Pycard Rfwd2 Ripk2
DEATH Domain:
Cradd Dapk1 Edar Fadd Malt1 Nfkb1 Nfkb2 Ngfr Lrdd Ripk1 Tnfrsf10b Tnfrsf1a Tnfrsf21 Tnfrsf25 Tradd Cradd Dapk1 Edar Fadd Malt1 Nfkb1 Nfkb2 Ngfr Lrdd Ripk1 Tnfrsf10b Tnfrsf1a Tnfrsf21 Tnfrsf25 Tradd
TNFR Domain:
Cd27 Cd40 Fas Ltbr Ngfr Tnfrsf10b Tnfrsf18 Tnfrsf19 Tnfrsf1a Tnfrsf1b Tnfrsf21 Tnfrsf25 Tnfrsf8 Tnfrsf9
Regulators of BCL2 family Transcriptional factors:
Ddit3 Jun E2f1 Cebpe Foxo3 Foxo3 Nr3c1 Myb E2f1 Trp53 Jun E2f1 Hif1a Myc E2f1 Hif1a Trp53 Trp73 Ddit3 E2f1 Foxo3 Nr3c1 Trp53 Trp73 Trp53
Death receptors of TNF superfamily:
Tnfrsf9 Tnfrsf13c Tnfrsf17 Cd27 Cd27 Tnfrsf8 Cd40 Cd40 Tnfrsf25 Tnfrsf10b Edar Fas Fas Tnfrsf12a Tnfrsf18 Tnfrsf14 Ltbr Ngfr Tnfrsf11b Tnfrsf4 Tnfrsf11a Relt Tnfrsf13b Tnfrsf1a Tnfrsf1b Tnfrsf10b Tnfrsf18 Tnfrsf19 Tnfrsf1a Tnfrsf1b Tnfrsf21 Tnfrsf25 Tnfrsf8 Tnfrsf9 Tnfrsf19 Eda2r
Apoptosis factors regulated by alternative splicing:
Fas Fasl Tnfrsf25 Apaf1 Diablo Madd Myd88 Diablo Birc5 Traf2 Traf3 Bax Bcl2l1 Bid Bcl2l11 Casp9 Cflar Acin1 Cad Dffa Trp53 Trp63 Trp73
BIR Domain:
Birc2 Birc3 Birc5 Birc6 Birc7 Naip1 Naip5 Naip6 Xiap Birc2 Birc3 Birc5 Birc6 Birc7 Naip1 Naip5 Naip6 Xiap
Regulators of BCL2 family Deubiquitinylase:
Usp9x
IAPs:
Birc6 Birc2 Birc3 Birc7 Birc7 Naip1 Naip5 Naip6 Birc5 Xiap
Pro-apoptotic members:
Bak1 Bax Bok Bcl2l14 Bcl2l13 Bok Bcl2l11 Bad Becn1 Bid Bik Bcl2l11 Bmf Hrk Hrk Hrk Huwe1
Regulators of BCL2 family Proteases:
Casp2 Casp8 Gzmb Rhbdd1
Other Regulators of Apoptosis:
Bcl6 Cebpg Dbp Ddit3 Grm4 Lgals1 Madd Mapk8 Nkx3-2 Pou4f1 Prop1 Rarg Stat5a Stat5b Tbk1 Tdgf1 Traf6
Regulators of BCL2 family Phosphatases:
Ppa1 Ppp2ca Ppp2r4 Ppp2ca Ppp2r4 Ppp2ca Ppp2r4