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Product NameCatalog NoDescriptionFormatPrice
LncPath™ Human Angiogenesis Pathway Microarray AS-LP-012H 828 LncRNAs and 251 their potential coding targets 8*15K
LncPath™ Mouse Angiogenesis Pathway Microarray AS-LP-012M 339 LncRNAs and 448 their potential coding targets 8*15K

Angiogenesis is a vital process of new blood vessel formation.  It is a highly regulated process that occurs during normal human development, reproduction, and wound healing.  An angiogenic imbalance contributes to numerous malignant, inflammatory, ischemic, infectious and immune disorders [1,2]. The molecular mechanisms behind angiogenesis are not fully understood. Recent research has suggested the essential roles of LncRNAs in the regulation of angiogenesis.

The LncPath™ Human Angiogenesis Pathway LncRNA Microarray simultaneously profiles the expression of 828 LncRNAs and 251 their potential coding targets related to the angiogenesis signaling pathway. The LncPath™ Mouse Angiogenesis Pathway LncRNA Microarray simultaneously profiles the expression of 339 LncRNAs and 448 their potential coding targets related to the angiogenesis signaling pathway. The LncRNAs whose genes are located at or near the protein-coding genes critical in the angiogenesis pathway, and the LncRNAs that have high possibilities of being competing endogenous RNAs (ceRNAs) of the key angiogenesis genes, are carefully collected from authoritative databases using rigorous selection processes. By focusing on the LncRNAs most relevant to the angiogenesis pathway, the array can achieve much faster and more precise analysis, due to the highly specific yet smaller amount of data to analyze. More importantly, it can establish the expressional relationships between the LncRNAs and their protein-coding gene targets involved in the angiogenesis signaling pathway, thereby providing comprehensive insights into the underlying regulatory mechanisms of LncRNAs in angiogenesis.

Comprehensive and reliable collection of angiogenesis pathway focused LncRNAs.

Simultaneous analysis of LncRNAs and their protein-coding gene targets in the angiogenesis pathway.

Explore and establish expressional relationships and regulatory mechanisms between the LncRNAs and the target pathway genes.

Faster and more precise pathway-focused analysis.

Efficient and robust labeling system.

Innovative probe design.

Guaranteed performance.

An example showing the detailed information about the LncRNAs and their potential coding gene target

Click the LncRNA accession number listed in databases, you will see the figures showing the detailed information about the LncRNAs and their potential target gene.

ADAM15

Figure 1. The genomic map views of the LncRNA NR-040772 and its potential target gene ADAM15. From the top to the bottom of the figure 1, the following items are displayed:

Genome view: A chromosome ideogram showing the map position of the LncRNA NR-040772 and its potential target gene ADAM15(red bar).

Map view ruler: The map coordinates of the human genome assembly hg19 for the map views below.

LncRNA map view: The LncRNAs whose genes located at or near the ADAM15 gene are presented in the Noncoding panel (shaded green). The LncRNAs are indicated by the transcript IDs, the exons by solid blocks, the introns by thin lines, and the transcription directions by arrows. The exons of LncRNA NR-040772 are labeled in red, while the exons of the other LncRNAs are labeled in blue.

Coding gene map view: The coding gene ADAM15 is presented in the Coding panel (shaded blue). The coding gene is indicated by its canonical transcript ID, the exons by solid blocks, the introns by thin lines, and the transcription direction by arrows.

ADAM15-1

Figure 2. The relationship between LncRNA NR-040772 and its protein coding gene target ADAM15. The other neighboring LncRNAs which may regulate ADAM15 expression are also shown.

ADAM15-2

Figure 3. The LncRNA ENST00000518798 may function as a competing endogenous RNA (ceRNA) of the protein coding gene ADAM15.

* MuTaMe Score, Mutually Targeted MRE Enrichment Score [3].

References
1. Nussenbaum, F. and I. M. Herman (2010) J Oncol 2010: 132641.
2. Carmeliet, P. (2005) Nature 438 (, 7070): 932-6.
3. Tay, Y., et al. (2011) Cell 147 (2): 344-57.

List of LncRNAs

The LncRNAs collected for human angiogenesis pathway are listed in Table 1. Click an LncRNA accession number to see its detailed information and its potential target gene(s) in the angiogenesis pathway.

Table 1. Human angiogenesis pathway focused LncRNAs

ENST00000279573, ENST00000331871, ENST00000339626, ENST00000357401, ENST00000359823, ENST00000371455, ENST00000374207, ENST00000380759, ENST00000392696, ENST00000408043, ENST00000411661, ENST00000413053, ENST00000413334, ENST00000413968, ENST00000414314, ENST00000415589, ENST00000419531, ENST00000419644, ENST00000420181, ENST00000421411, ENST00000421735, ENST00000421965, ENST00000422438, ENST00000422953, ENST00000423102, ENST00000423231, ENST00000423367, ENST00000423763, ENST00000424339, ENST00000425674, ENST00000426714, ENST00000426771, ENST00000427283, ENST00000428966, ENST00000429512, ENST00000430017, ENST00000430612, ENST00000430696, ENST00000433324, ENST00000433426, ENST00000434363, ENST00000434541, ENST00000435287, ENST00000435478, ENST00000435789, ENST00000436315, ENST00000436963, ENST00000437673, ENST00000437689, ENST00000438325, ENST00000439598, ENST00000441575, ENST00000443800, ENST00000443919, ENST00000444188, ENST00000444223, ENST00000444359, ENST00000444577, ENST00000446355, ENST00000446383, ENST00000447119, ENST00000447702, ENST00000448126, ENST00000449737, ENST00000451485, ENST00000452009, ENST00000452246, ENST00000452520, ENST00000454260, ENST00000454712, ENST00000459877, ENST00000461864, ENST00000462029, ENST00000462431, ENST00000464067

Full List of Human Angiogenesis Pathway Focused LncRNAs.pdf

 

Gene List

The potential gene targets of human angiogenesis pathway focus LncRNAs are listed in Table 2. Click the protein gene names to see the detailed information about the genes and their corresponding regulatory LncRNAs in the angiogenesis pathway.

Table 2. Functional gene grouping

 
Growth factors and receptors:
ANGPT1 ANGPT2 ANGPT1 ANGPT4 CTGF EDIL3 TYMP EGF CXCL5 EFNB2 EREG FGF1 FGF13 FGF2 FGF4 FGF5 FGFBP1 FIGF CXCL6 CSF3 GRN GRP HGF IL8 KITLG LEP MDK NTN1 PEBP1 TYMP PDGFB PDGFB PDGFD PGF PIGF PIGF PIGF PROK1 SEMA3B SEMA3E SEMA3F SEMA4D SLIT2 TGFA TGFB1 TGFB2 TGFB3 TNF VEGFA VEGFB VEGFC FIGF ALK DCC EGFR EPHB2 EPHB4 FAS FGFR1 FGFR2 FGFR3 FGFR4 GRPR LEPR LRP1 MET NPTX1 NPTX2 PDGFRA PDGFRB PLXNB2 PROKR1 ROBO4 MST1R TGFBR1 TGFBR2 UNC5B FLT1 KDR FLT4
Adhesion molecules:
CDH13 CLDN3 CLDN4 CLDN5 CDH1 ESAM SELE ICAM1 ICAM2 F11R JAM2 JAM3 CDH12 CDH2 NRCAM OCLN SELP VCAM1 CDH5
Chemoattractants and receptors:
ANGPT2 FGF2 PROK2 CCL11 CCL2 CCL3 CCL4 CCL8 CXCL1 CXCL12 CXCL3 CXCL5 CXCL6 IL8 EGF HGF IL3 KIAA0101 FIGF PDGFA PDGFB PDGFC PDGFD VEGFB VEGFC PIGF KITLG TGFB1 VEGFA CCR1 CCR2 CCR3 CCR5 CCR6 CXCR1 CXCR2 CXCR4 KIT TEK FLT1 KDR
PDGF pathway in angiogenesis:
EPHB2 PDGFA PDGFB PDGFC PDGFD PDGFRA PDGFRB PIK3CA RAF1
FGF pathway in angiogenesis:
MAPK3 MAPK1 FGF1 FGF13 FGF2 FGF4 FGF5 FGFR1 FGFR2 FGFR3 FGFR4 MAPK8 MAP2K1 MAP3K1 PIK3CA RAF1 HRAS KRAS NRAS
VEGF pathway in angiogenesis:
AKT1 FOS PLA2G4A DAG1 NOS3 MAPK3 MAPK1 GRB2 JAK2 MAP2K1 MAP2K2 PIK3CA PIGF PIGF AKT1 RAF1 HRAS KRAS NRAS SHC1 STAT5A VEGFA VEGFB VEGFC FLT1 KDR FLT4
Angiogenesis Inhibitors and Related Genes:
CXCL10 CXCL11 CXCL2 PF4 CXCL9 IFNA1 IFNB1 IFNG IL12A IL12B IL17F CXCL10 CXCL9 PF4 TGFB1 CXCR3 HSPG2 IL12RB1 IL12RB2 PRL TIE1 ADAMTS1 ANGPT2 ANGPTL1 BAI1 CD55 CD59 CHGA COL15A1 COL18A1 COL4A1 COL4A2 COL4A3 F2 FBLN5 FGA ITGA4 KLK3 LECT1 FOXO4 NPPB NPR1 PLG PRL RNH1 SEMA3F SERPINB5 SERPINC1 SERPINE1 SERPINF1 SPINK5 STAB1 THBS1 THBS2 TIMP1 TIMP2 TIMP3 TNFSF15 TNMD TNNI1 TNNI2 TNNI3 VASH1
Endogenous regulators of angiogenesis:
FGF1 FGF2 ANG HGF PGF TGFA TGFB1 TNF VEGFA PLAU SERPINE1 JUN MYC SRC HRAS KRAS NRAS TP53 RB1 ANGPT1 NOS1 ANGPT2 CAV1 CAV2
Ang pathway in angiogenesis:
TNIP2 AKT1 ANGPT1 ANGPT2 ANGPTL1 ANGPT4 ANGPT1 ANGPT2 BAD CASP9 DOK2 NOS3 MAPK3 MAPK1 PTK2 FOXO1 GRB14 GRB2 GRB7 CHUK IKBKB IKBKG MAP2K1 NCK1 SART3 PIK3R1 PAK1 PIK3CA RAF1 HRAS KRAS NRAS RASA1 PTPN11 STAT1 STAT3 STAT5A BIRC5 TIE1 TEK
Proteases:
MMP1 MMP10 MMP12 MMP13 MMP19 MMP2 MMP26 MMP3 MMP7 MMP8 MMP9 MMP14 MMP15 MMP16 MMP17 ADAM10 ADAM12 ADAM15 ADAM17 ADAM19 ADAM8 ADAM9 ADAMTS1 ADAMTS4 ADAMTS5 SERPINE1 SERPINB2 PLAT PLAU PLAUR RECK TIMP1 TIMP2 TIMP3 TIMP4

 

List of LncRNAs

The LncRNAs collected for mouse angiogenesis pathway are listed in Table 1. Click an LncRNA accession number to see its detailed information and its potential target gene(s) in the angiogenesis pathway.

Table 1. Mouse angiogenesis pathway focused LncRNAs

ENSMUST00000092369, ENSMUST00000099974, ENSMUST00000105060, ENSMUST00000117834, ENSMUST00000117905, ENSMUST00000121413, ENSMUST00000122179, ENSMUST00000123449, ENSMUST00000124166, ENSMUST00000124508, ENSMUST00000124577, ENSMUST00000125440, ENSMUST00000125917, ENSMUST00000125962, ENSMUST00000126850, ENSMUST00000126983, ENSMUST00000127079, ENSMUST00000127456, ENSMUST00000128182, ENSMUST00000128654, ENSMUST00000128904, ENSMUST00000130520, ENSMUST00000132117, ENSMUST00000134324, ENSMUST00000135110, ENSMUST00000136630, ENSMUST00000137394, ENSMUST00000138764, ENSMUST00000139612, ENSMUST00000141076, ENSMUST00000142642, ENSMUST00000143224, ENSMUST00000144765, ENSMUST00000145411, ENSMUST00000146690, ENSMUST00000148268, ENSMUST00000149252, ENSMUST00000150734, ENSMUST00000153740, ENSMUST00000153862, 

Full List of Mouse Angiogenesis Pathway Focused LncRNAs.pdf

 

Gene List 

The potential gene targets of mouse angiogenesis pathway focus LncRNAs are listed in Table 2. Click the protein gene names to see the detailed information about the genes and their corresponding regulatory LncRNAs in the angiogenesis pathway.

Table 2. Functional gene grouping

Growth factors and receptors:
Angpt1 Angpt2 Angpt1 Angpt4 Ctgf Edil3 Tymp Egf Efnb2 Ereg Fgf1 Fgf13 Fgf2 Fgf4 Fgf5 Fgfbp1 Figf Cxcl5 Csf3 Grn Grp Hgf Kitl Lep Mdk Ntn1 Pebp1 Tymp Pdgfb Pdgfb Pdgfd Pgf Pigf Pigf Pigf Prok1 Sema3b Sema3e Sema3f Sema4d Slit2 Tgfa Tgfb1 Tgfb2 Tgfb3 Tnf Vegfa Vegfc Figf Alk Dcc Egfr Ephb2 Ephb4 Fas Fgfr1 Fgfr2 Fgfr3 Fgfr4 Grpr Lepr Lrp1 Met Nptx1 Nptx2 Pdgfra Pdgfrb Plxnb2 Prokr1 Robo4 Mst1r Tgfbr1 Tgfbr2 Unc5b Flt1 Kdr Flt4
Adhesion molecules:
Cdh13 Cldn3 Cldn4 Cldn5 Cdh1 Esam Sele Icam1 Icam2 F11r Jam2 Jam3 Cdh12 Cdh2 Nrcam Ocln Selp Vcam1 Cdh5
Chemoattractants and receptors:
Angpt2 Fgf2 Prok2 Ccl11 Ccl12 Ccl4 Cxcl3 Cxcl2 Cxcl5 Egf Hgf 2810417H13Rik Figf Pdgfa Pdgfb Pdgfc Pdgfd Vegfc Pigf Kitl Tgfb1 Vegfa Ccr1 Ccr2 Ccr3 Ccr5 Ccr6 Cxcr1 Cxcr2 Cxcr4 Kit Tek Flt1 Kdr
PDGF pathway in angiogenesis:
Ephb2 Pdgfa Pdgfb Pdgfc Pdgfd Pdgfra Pdgfrb Pik3ca Raf1
FGF pathway in angiogenesis:
Mapk3 Mapk1 Fgf1 Fgf13 Fgf2 Fgf4 Fgf5 Fgfr1 Fgfr2 Fgfr3 Fgfr4 Mapk8 Map2k1 Map3k1 Pik3ca Raf1 Hras1 Kras Nras
VEGF pathway in angiogenesis:
Akt1 Fos Pla2g4a Dag1 Nos3 Mapk3 Mapk1 Grb2 Jak2 Map2k1 Map2k2 Pik3ca Pigf Pigf Akt1 Raf1 Hras1 Kras Nras Shc1 Stat5a Vegfa Vegfc Flt1 Kdr Flt4
Angiogenesis Inhibitors and Related Genes:
Cxcl10 Cxcl1 Pf4 Cxcl9 Gm12597 Gm13280 Ifna1 Ifna11 Ifna12 Ifna13 Ifna14 Ifna2 Ifna5 Ifna6 Ifna7 Ifna9 Ifnab Ifnb1 Ifng Il12a Il12b Il17f Cxcl10 Cxcl9 Pf4 Tgfb1 Cxcr3 Hspg2 Il12rb1 Il12rb2 Prl Tie1 Adamts1 Angpt2 Angptl1 Bai1 Cd59b Chga Col15a1 Col18a1 Col4a1 Col4a2 Col4a3 F2 Fbln5 Fga Itga4 Klk1 Klk1b1 Klk1b11 Klk1b16 Klk1b21 Klk1b22 Klk1b24 Klk1b26 Klk1b27 Klk1b3 Klk1b4 Klk1b5 Klk1b8 Klk1b9 Lect1 Foxo4 Npr1 Plg Prl Rnh1 Sema3f Serpinb5 Serpinc1 Serpine1 Serpinf1 Spink5 Stab1 Thbs1 Thbs2 Timp1 Timp2 Timp3 Tnfsf15 Tnmd Tnni1 Tnni2 Tnni3 Vash1
Endogenous regulators of angiogenesis:
Fgf1 Fgf2 Ang Hgf Pgf Tgfa Tgfb1 Tnf Vegfa Plau Serpine1 Jun Myc Src Hras1 Kras Nras Trp53 Rb1 Angpt1 Nos1 Angpt2 Cav1 Cav2
Ang pathway in angiogenesis:
Tnip2 Akt1 Angpt1 Angpt2 Angptl1 Angpt4 Angpt1 Angpt2 Bad Casp9 Dok2 Nos3 Mapk3 Mapk1 Ptk2 Foxo1 Grb14 Grb2 Grb7 Chuk Ikbkb Ikbkg Map2k1 Nck1 Sart3 Pik3r1 Pak1 Pik3ca Raf1 Hras1 Kras Nras Rasa1 Ptpn11 Stat1 Stat3 Stat5a Birc5 Tie1 Tek
Proteases:
Mmp1a Mmp10 Mmp12 Mmp13 Mmp19 Mmp2 Mmp3 Mmp7 Mmp8 Mmp9 Mmp14 Mmp15 Mmp16 Mmp17 Adam10 Adam12 Adam15 Adam17 Adam19 Adam8 Adam9 Adamts1 Adamts4 Adamts5 Serpine1 Serpinb2 Plat Plau Plaur Reck Timp1 Timp2 Timp3 Timp4